[PDF] Top 20 Both Genome Segments Contribute to the Pathogenicity of Very Virulent Infectious Bursal Disease Virus
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Both Genome Segments Contribute to the Pathogenicity of Very Virulent Infectious Bursal Disease Virus
... full-length genome of 94432 was determined, and a reverse genetics system was ...reduced pathogenicity as isolate ...the pathogenicity of ...the virus polymerase (VP1) contributed even more ... See full document
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Pathogenicity And Immunogenicity Of Egg-Adapted Very Virulent Infectious Bursal Disease Virus Isolated In Malaysia
... layer, broiler and indigenous (village) chickens in various areas in West Malaysia during 1993 to 1994. The sequence of the hv region was obtained following total RNA extraction from the wild type UPM 93273 and its ... See full document
25
Adaptation And Attenuation Of Very Virulent Infectious Bursal Disease Virus In Avian And Mammalian Cell Cultures For Vaccine Development
... study. Both isolates were successfully adapted and attenuated in Vero cell cultures of 22 passages throughout the proposed modified ...method, both isolates can be adapted and propagated faster and easier ... See full document
25
Adaptation of Very Virulent Infectious Bursal Disease Virus to Chicken Embryonic Fibroblasts by Site-Directed Mutagenesis of Residues 279 and 284 of Viral Coat Protein VP2
... cloned virus has to be tested, which is a lengthy and labor- intensive ...ventional virus passage ...The genome of the generated virus is known and no virus cloning is ...mutant ... See full document
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A single amino acid V4I substitution in VP1 attenuates virulence of very virulent infectious bursal disease virus (vvIBDV) in SPF chickens and increases replication in CEF cells
... that bursal-derived VP1 cause more severe bursa lesions than tissue culture ...viral pathogenicity, decreasing mortality rates compared to wild-type ...whole pathogenicity equivalent to the original ... See full document
6
Transcriptional profiles in bursal B lymphoid DT40 cells infected with very virulent infectious bursal disease virus
... signals both posi- tively and negatively, was downregulated at 12 and 18 h ...study, both PTK2 and JAK1 were decreased at 12, 18, and 24 h after vvIBDV ... See full document
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Identification and pathogenicity of a natural reassortant between a very virulent serotype 1 infectious bursal disease virus (IBDV) and a serotype 2 IBDV
... cause very high mortality in SPF chickens ( van den Berg et ...to both serotypes of IBDV prior to ...reassorted virus are not pathogenic in turkey ...caused disease in turkeys ( Giambrone et ... See full document
8
Rescue of Very Virulent and Mosaic Infectious Bursal Disease Virus from Cloned cDNA: VP2 Is Not the Sole Determinant of the Very Virulent Phenotype
... B segments which were used to deduce the amino acid sequences can be found in the GenBank database under accession numbers AF240686 and AF194428 (A segments of D6948 and CEF94, respectively) and AF240687 ... See full document
11
Phylogenetic Analysis Reveals a Correlation between the Expansion of Very Virulent Infectious Bursal Disease Virus and Reassortment of Its Genome Segment B
... 2006 Infectious bursal disease virus (IBDV) is a birnavirus causing immunosuppressive disease in ...the very virulent form of IBDV (vvIBDV) in the late 1980s dramatically ... See full document
7
Molecular Characterisation And Pathogenicity Of Infectious Bursal Disease Virus Isolated In Iran
... inoculated into 28-day-old specific pathogen free (SPF) chicken; IR298 isolate did not produce any mortality and the gross lesions in SPF chickens but the bursa of Fabricius was atrophied, whereas IR499 isolate induced ... See full document
25
Pathogenicity And Molecular Characteristics Of Infectious Bursal Disease Virus Isolates Of Nepal
... VP2 is the major structural protein of IBDV responsible for producing neutralising antibodies by the host (Schnitzler et al., 1993: Sharma, et al., 2000). The amino acid changes at VP2 gene are used to differentiate ... See full document
25
Protection of Chickens against Very Virulent Infectious Bursal Disease Virus (IBDV) and Marek's Disease Virus (MDV) with a Recombinant MDV Expressing IBDV VP2
... Although live IBDV vaccines proved highly immuno- genic and effective in chickens (Ismail and Saif, 1991; Tsukamoto et al., 1995b), there are several advantages to the rMDV vaccine developed here. (i) This rMDV is a ... See full document
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Exchange of the C-Terminal Part of VP3 from Very Virulent Infectious Bursal Disease Virus Results in an Attenuated Virus with a Unique Antigenic Structure
... DISCUSSION Outbreaks of vvIBDV pose a continuing threat to the poul- try industry worldwide. Live vaccines currently in use to pre- vent vvIBDV outbreaks are based on adapted field isolates of vvIBDV, the molecular basis ... See full document
10
Molecular Characterization of a very Virulent Infectious Bursal Disease Virus from Iran Demonstrates its Similarity with Recent Isolates from the Middle East
... important disease. A non-enveloped virus from Avibirnavirus genus belongs to the Birnaviridae family is the causative agent (1, ...2).Infectious bursal disease virus (IBDV) is a ... See full document
5
Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV).
... of both cell culture-adapted and very virulent strains of ...IBDV genome segment A (corresponding to the VP4 gene) was amplified by quantitative PCR ... See full document
13
Simultaneous detection of vaccinal and field infectious bursal disease viruses in layer chickens challenged with a very virulent strain after vaccination
... of both vi- ruses during the course of an IBDV infection in the ...pathogenic virus multiplies in the presence of a vaccine strain infection and for how long it could be detected in immunised ... See full document
10
Relationship between Virus Replication and Apoptosis Events in IgM + Cells from Chicken Spleen and Bursa of Fabricius Infected with Malaysia Strain of Very Virulent Infectious Bursal Disease Virus
... Very virulent strains of IBDV caused not only immunosuppresion in chickens [10,15] but also variable mortality in chicken flock ...the virus suppression of interferon and intrusion of the pathway ... See full document
9
Recombinant Infectious Bursal Disease Virus Carrying Hepatitis C Virus Epitopes
... were very similar to those for the wild-type IBDV and that the final virus yields in Vero cells were ...of both segments were placed such that transcription from the CMV promoter starts at the ... See full document
7
Identification and assessment of virulence of a natural reassortant of infectious bursal disease virus
... reassortant infectious bursal disease virus in Eastern ...genomic segments originating from two parental strains with distinct pathotypes (very virulent and classical ... See full document
11
Infectious bursal disease virus in poultry: current status and future prospects
... Besides biosecurity, vaccination is the most important measure to control IBDV in the field. Classical and variant strains have been used for many years, but extensive usage of live vaccines in the field is thought to ... See full document
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