[PDF] Top 20 Herpes simplex virus virion host shutoff function.
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Herpes simplex virus virion host shutoff function.
... KRUPER, AND NIZA FRENKELt* Department of Molecular Genetics and Cell Biology, the University of Chicago, Chicago, Illinois 60637 Received 14 August 1987/Accepted 2 December 1987 Infectio[r] ... See full document
10
The herpes simplex virus virion host shutoff function.
... The lack of host shutoff at an input MOI of 2 PFU of KOS virus in the presence of dactinomycin per cell was also observed in additional experiments in which the level of host cell protei[r] ... See full document
6
Inhibition of the Host Translation Shutoff Response by Herpes Simplex Virus 1 Triggers Nuclear Envelope-Derived Autophagy
... ␣ virus that carries Val178Glu and Phe180Leu substitutions was constructed by amplifying nucleotides 463 to 1088 of HSV-1 by PCR from wild-type (wt) strain 17syn⫹ infectious DNA with primers 5=-CAGACC ... See full document
8
The Virion Host Shutoff RNase Plays a Key Role in Blocking the Activation of Protein Kinase R in Cells Infected with Herpes Simplex Virus 1
... total shutoff of protein ...the virus life cycle (reviewed in reference 9). In the case of herpes simplex virus 1 (HSV-1), a viral gene, designated ␥ 1 ... See full document
6
The Splicing History of an mRNA Affects Its Level of Translation and Sensitivity to Cleavage by the Virion Host Shutoff Endonuclease during Herpes Simplex Virus Infections
... Recent studies, primarily from the Smiley laboratory, have re- ported instances in which Vhs stimulates the translation of spe- cific mRNAs instead of degrading them (20–23). These include mRNAs containing several ... See full document
13
A Single Amino Acid Substitution in Herpes Simplex Virus Type 1 VP16 Inhibits Binding to the Virion Host Shutoff Protein and Is Incompatible with Virus Growth
... In conclusion, the results presented here demonstrate that VP16 serves to block vhs activity through a direct interaction, an association that is ultimately required for virus production. The finding that the ... See full document
11
Small Interfering RNAs That Deplete the Cellular Translation Factor eIF4H Impede mRNA Degradation by the Virion Host Shutoff Protein of Herpes Simplex Virus
... The herpes simplex virus (HSV) virion host shutoff (Vhs) protein is an endoribonuclease that accelerates decay of many host and viral ... See full document
10
Disruption of Virion Host Shutoff Activity Improves the Immunogenicity and Protective Capacity of a Replication-Incompetent Herpes Simplex Virus Type 1 Vaccine Strain
... vaccinated host or latent infection in the nervous system ...petent virus remains a concern, however, because production of immunogenic viral proteins is limited to cells initially in- fected by the vaccine ... See full document
8
Mutational analysis of the herpes simplex virus virion host shutoff protein: evidence that vhs functions in the absence of other viral proteins.
... trigger shutoff, then it should strongly inhibit expression of an other- wise constitutively active b -galactosidase reporter gene in co- transfected mammalian cells (through a combination of direct and indirect ... See full document
9
mRNA Degradation by the Virion Host Shutoff (Vhs) Protein of Herpes Simplex Virus: Genetic and Biochemical Evidence that Vhs Is a Nuclease
... Site-directed mutagenesis of Vhs. If one believes that the sequence similarities shared by Vhs and the cellular and phage FIG. 2. Sequences of the amino-terminal and internal domains of Vhs and selected cellular ... See full document
12
The Herpes Simplex Virus 1 Virion Host Shutoff Protein Enhances Translation of Viral Late mRNAs by Preventing mRNA Overload
... smaller positive effect of earlier expression and/or increased accumulation of the US11 protein on translation of other late proteins. US11 is an RNA-binding protein that binds to and inhibits activation of the ... See full document
9
Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function.
... 10 0022-538X/94/$04.00+0 Copyright C 1994, American Society for Microbiology Improved Cell Survival by the Reduction of Immediate-Early Gene Expression in Replication-Defective Mutants o[r] ... See full document
16
Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras.
... lytic herpes simplex virus (HSV) infections, the half-lives of host and viral mRNAs are regulated by the HSV virion host shutoff (Vhs) protein ...the host more ... See full document
10
Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage
... The accrued results of numerous studies carried out in the past decade have shown that in cells infected with wild-type HSV-1, VHS selectively targets the AU-rich mRNAs. These mRNAs are made in copious amounts as a ... See full document
8
The vhs1 Mutant Form of Herpes Simplex Virus Virion Host Shutoff Protein Retains Significant Internal Ribosome Entry Site-Directed RNA Cleavage Activity
... vhs function. The vhs1 mutation abolishes early shutoff of host protein synthesis during HSV infection (20) and eliminates vhs activity in transient cotransfection assays (12, ... See full document
5
Therapeutic Immunization with a Virion Host Shutoff-Defective, Replication-Incompetent Herpes Simplex Virus Type 1 Strain Limits Recurrent Herpetic Ocular Infection
... renewed virus shedding and corneal disease has also been demonstrated in the rabbit eye model of spontaneous ocular HSV recurrence after glycoprotein vaccine therapy ... See full document
11
Expression and function of the equine herpesvirus 1 virion-associated host shutoff homolog.
... of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2, respectively) to repress host cell protein synthesis early in infection has been studied extensively and found to involve the activities ... See full document
9
Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides.
... The vhs mutants appeared to be defective also with respect to post-transcriptional shutoff of a immediate early viral gene expression, since i cells infected with mutant viruses overprod[r] ... See full document
15
Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide.
... To identify the vhs UL41 polypeptide within infected cells and virions, antisera raised against a UL41-lacZ fusion protein were used to characterize the polypeptides encoded by wild-type[r] ... See full document
12
Picornavirus Internal Ribosome Entry Site Elements Target RNA Cleavage Events Induced by the Herpes Simplex Virus Virion Host Shutoff Protein
... The IRES targeting function does not require ribosomes. vhs-induced RNA degradation occurs in the presence of agents that block translational initiation and elongation in HSV-1- infected cells (13, 59, 67), and ... See full document
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