[PDF] Top 20 The Herpes Simplex Virus gE-gI Complex Facilitates Cell-to-Cell Spread and Binds to Components of Cell Junctions
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The Herpes Simplex Virus gE-gI Complex Facilitates Cell-to-Cell Spread and Binds to Components of Cell Junctions
... Herpes simplex virus (HSV) replicates in tissues of epithelial origin such as the oral and genital mucosae and corneal epi- ...extensive cell contacts or junctions, and HSV and other ... See full document
10
The Herpes Simplex Virus 1 UL51 Gene Product Has Cell Type-Specific Functions in Cell-to-Cell Spread
... on gE function and localization. pUL11 binds directly to the gE cytoplasmic tail, where pUL11, pUL16, and pUL21 form a complex that is required for proper gE trafficking to cell ... See full document
11
The Extracellular Domain of Herpes Simplex Virus gE Is Indispensable for Efficient Cell-to-Cell Spread: Evidence for gE/gI Receptors
... Herpes simplex virus (HSV) spreads rapidly and efficiently within epithelial and neuronal ...heterodimer gE/gI plays a critical role in promoting cell-to-cell ... See full document
12
Structure-function analysis of the gE-gI complex of feline herpesvirus: mapping of gI domains required for gE-gI interaction, intracellular transport, and cell-to-cell spread.
... The gI-152 product, which is only 14 resi- dues shorter than gI D M, and even gI D P, which is truncated at residue 93, still associate with gE, as demonstrated by coim- ...of herpes ... See full document
8
Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells.
... Replication of gE- and gI - mutant viruses in human fibroblasts were normal, and the rates of entry of mutant and wild-type viruses into fibroblasts were similar; however, spread of gE -[r] ... See full document
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Cytoplasmic Domain of Herpes Simplex Virus gE Causes Accumulation in the trans-Golgi Network, a Site of Virus Envelopment and Sorting of Virions to Cell Junctions
... PrV gE/gI functions in envelopment of nucleocapsids in the cyto- plasm ...lacking gE, or the CT domain of gE, as well as second glycoprotein, gM, accumulated large numbers of unenveloped ... See full document
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Herpes Simplex Virus gE/gI Must Accumulate in the trans-Golgi Network at Early Times and Then Redistribute to Cell Junctions To Promote Cell-Cell Spread
... 49). gE/gI TGN localization appears to be important for virus assembly and as a first step towards the selective sorting of enveloped particles to cell junctions, which promotes ... See full document
13
Herpes Simplex Virus gE/gI Extracellular Domains Promote Axonal Transport and Spread from Neurons to Epithelial Cells
... the spread of herpes simplex virus (HSV) from infected neu- rons to epithelial cells: (i) anterograde axonal transport of virus particles from neuron bodies to axon tips and (ii) ... See full document
9
Herpes Simplex Virus 1 pUL34 Plays a Critical Role in Cell-to-Cell Spread of Virus in Addition to Its Role in Virus Replication
... of herpes simplex virus (HSV) during recur- rent disease in the host is dependent upon efficient viral rep- lication and on the ability of the virus to spread from cell to ... See full document
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Redistribution of Cellular and Herpes Simplex Virus Proteins from the Trans-Golgi Network to Cell Junctions without Enveloped Capsids
... Herpes simplex virus (HSV) and other alphaherpesviruses assemble enveloped virions in the trans-Golgi network (TGN) or ...and virus particles are subsequently ferried to the plasma membrane in ... See full document
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Herpes Simplex Virus gE/gI Sorts Nascent Virions to Epithelial Cell Junctions, Promoting Virus Spread
... alphaherpesviruses spread effectively from cell to cell in solid tissues are poorly ...Since gE/gI functions selectively in this process, and not in entry of extracellular virus ... See full document
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The Extracellular Domain of Herpes Simplex Virus gE Is Sufficient for Accumulation at Cell Junctions but Not for Cell-to-Cell Spread
... of gE/gI into the ...the virus was removed and media containing 1% FBS were ...the cell culture supernatants were removed and centrifuged at 3,750 rpm for 15 min in a Beckman GS6 rotor to ... See full document
10
Herpes Simplex Virus gE/gI Expressed in Epithelial Cells Interferes with Cell-to-Cell Spread
... of gE and gI participate in cell-to-cell spread by binding to compo- nents of cell junctions (21, 23, 31, ...48). gE/gI preferentially accumulates at lateral ... See full document
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Deletion of the First Cysteine-Rich Region of the Varicella-Zoster Virus Glycoprotein E Ectodomain Abolishes the gE and gI Interaction and Differentially Affects Cell-Cell Spread and Viral Entry
... VZV gE shares the formation of noncovalently linked gE/gI het- erodimers with its homologues in these related viruses (22, 26, 61, ...only gE and gI, whereas the other ... See full document
13
Regulation of Herpes Simplex Virus Glycoprotein-Induced Cascade of Events Governing Cell-Cell Fusion
... affect virus infection of certain cell types ...on cell-cell fusion mediated by the wt glycoproteins or any combina- tion of the deregulated proteins ... See full document
10
Transcriptional targeting of herpes simplex virus for cell-specific replication.
... of virus as indicated. After removal of virus inoculum, the cells were incubated in Dulbecco’s modified Eagle’s medium supplemented with 1% IFCS and ...hybridoma cell line 58S (ATCC HB8183) (66), ... See full document
9
The equine herpesvirus 1 glycoprotein gp21/22a, the herpes simplex virus type 1 gM homolog, is involved in virus penetration and cell-to-cell spread of virions.
... different cell lines. To characterize the growth of the gM-negative L11 D gM virus, three separate experiments were ...per cell) with L11 D gM or RacL11, and at different times p.i., virus ... See full document
6
Effect of ultrasound on herpes simplex virus infection in cell culture
... several vectors are under clinical trials [5-7]. A draw back of oncolytic virotherapy for solid tumors is the efficiency of infection. Many factors affect an infection. One impor- tant characteristic of the tumor ... See full document
9
Role of cell-associated enveloped vaccinia virus in cell-to-cell spread.
... Cell-associated virus A and B, virus released to the medium by trypsin C and D, and extracellular virus E and F were isolated from WR-infected cells A, C, and E or IHD-J infected cells B[r] ... See full document
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Heparan Sulfate Proteoglycan Binding by Herpes Simplex Virus Type 1 Glycoproteins B and C, Which Differ in Their Contributions to Virus Attachment, Penetration, and Cell-to-Cell Spread
... wild-type virus to mutant cells defective for HS expression (17, 23, ...of virus attachment compared to gB null virion particles (4, ...the cell surface membrane ...with virus entry and ... See full document
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