[PDF] Top 20 Genome wide association study meta analysis identifies five new loci for systemic lupus erythematosus

... pathway-based analysis we have identified four biological pathways associated with ...identify new genetic risk vari- ation for SLE, our approach excluded all association signals from previously ... See full document

... SDH Study Group 35 , Q-MEGA and QTWIN Investigators 35 , AMFS Investigators 35 , ATHENS Melanoma Study Group 35 ,Maria Teresa Landi 23 , Julie Lang 36 , ... See full document

... gene Association Resource (CARe) Project 23,54 , which genotyped African Americans in ARIC, MESA, CHS, CARDIA, the Jackson Heart Study and the Cleveland Family ...and meta-analyzed using METAL 52 ... See full document

... a wide variety of tissues and in many malignancies, including 60% of breast tumors and is required for normal mammary gland and bone development 22-25 ...recent study reported that loss of PTHrP accelerates ... See full document

... ASAP study (Advanced Study of Aortic Pathology) was supported by the Swedish Research Council, the Swedish Heart-Lung Foundation, the Leducq Foundation (MIBAVA), and a donation by Fredrik ...GWAS3D ... See full document

... to lupus in European populations ...no association was discovered with the Chinese population (rs2280381, P = ...present study, we identified a new SNP rs2934498 near rs2280381 (D’ = ... See full document

... Biology Unit (C.B.), Department of Medical Biochemistry and Biophysics (J.L.M.B.), Karolinska Institutet, Stockholm, Sweden; Center for Biological Sequence Analysis, Technical University of Denmark, Copenhagen, ... See full document

... GWAS meta-analysis across 2 large consortia with cohorts of European ancestry—the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) and SpiroMeta—to identify common genetic variants ... See full document

... stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases, 6,243 controls) followed by meta-analysis with prior ... See full document

... present study, we have also identified and vali- dated the association between SLE risk locus PTPN22 and the production of antinuclear antibodies and with the presence of a hematologic ...previous ... See full document

... component analysis which included 13 independent SNPs (including the seven described in this study) that had been genotyped in all of our cases and ...this analysis provided a strong separa- tion ... See full document

... and Analysis Group), C.C.A.S. (Data and Analysis Group; Publications Committee), ...and Analysis Group), WTCCC2 (see Acknowledgments in the Supplementary Note for additional contributors not listed ... See full document

... risk loci so far identified for glioma account for 27 and 43% of the familial risk of GBM and non-GBM tumours, respectively, of which ...the loci newly reported in this study (Supplementary Table ... See full document

... Cancer Study and had an ICD coding of malignant neoplasm of the esophagus (C15) and a pathological diagnosis of ...SEARCH study which ascertains eligible cases of breast, ovary, prostate, colorectal, ... See full document

... comprised 2,282 cases (1,060 male; mean age at diagnosis: 64 years) recruited through the UK Medical Research Council (MRC) Myeloma-IX and Myeloma-XI trials. The MM-GER GWAS comprised 1,508 cases (867 male; mean age at ... See full document

... for meta-analyses. Our first pooled genome wide association study (GWAS) performed in prostate cancer survivors demonstrated that it was possible to meta- analyze data and ... See full document

... Regional association plots for four of the ten prioritized SNPs for MHBA phenotypes identified using EduYears as a proxy phenotype: a, cognitive performance; b, hippocampus; c, intracranial volume; d, ...few ... See full document

... combinations: systemic lupus erythematosus (SLE), lupus erythematosus disseminatus, lupus, SLE, Antimalarials, Hydroxychloroquine, chloroquine, lipid (see search strategy for ... See full document

... and Meta-Analyses (PRISMA) statement, relevant studies were carefully retrieved through PubMed, Cochrane library and Web of Science, China National Knowledge Infrastructure, Wanfang database and China Biology ... See full document

... Chorea in systemic lupus erythematosus and ‘lupus-like’ disease: association with anti- phospholipid antibodies. Sem Arthritis Rheum[r] ... See full document