[PDF] Top 20 Genome wide gene based analysis of rheumatoid arthritis associated interaction with PTPN22 and HLA DRB1
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Genome wide gene based analysis of rheumatoid arthritis associated interaction with PTPN22 and HLA DRB1
... Genetic Analysis Workshop 16 Problem 1 consist of 868 cases and 1194 controls from the North Rheumatoid Arthritis Consortium (NARAC), with geno- types on 545,080 ...of gene A had been included ... See full document
5
Genome wide linkage and association analysis of rheumatoid arthritis in a Canadian population
... and PTPN22, despite that the association with PTPN22 has been replicated ...the HLA complex either. Among the 102 SNPs were genotyped in the HLA region, 85 passed our data quality checking, ... See full document
5
Non HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA defined subgroups of rheumatoid arthritis
... of Rheumatoid Arthritis (EIRA) with incident cases of RA and two smaller co- horts of cases with well-established/chronic ...the HLA-DRB1 locus may contribute and shape the development of cer- ... See full document
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Genome wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium
... single-SNP analysis, only five were previously reported to be associated with ...SNPs associated with ...GWAHI analysis discovered interactions between haplotype blocks, especially 39 hub ... See full document
6
Pathway based analysis of a genome wide case control association study of rheumatoid arthritis
... Rheumatoid arthritis (RA) is the most common systemic autoimmune disease characterized by chronic, destruc- tive, and debilitating inflammation of joints and extra- articular tissues ...on ... See full document
5
Effects of covariates and interactions on a genome wide association analysis of rheumatoid arthritis
... for interaction with sex and other environmental variables should be included in future case-control design GWAA in ...cluster analysis changed the outcome of the analysis substantially for some ... See full document
6
Rheumatoid arthritis associated gene gene interaction network for rheumatoid arthritis candidate genes
... Rheumatoid arthritis (RA, MIM 180300) is a chronic and complex autoimmune ...American Rheumatoid Arthritis Consortium (NARAC) data set provided in Genetic Analysis Workshop 16 (GAW16), ... See full document
6
Association of HLA DRB1 and DQB1alleles and haplotypes with rheumatoid arthritis in a Pakistani population
... lished based on the fact that the risk rate is about two to three percent in people who have a close relative with rheumatoid arthritis, such as a parent, brother or sister ...negatively ... See full document
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Evaluation of the rheumatoid arthritis susceptibility loci HLA DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort
... between HLA-DRB1 SE alleles, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/ C5 with susceptibility to autoantibody-positive RA, but only the TRAF1/C5 locus was associated with disease severity in ... See full document
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Classification of rheumatoid arthritis status with candidate gene and genome wide single nucleotide polymorphisms using random forests
... American Rheumatoid Arthritis Consortium (NARAC) candidate gene and genome-wide single-nucleotide polymorphism (SNP) data sets, we applied regression methods and tree-based ... See full document
6
The impact of HLA DRB1genes on extra articular disease manifestations in rheumatoid arthritis
... been associated with the 'shared epitope' (SE) of HLA-DRB1, which includes DRB1*04 and DRB1*01 alleles ...Recent genome-wide scanning studies using microsatellite loci ... See full document
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Genetic polymorphisms in PTPN22, PADI 4, and CTLA 4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene environment interactions with heavy cigarette smoking
... Rheumatoid arthritis (RA) is a systemic autoimmune disease that is characterized by chronic, destructive, and debilitating ...inflammatory arthritis, it affects approximately 1% of the population ... See full document
12
A genome wide ordered subset linkage analysis for rheumatoid arthritis
... been associated with worse outcome in RA, with evidence that there has recently been a shift towards an older age of onset ...like HLA, which might suggest that age has an effect on disease phenotype ... See full document
6
Evidence of linkage to chromosome 1 for early age of onset of rheumatoid arthritis and HLA marker DRB1 genotype in NARAC data
... linkage analysis methods that allow covariates can incorporate only one or few covari- ates and rely on an assumption of linear covariate effects ...onset, HLA-DRB1 genotype, severity, anti-cyclic ... See full document
5
Comparison of methods for correcting population stratification in a genome wide association study of rheumatoid arthritis: principal component analysis versus multidimensional scaling
... the HLA region on chromosome 6, which had been implicated by numer- ous RA studies ...reached genome-wide significance (p-value < ...the analysis using the trend test, 221 for the ... See full document
6
Adjusting for HLA DRβ1 in a genome wide association analysis of rheumatoid arthritis and related biomarkers
... test of genotype-based association and the FP test were implemented in sumstat using 5000 permutations. Genetic analysis of the two biomarkers RFUW and anti- CCP were conducted in a similar fashion, but ... See full document
6
Meta analysis of the association of HLA DRB1 with rheumatoid arthritis in Chinese populations
... was based on unadjusted data, as the al- leles information stratified for the main confounding variables was not available in the original ...different DRB1 SE alleles are common in Asian ...that ... See full document
10
A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis
... DNA analysis were available only from the NSHDS cohort, result- ing in 59 prepatients (45 women and 14 men); the Mater- nity cohort did not include collection of samples for DNA ...sufficient, based on ... See full document
6
A Bayesian genome wide linkage analysis of quantitative traits for rheumatoid arthritis via perfect sampling
... Rheumatoid arthritis is a complex disease caused by a combination of genetic, environmental, and hormonal factors, and their additive and/or non-additive ...linkage analysis to provide evidence of ... See full document
6
Meta Analysis of Genome Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non HLA Shared Loci
... The analysis of gene expression was done on PBMC of 1,469 individuals, as previously described ...component analysis was performed over the sample correlation matrix, in order to capture non-genetic ... See full document
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