[PDF] Top 20 A Genome Wide Association Study for Longevity in Cattle

... values close to the Bonferroni line, at bp positions 63,641,401 to 64,227,687. This is a gene rich region contain- ing, among others, E2F1 (bp position 63,704,817 - 63,714,008) which has a role in tumor necrosis [38]. ... See full document

... Indeed, previous studies have reported that the SNPs within the SCD gene showing significant associations with C18:1 cis-13 of Canadian commercial steers as well as in Spanish breeds [51]. The heritability for eight FA ... See full document

... current study do not corroborate those of Finlay et ...greater genome coverage, and larger amount of underlying epidemiological ...our study is based on the phenotypes of several thousand animals (n ... See full document

... No animal experiments were performed in this study, and ethics committee approval was therefore not required. We collected ten semen straws from eight healthy and representative Holstein bulls, including six ... See full document

... GWAS study on cattle meat quality, reported by Bolormaa et ...beef cattle were used in this study and 87 SNPs with sig- nificant effects on meat quality (intramuscular fat per- centage) were ... See full document

... The most important issue in a case-control study is how to define cases and controls, and this is particu- larly so in psychiatric genetics. This is more difficult to define and measure than for most non-psychiatric ... See full document

... co-localised at the gene level. We found significant associations between DDH and the GDF5, UQCC1, MMP24, RETSAT and PDRG1 genes. The results of functional look up, LD calculations and after removing the GDF5 locus from ... See full document

... three genome-wide association studies (GWAS) to identify loci that a) increase susceptibility to an AD and subsequent psychotic symptoms; or b) modify risk of psychotic symptoms in the presence of ... See full document

... The magnitude of the genetic and environmental sources of variance in breastfeeding behavior were explored in a pre- vious study in a cohort of Spanish twins from the Murcia Twin Registry (Ordo˜ nana et al., 2006, ... See full document

... Genome-wide association study identifies multiple loci associated with bladder cancer risk. 704[r] ... See full document

... Genome wide association studies (GWAS) are genetic studies in which dense array of genetic markers that capture substantial proportion of common variations in the genome sequence are typed in ... See full document

... new association signal 48 ...this association signal is entirely captured by rs3731249 (P-values before and after conditioning: ...significant association was detected in this ... See full document

... Genome-wide association studies often collect multiple phenotypes for complex ...score-based association test to incorporate family structure, apply different approaches to analyze multiple ... See full document

... the results are applicable to other groups of obese patients? Cotsapas et al proposed that severe obesity in most cases is a condition at the extreme of the phenoty- pic spectrum rather than a distinct condition, which ... See full document

... sequence-based association study in the Icelandic population led to the discovery of rs78378222 at ...The association with glioma was confirmed in an independent European study ...the ... See full document

... NMR study showed that eight loci (LIPC, CETP, PLTP, FADS1, -2, and -3, SORT1, GCKR, APOB, APOA1) were associated with specific lipid subfractions (for example, chylomicrons, low­density lipoprotein (LDL), HDL), ... See full document

... Whole genome associations were calculated with PLINK (allelic chi-square test without covariates, and by logistic regression with age, sex, and AD-pathology as co-variates ...Haplotype association and link- ... See full document

... Genome wide analysis of the association between the TB EBV and each SNP was performed after correcting for the underlying population ...The genome wide Manhattan plot displaying the ... See full document

... two-stage association mapping framework, there are different methods that can be applied to integrate SNP information within a gene, for example, combination of test statistics, principal-com- ponents analysis, ... See full document

... While coding variants were also found at a higher fre- quency in sporadic MSA compared to controls, this finding did not replicate outside of Japanese MSA samples. We investigated the COQ2 locus for common variation in ... See full document