[PDF] Top 20 Harnessing the potential of epigenetic therapy to target solid tumors

... 5-azacitidne therapy was administered to patients with solid tumors, focusing initially on the biggest killer, advanced, heavily pretreated, non–small-cell lung cancer (NSCLC) ...in solid ... See full document

... Moreover, these techniques, which underlie various complex computer-based optimi- zation algorithms, allowed the delivery of nonuniform radiation beam intensities in order to obtain highly conformal dose distributions, ... See full document

... The potential advantages of Onivyde, a novel nanoliposomal formulation of irinotecan, include improvement of pharma- cokinetics and biodistribution, extension of the circulation time, increase in passive targeting ... See full document

... great potential of ...huge potential of nanotechnology to the practical needs of medical ...and potential interactions with biological processes remain major ... See full document

... a potential therapeutic method to control tumor growth as this study reported [74, ...a potential therapeutic approach for HER2 + ma- lignancies ...specifically target and kill HER2-positive tumor ... See full document

... the potential for targeted therapy and genetic selection of ...maintenance therapy for high-risk, genetically susceptible patients following standard ... See full document

... therapeutic target for EOC and non-small-cell lung ...combination therapy and farletuzumab for patients with recurrent EOC, improvement in progression-free survival was not statistically ...full ... See full document

... We based our study on the assumption that bacteria which had extensively proven their safety as oral probiotics would also sustain safety when applied systemically for tumor therapy. This turned out to be only ... See full document

... cytotoxic therapy by means of their inhibition of DNA repair and ...inhibitory potential than the currently FDA approved HDAC ...specific solid tumor types as well as to identify appropriate ... See full document

... Multispecific CAR-T cells have a potential advantage over unispecific CAR-T cells in avoiding on-target/off-tumor toxicities [49]. In lymphoreticular malignancies, instead of CRS, multispecific CAR-T cells ... See full document

... of solid tumors and their microenvironment that affect tumor penetration and distribution is a key requirement to improve clinical outcomes and realize the full potential of monoclonal antibodies in ... See full document

... First-generation epigenetic inhibitor drugs have obtained modest clinical results in two types of hematological ...Second-generation epigenetic inhibitors are in development, and have intrinsically greater ... See full document

... Though there are no clinical trials regarding CXCR3-targeted therapy currently, it is, indeed, a potential target and more studies are required to verify this. In most cases, chemokines are released ... See full document

... molecular target in cancer therapy due to its critical role in cellular protein degradation, interaction with cell cycle and apoptosis regulation, and unique mechanism of ...relevant target in ... See full document

... As the first step to identify putative therapeutic targets for advanced PCa, we analyzed the expression of PcG genes in the LTL313H/LTL313B PDX model of meta- static and non-metastatic PCa [29]. LTL313H and LTL313B ... See full document

... Muscle type of pyruvate kinase (PKM) is one of the key mediators of the Warburg effect and tumor metabolism. PKM1 and PKM2 are two major isoforms, which are alternative splice products of the PKM gene. PKM2 is ... See full document

... most solid tumors are classified as low risk for TLS, whereas tumors which are sensitive to chemotherapy or have high- proliferative index, such as neuroblastomas, germ cell, and small-cell lung ... See full document

... questions around what data to collect and how, the critical issue is ensuring that data is made available and accessible to the range of people who will benefit from it (educators, school leaders, governance bodies, ... See full document

... potential antivirulence agents for Gram-negative bacteria. 16 Flagellin proteins giycosylated with pseudaminic acid (Pse) is critical in the pathogenicity of Helicobacter pylori, small molecule compounds targeting ... See full document

... PME is a very rare neoplasm and only few reports describe this entity (see Table 2 for more details) [5-9]. Similar to classical ME, surgery in PME, with or without systemic chemotherapy and/or local radiotherapy, repre- ... See full document