[PDF] Top 20 Globin genes on the move
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Globin genes on the move
... β-globin genes are present in the platypus DS locus [2,15], which seems similar to the embryonic ε -globin and adult β -globin pair found in marsupials ...-globin genes are more ... See full document
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Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals
... To remove DNA contamination, RNAs derived from adult male platypus liver, kidney, spleen, testis, brain and lungs were DNase treated using a DNA-free™ kit according to the manufacturer's instructions (Applied Biosystems, ... See full document
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Genotype phenotype association analysis identifies the role of α globin genes in modulating disease severity of β thalassaemia intermedia in Sri Lanka
... α globin genotype and copy number and known genetic modifiers of haemoglobin F ...α globin gene ...α globin genes in β thalassaemia heterozygotes or α globin gene deletions in β ... See full document
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Analysis of 5' flanking regions of the gamma globin genes from major African haplotype backgrounds associated with sickle cell disease
... gamma-globin genes may account for differences in fetal hemoglobin expression among the three ...fetal globin genes from one beta s-containing chromosome on each of the three major ... See full document
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Altitudinal Variation at Duplicated β-Globin Genes in Deer Mice: Effects of Selection, Recombination, and Gene Conversion
... linked genes contribute to fi tness ...b-globin genes of deer mice (Peromyscus maniculatus), which contribute to adaptive differentiation in blood – oxygen af fi nity between high- and low-altitude ... See full document
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Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure
... α-globin genes along with the remote regu- latory ...(erythroid) genes is located within an extended cluster of housekeeping genes [10, ...alpha-globin genes transcribed in ... See full document
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Organization of the alpha globin genes in the Chinese alpha thalassemia syndromes
... alpha-globin genes of normals are at two loci located on a ...alpha- globin locus is deleted and the single 3' alpha-globin locus is found on a ...alpha-globin genes on a ... See full document
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Quantitation of human gamma globin genes and gamma globin mRNA with purified gamma globin complementary DNA
... human globin mRNA and recovering the single- stranded cDNA from ...gamma globin mRNA and the lack of hybridization to RNA samples containing little, if any, gamma-globin ...gamma-globin ... See full document
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Coexistence of multiple globin genes conferring protection against nitrosative stress to the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125
... 33 The genome of the Antarctic cold-adapted bacterium Pseudoalteromonas haloplanktis 34 TAC125 PhTAC125 contains genes encoding three distinct single-chain 2/2 globins, supporting 35 the[r] ... See full document
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Activation of the human beta globin promoter in K562 cells by DNA sequences 5' to the fetal gamma or embryonic zeta globin genes
... consistent with the known inactivity of the beta-globin gene in these cells. In contrast, a gamma/beta promoter composed of a gamma fragment spanning positions -408 to -137 joined to the 127-bp beta promoter was ... See full document
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Genetic differences in hemoglobin function between highland and lowland deer mice
... HBB genes were sequenced at 12 ⫻ coverage and the haplotype phase of all variable sites was determined ...-globin genes, we used the same RT-PCR primer pair for HBB-T1 and HBB-T2 (forward: ... See full document
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Molecular basis for nondeletion alpha thalassemia in American blacks Alpha 2(116GAG UAG)
... An American black woman was found to have the phenotype of moderately severe alpha- thalassemia normally associated with the loss of two to three alpha-globin genes despite an alpha-globin gene map ... See full document
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Compensatory increase in alpha 1 globin gene expression in individuals heterozygous for the alpha thalassemia 2 deletion
... these genes (alpha-thalassemia [Thal]) have not been directly ...alpha-globin genes by determining the relative levels of alpha 1 and alpha 2 mRNA in the reticulocytes ... See full document
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The evolution of haemoglobin gene loci in amniotes
... active globin genes (Weatherall, 1991). The genes in these clusters are arranged in their order of expression: HBZ and HBE are expressed in an embryo followed by HBG in the foetus and then HBA, HBD ... See full document
206
Molecular basis of alpha-thalassemia
... Other mutations may alter the structure of the globin chain a ff ecting the stability of the αβ-dimer or tetramer. A few examples of highly unstable Hb variants are Hb Evora, Hb Heraklion, Hb Dartmouth, Hb Quong ... See full document
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Polymorphism and Gene Conversion in Mouse α-Globin Haplotypes
... coding regions.. G., 1974 Rodent hemoglobin structure: a comparison of several species of mice. Assignment of orthol- ogous relationships among mammalian a-globin genes by ex- a[r] ... See full document
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Rapid and reliable detection of α-globin copy number variations by quantitative real-time PCR
... In our laboratory, all samples referred for hemoglo- binopathy evaluation undergo standard evaluation, including complete blood count, measurement of serum or plasma ferritin concentrations, HPLC analysis of hemoglobin ... See full document
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The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate
... Various transcription factors related to erythropoiesis and the regulation of hemoglobin expression have been identified [5, 11]. In this study, the up-regulation of Klf1 and Klf2 was detected in the BM and liver. ... See full document
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Insights Into Terminal Erythropoiesis Influenced By Human Genetic Variation
... 2008). In contrast, adult erythropoiesis normally remains at steady state in the absence of a hematopoietic stressor such as hemorrhage or hemolysis. The first wave, the primitive wave, begins in the yolk sac and yields ... See full document
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A New Method to Digitize DNA Sequence
... In this section, a 39-dimension vector is constructed consisting of all the de- scriptors in the three characteristic sequences for the exon-1 of β -Globin genes of eight species in Table 3. Using these ... See full document
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