[PDF] Top 20 Genetic analysis of the attenuation phenotype of poliovirus type 1.
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Genetic analysis of the attenuation phenotype of poliovirus type 1.
... SEMLER,5t ATSUKO KAMEDA,' HEIHACHI ITOH,3§ MINEO ARITA,4 ECKARD WIMMER,s AND AKIO NOMOTO2* Department of Public Health, School of Pharmaceutical Sciences, Kitasato University, Minato-ku,[r] ... See full document
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A Host-Specific, Temperature-Sensitive Translation Defect Determines the Attenuation Phenotype of a Human Rhinovirus/Poliovirus Chimera, PV1(RIPO)
... rhinosvirus/poliovirus type 1 chimera, PV1(RIPO), with the cognate internal ribosome entry site (IRES) of human rhinovirus type 2 (HRV2), we set out to shed light on the mechanism by which ... See full document
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Characterization of CHAT and Cox Type 1 Live-Attenuated Poliovirus Vaccine Strains
... Sabin 1 and, to a limited extent, to its attenuation phenotype (3, 8, 35, 49, ...most poliovirus strains but absent in Sabin 3 and its wild parent, Leon ...virus phenotype (12, ... See full document
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Phenotype prediction for mucopolysaccharidosis type I by in silico analysis
... than 1% ...than 1% were also included in the ...silico analysis contributed to predicting the functional non-synonymous SNPs (nsSNPs) in genes such as G6PD [10], ATM [11], PTEN [12], BRAF [13] and ... See full document
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Shedding of Vaccine Viruses with Increased Antigenic and Genetic Divergence after Vaccination of Newborns with Monovalent Type 1 Oral Poliovirus Vaccine
... Sabin type 1 is considered to be the most stable of the three attenuated poliovirus serotypes ...for attenuation. Sabin type 2 has two major determinants of attenuation, and ... See full document
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Cooperative Effect of the Attenuation Determinants Derived from Poliovirus Sabin 1 Strain Is Essential for Attenuation of Enterovirus 71 in the NOD/SCID Mouse Infection Model
... the attenuation determinants de- rived from the type 1 PV vaccine strain, Sabin 1 [PV1(Sabin)], on the virulence of EV71, we developed an adult mouse infec- tion model of EV71 with ... See full document
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Role of mutations G-480 and C-6203 in the attenuation phenotype of Sabin type 1 poliovirus.
... Sabin 1 and P1/Mahoney in primates (8, 14, 18) supported the conclusion that there are multiple determinants of attenuation, in that all genomic regions recombined into a P1/Mahoney strain appar- ently ... See full document
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Inhibition of endoplasmic reticulum-to-Golgi traffic by poliovirus protein 3A: genetic and ultrastructural analysis.
... Mahoney type 1 poliovirus cDNA, using deoxyoligonucleotide primers designed to introduce a SalI site and an AUG start codon immediately upstream and a stop codon and a SmaI site immediately ... See full document
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Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain.
... Structural analysis of the amino-terminal 55 amino acids of HIV-1 (4) as well as direct evidence of zinc-binding abilities of this domain (6, 44) showed that the zinc finger-like region is a discrete domain ... See full document
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Genetic Determinants of Cell Type-Specific Poliovirus Propagation in HEK 293 Cells
... All Sabin serotypes feature point mutations within a con- fined region of IRES stem-loop domain (SLD) V (see Fig. 2 and 4) that have been implicated in the attenuation phenotype. The IRES occupies the ... See full document
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Analysis of RNA synthesis of type 1 poliovirus by using an in vitro molecular genetic approach.
... Viral replication in HeLa cells infected with PV-1S, the attenuated derivative of PV-1M isolated by Sabin 30, has long been known to be temperature sensitive 9, and this temperature sens[r] ... See full document
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Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine.
... of attenuation at amino acids 1106 and 1134, which is consistent with earlier results suggesting the presence of determinants within VP2, VP3, and VP1 ...ts phenotype is also conferred by amino acid 1088 of ... See full document
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Determinants in the 5' noncoding region of poliovirus Sabin 1 RNA that influence the attenuation phenotype.
... Monkey neurovirulence tests on the recombinant virus whose genome had a guanine residue Sabin type at position 480 and variants generated from this recombinant virus in the central nervo[r] ... See full document
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Phenotype-genotype relations in facioscapulohumeral muscular dystrophy type 1
... dystrophy type 1 (FSHD1) can be explained by the D4Z4 repeat array size, D4Z4 methylation and familial factors, we included 152 carriers of an FSHD1 allele (23 single cases, 129 familial cases from 37 ... See full document
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Identification of a T-cell epitope adjacent to neutralization antigenic site 1 of poliovirus type 1.
... Immunization of BALB/c H-2d mice with the uncoupled p86-115 peptide, which represents VP1 amino acids 86 to 115 and contains both the T-cell epitope and the C3 neutralization epitope, in[r] ... See full document
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Impaired Binding of Standard Initiation Factors Mediates Poliovirus Translation Attenuation
... oral poliovirus vaccine, three attenuated virus strains generated by Albert Sabin are ...insufficient genetic stability of these strains causes major problems in poliovirus ...plus-strand ... See full document
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Genetic analysis of the human immunodeficiency virus type 1 integrase protein.
... Unlike mutant D116A virions, however, viral particles produced by protease-defective HIV-1 28, murine leukemia virus 11, and avian leukosis virus 54 contain reverse transcriptase activit[r] ... See full document
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Isolation and preliminary characterization of temperature-sensitive mutants of poliovirus type 1.
... When the RNA species produced during infection by either wild-type virus or tsB9 at the permissive temperature were examined by agarose gel electrophoresis, no difference was seen.. At t[r] ... See full document
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Prolonged Replication of a Type 1 Vaccine Derived Poliovirus in an Immunodeficient Patient
... Selective amplification of m variant poliovirus sequences by PCR. A nested, two-step PCR assay was developed for selective amplification of m variant sequences. In the first step, nonselective primers VP1/245A and ... See full document
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Molecular Mechanisms of Attenuation of the Sabin Strain of Poliovirus Type 3
... that attenuation of Sabin3 within CNS cells is due to a decrease in the translation efficiency of Sabin3 relative to that of Leon resulting from the decreased amount of PTB within the CNS coupled to a de- crease ... See full document
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