[PDF] Top 20 Herpes Simplex Virus Types 1 and 2 Differ in Their Interaction with Heparan Sulfate

... the virus binding to cells (49; Mårdberg et al., submitted). An entire gC-1 segment that is lo- cated N terminally to the HS-binding domain (amino acids 26 through 113) represents in fact a mucin-like ... See full document

... cell interaction and in the alternate receptors used by the gD in- terference escape ...binding interaction with the cell surface prior to entry, but gB and gH play some essential role both in post- ... See full document

... wild-type virus, suggesting that only gB binding to the HS receptor is required for efficient intercellular infection and indicating that the roles of HS binding are different in extra- and intercellular ...the ... See full document

... Herpes simplex virus type 1 (HSV-1) infection of the corneal stroma remains a major cause of ...(3-OS) heparan sulfate (HS)-generating enzyme 3-O sulfotransferase 3 ... See full document

... edge concerning the epidemiology and control of HSV-2, and its interaction with HIV. Experts concluded that estimates of HSV and HIV infections were needed by sex and age group in order to explore possible ... See full document

... to determine whether of one DISCUSSION Our results demonstrate that the initial step in infection of HEp-2 cells by HSV-1 and HSV-2 is binding of virions to Downloaded from http://jvi.as[r] ... See full document

... ␤ 1 is a cellular receptor for Kaposi’s sarcoma- associated herpesvirus ...Human herpes virus 7 utilizes CD4 as a receptor for infection, although gB does not bind to CD4 (36, ...this ... See full document

... influenza virus binds to the terminal carbohydrate side chain sialic acids on cells, leading to endocytosis of virions ...of virus particles inside cells (11, 22, 29, ...immunodeficiency virus and ... See full document

... erpes simplex virus 2 (HSV-2) is responsible for approxi- mately two-thirds of the sexually transmitted mucocutane- ous lesions commonly known as genital herpes in the United States, ... See full document

... HSV-1 neutral-pH entry through a cascade of virus-cell interactions that trigger cell surface fusion 7, 35, 41 is consistent with the presence of at least two types of receptors on susce[r] ... See full document

... keratin sulfate were ob- tained from Sigma-Aldrich ...of 2, 4, 6, 8, 10, 14, and 20 subunits and control saccharide (decasaccharide containing the pen- tasaccharide antithrombin III-binding site) were ... See full document

... the interaction between VP16 and VP1/2 during infection, cells were infected with the HSV-VP16(K343A) mutants and their re- spective wt ...VP16(K343A) virus or the K⌬UL36 virus that contains a ... See full document

... COHEN* Department of Microbiology, School of Dental Medicine, University of Pennsylvania and Center for Oral Health Research, Philadelphia, Pennsylvania 19174 Deoxyribonucleoside triphos[r] ... See full document

... There are several possible explanations for the absence of receptor activity in these mutant proteins: i residues 219 to 244 and 318 to 346 are contact residues in the C3b-binding site; [r] ... See full document

... Secondly, in all countries, a steady increase in the proportion HSV-1 seropositive occurred with age group (fig 2). In multivariable analysis for each country, almost all age groups were significantly more ... See full document

... their interaction with heparin [113, 114] ...the interaction with HS of other ...the interaction of antithrombin III with for a pentasaccharide structure in heparin, contends that there are rare and ... See full document

... varicella-zoster virus, cytomegalovirus, Epstein- Barr virus, human herpesvirus 6, Haemophilus influenzae, Neisseria meningitidis, Cryptococcus neoformans, and hepatitis B virus were obtained from ... See full document

... In this study, only African women infected with both HSV-1 and HSV-2 were selected for genital antibody studies. Rates of HSV-1 and HSV-2 seroprevalence are very high in Central Africa. ... See full document

... Anti- herpes B virus macaque serum and anti-HSV-1 and anti- HSV-2 rabbit and human sera were investigated for their re- activities to gG-1 or gG-2 by the fluorometric indirect ... See full document

... A recent study of the structural polypeptides specified by 53 different HSV-1 strains revealed that certain polypeptide bands with characteristic electrophoretic mobilities in SDS gels w[r] ... See full document