[PDF] Top 20 Genetic association tests: a method for the joint analysis of family and case-control data
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Genetic association tests: a method for the joint analysis of family and case-control data
... genomic control methods. Further, we have shown the power of this method for binary traits in various types of family, population-based and combined samples at a con- stant type I error rate and, ... See full document
19
Logistic Bayesian LASSO for detecting association combining family and case control data
... the data set, only 17 contain complete case–parent trios (ie, genotype information for both parents and the child and phenotype status for the child are all available), leading to a total of only 25 such ... See full document
5
A comparative analysis of family based and population based association tests using whole genome sequence data
... rare-variant tests. FBAT-v is analogous to gene-based burden tests developed for case-control stu- ...random genetic component is intro- duced and tested. It allows genetic ... See full document
5
A combined association test for rare variants using family and case control data
... sequence data for the CEU (Utah residents with Northern and Western European ancestry) and MXL (Mexican ancestry in Los Angeles, California) populations, where each set consists of 10,000 ...and ... See full document
5
Genome wide association tests by using block information in family data
... SNP data of chromosome 6 of the GAW15 Problem 3 simulated rheumatoid arthritis (RA) ...The data con- tains 100 replications ...this analysis, we used only family ...the data provided, ... See full document
5
Evaluation of association tests for rare variants using simulated data sets in the Genetic Analysis Workshop 17 data
... four association tests for rare variants — the combined multivariate and collapsing (CMC) method, two weighted-sum methods, and a variable threshold method — by applying them to the simulated ... See full document
5
A Framework for Protein-Level Interpretation of Genetic Associations and Integration With Large-Scale DNA Sequencing Analysis
... Gene-based association was performed using three distinct, but related, analytical ...first analysis, a burden test was applied to all rare (MAF<1%) protein truncating (PT) variants since the functional ... See full document
181
Joint analysis of case parents trio and unrelated case control designs in large scale association studies
... new method for testing association when data from both case-parents trios and unrelated controls are ...a joint analysis. In a two-stage analysis for testing a large ... See full document
5
A general method for combining different family based rare variant tests of association to improve power and robustness of a wide range of genetic architectures
... of family-based rare-variant tests of ...rare-variant tests on pedigree data that condition on genotype ...posed method does not limit the researcher to combin- ing just 1 ... See full document
6
Comparing the power of family based association tests for sequence data with applications in the GAW18 simulated data
... using family-based controls is the ability to identify and correct technological artifacts in the data, investigations of questions such as parent-of-origin effects and other applications that are ... See full document
7
Accounting for relatedness in family based association studies: application to Genetic Analysis Workshop 18 data
... Balding-Nichols method [4]; (b) FaST-LMM [5], which also implements 2 methods to adjust for related- ness: one using a standard covariance matrix and one using the realized relationship matrix; (c) the polygenic/ ... See full document
5
Association analysis of whole genome sequencing data accounting for longitudinal and family designs
... the association between common SNPs and SBP. All 6 tests produced proper type I error because their genomic control parameter λ s are close to ...the data are well described by our models and ... See full document
7
An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies
... the analysis of secondary phenotype data collected in a case-control study, Lin and Zeng have proposed a method that properly reflects the case-control sampling (Lin and ... See full document
5
Evaluation of gene based association tests for analyzing rare variants using Genetic Analysis Workshop 18 data
... rich data for the analysis of the role of rare variants in complex human diseases and ...pooled association tests have been proposed for joint analysis of a group of rare ...of ... See full document
6
Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case control association study
... Perhaps surprisingly, our study did not validate some previously described findings, even though it had enough power to detect the effect sizes reported by those studies (Additional file 2). Some of those associations ... See full document
9
Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families
... for association analysis of dichotomous phenotypes with family-based samples [17, ...the genetic association with family-based samples is tested by building a genotype ... See full document
13
Comparison of multiple single nucleotide variant association tests in a meta analysis of Genetic Analysis Workshop 19 family and unrelated data
... among genetic variants. We use a weighted least- squares method [9] to meta-analyze the beta coefficients for the K′ haplotypes observed in one or more ... See full document
5
Family based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families
... the family-based ap- proach which was taken in this ...genome-wide association studies (GWAS) instead of family-based methods where sample sizes are more ...statistical genetic methods is ... See full document
10
Case control association testing by graphical modeling for the Genetic Analysis Workshop 17 mini exome sequence data
... Over the first 50 simulated data sets, our graphical mod- eling method identified, on average, 1.4 SNPs in causal genes per data set. Of these correctly identified SNPs, 90.2% were exactly the causal ... See full document
5
Linkage, case control association, and family based association tests for complex disorders
... this method is appro- priate for many data sets, when dense markers are spaced uniformly across a chromosome, it is unclear how to define clusters and an alternative approach must be ... See full document
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