[PDF] Top 20 Genetic Analysis of Sequences in the 3′ Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication
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Genetic Analysis of Sequences in the 3′ Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication
... variable region introduced into an infectious genome is viable in vivo ...of RNA replication and whether the full complement of the vari- able region is dispensable for RNA ... See full document
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A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication
... this region abol- ish Con1 RNA replication ...HCV RNA replication efficiency, we confirmed that I131V and an upstream substitution, V128I, did not significantly affect Con1 RNA ... See full document
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Intragenic Complementation of Hepatitis C Virus NS5A RNA Replication-Defective Alleles
... of replication-defective NS5A ...and C [Table 1]), each of which is potentially associated with a distinct RNA replication function ...N-terminal region of NS5A domain I (P29A, L31A, ... See full document
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Poly(C)-Binding Protein 2 Interacts with Sequences Required for Viral Replication in the Hepatitis C Virus (HCV) 5′ Untranslated Region and Directs HCV RNA Replication through Circularizing the Viral Genome
... untranslated region (5 ⴕ UTR) of hepatitis C virus (HCV) RNA is important for modu- lating both translation and RNA ...while RNA replication requires a ... See full document
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Genetic Analysis of the Carboxy-Terminal Region of the Hepatitis C Virus Core Protein
... infectious virus production, as individual substitutions resulted in wild-type titers and a core protein fragment comprising residues 1 to 177 efficiently complemented assembly in ...the C-terminal 14 ... See full document
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A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS5B
... served RNA secondary structures in coding regions has been analyzed extensively by reverse genetic analysis, predominantly using antibiotic resistance or a luciferase-encoding subgenomic replicon ... See full document
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Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.
... Hepatitis C virus (HCV) is now recognized as the principal agent of parenterally transmitted non-A, non-B ...positive-sense RNA, encoding a large polyprotein of about 3,010 to 3,033 amino ... See full document
9
Sequences in the 5′ Nontranslated Region of Hepatitis C Virus Required for RNA Replication
... that sequences at the 5⬘ end of a viral RNA genome are very important determinants for replication, we anticipated that the same might be true for ...The region upstream of the IRES ... See full document
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3′ Nontranslated RNA Signals Required for Replication of Hepatitis C Virus RNA
... restore replication competence (Fig. 6B). Thus, the 3⬘ 30 nt of the 85-nt polypyrimidine tract in Ntat2ANeo(SI) are insufficient to support RNA ...restore replication competence to the ... See full document
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DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication
... blot analysis of the lysates demonstrated the only trace of DDX3 protein in DDX3 knockdown O cells (DDX3i#3) ...HCV RNA in these ...HCV-O RNA was notably suppressed in DDX3 knockdown O cells ... See full document
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A Hepatitis C Virus NS5A Phosphorylation Site That Regulates RNA Replication
... the RNA replication kinetics of RNAs harboring these muta- FIG 1 Identification of serine 222 as a phosphorylation ...LC-MS-MS analysis. Peptide sequences are listed along with their ... See full document
6
Repair and Polyadenylation of a Naturally Occurring Hepatitis C Virus 3′ Nontranslated Region-Shorter Variant in Selectable Replicon Cell Lines
... linker sequences connecting the poly(A) tail and the correct 3 ⬘ end ...heterogeneous sequences link- ing the poly(A) tail and the 3 ⬘ end were reported during the terminal repair process of ... See full document
8
Kissing-Loop Interaction in the 3′ End of the Hepatitis C Virus Genome Essential for RNA Replication
... the 3 ⴕ NTR by using NMR. In the course of our genetic study of ...loop region was complementary to 7 nt in the loop of SL2 in the ...for RNA replication, is of functional ...mentary ... See full document
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3′ RNA Elements in Hepatitis C Virus Replication: Kissing Partners and Long Poly(U)
... increased replication fitness, the 16-U and 7-U sequences were cloned into the nonreporter J6/JFH genome and maintained in culture for up to 14 ...detectable replication of the 16-U or 7-U sequence ... See full document
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Role of the 5′-Proximal Stem-Loop Structure of the 5′ Untranslated Region in Replication and Translation of Hepatitis C Virus RNA
... and 3 ⴕ ends (5 ⴕ UTR and 3 ⴕ UTR) of the hepatitis C virus (HCV) RNA genome are highly conserved and contain cis-acting RNA elements for HCV RNA ...distinct ... See full document
7
Mutational Analysis of the Hypervariable Region of Hepatitis E Virus Reveals Its Involvement in the Efficiency of Viral RNA Replication
... chimeric hepatitis E viruses with swapped HVRs are replication competent in ...HVR sequences between HEV ...chimeric hepatitis E viruses with swapped HVRs (pSKHEV2-Sw, pSHEV3-Hu, and ... See full document
10
The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly
... this region of the polyprotein, per- haps stabilizing the protein fold or a protein-protein interac- ...genome replication by inducing membrane rear- rangements and may form a scaffold for replicase ... See full document
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Enhancement of Hepatitis C Virus RNA Replication by Cell Culture-Adaptive Mutations
... replicon RNA was ...total RNA was isolated from a cell line that harbored an NS3-5B replicon (cell line 5-15 [30]) and transfected into naı¨ve Huh-7 ...total RNA was prepared and transfected into ... See full document
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Use of Sequence Analysis of the NS5B Region for Routine Genotyping of Hepatitis C Virus with Reference to C/E1 and 5′ Untranslated Region Sequences
... 4 C/E1 is presented in ...age genetic distance observed in C/E1 between isolates of subtype 4q and of this cluster fell short compared to that observed between 4a and 4c sequences ...The ... See full document
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Viral RNA Mutations Are Region Specific and Increased by Ribavirin in a Full-Length Hepatitis C Virus Replication System
... the RNA replicase, local nucleotide signals, and two major constraints: first, con- straints on viral proteins related to both structure and function, and second, constraints on the RNA sequence ...and ... See full document
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