[PDF] Top 20 Human cytotoxic T-cell memory: long-lived responses to vaccinia virus.
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Human cytotoxic T-cell memory: long-lived responses to vaccinia virus.
... to long-lived, specific T-cell memory? One mechanism that has been suggested is immunological cross- reactivity between viruses (2, 21, ...study virus cross-reactive ... See full document
5
Human Memory Cytotoxic T-Lymphocyte (CTL) Responses to Hantaan Virus Infection: Identification of Virus-Specific and Cross-Reactive CD8+ CTL Epitopes on Nucleocapsid Protein
... Hantaan virus results in the development of both Hantaan virus-specific and hantavirus cross-reactive T-cell ...Nombre virus-specific CTL lines established in our labo- ratory included ... See full document
8
HLA Class I-Restricted T-Cell Responses May Contribute to the Control of Human Immunodeficiency Virus Infection, but Such Responses Are Not Always Necessary for Long-Term Virus Control
... ⫹ T-cell ...potent T-cell response against one or more highly conserved viral epitopes, viral escape against these responses is not associated with viral rebound (1, 3, 20, 21, 25, ... See full document
10
Long-Term Control of Simian Immunodeficiency Virus Replication with Central Memory CD4+ T-Cell Preservation after Nonsterile Protection by a Cytotoxic T-Lymphocyte-Based Vaccine
... of virus-specific CD8 ⴙ cytotoxic T-lymphocyte (CTL) responses is a promising strategy for AIDS vaccine ...how long-term viral containment and disease control are attainable by ... See full document
10
Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells
... to cytotoxic and proliferative capacities (26, 48). Such polyfunctional T cells were recently correlated with control of HIV infection (1, 6), response to HIV vaccines (24, 41), and antiretroviral therapy ... See full document
15
Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes.
... antiviral cell-mediated immunity of rLM-vaccinated mice was substantially increased by secondary ...immune responses to novel ...to vaccinia virus can persist for more than 15 years, and ... See full document
9
Evaluation of Cytotoxic T-Lymphocyte Responses in Human and Nonhuman Primate Subjects Infected with Human Immunodeficiency Virus Type 1 or Simian/Human Immunodeficiency Virus
... with vaccinia virus for ...infectious vaccinia virus in the culture can provide a continu- ous supply of antigen to drive T effector cell proliferation and expansion (Table 2), ... See full document
10
Kinetics of Recombinant Adenovirus Type 5, Vaccinia Virus, Modified Vaccinia Ankara Virus, and DNA Antigen Expression In Vivo and the Induction of Memory T-Lymphocyte Responses
... the long-term immune responses elicited. As memory T-cell responses are derived from the same cell populations as primary T-cell responses (24), there ... See full document
6
Induction of Long-Term Memory CD8+ T Cells for Recall of Viral Clearing Responses against Influenza Virus
... of cytotoxic T-cell-mediated virus-clearing responses by influenza virus T cell determinant-con- taining peptide immunogens was ...viral-clearing responses ... See full document
10
Impact of Cytotoxic-T-Lymphocyte Memory Induction without Virus-Specific CD4+ T-Cell Help on Control of a Simian Immunodeficiency Virus Challenge in Rhesus Macaques
... eliciting virus-specific T-cell responses, whether induction of these memory T cells by vaccination before human immunodeficiency virus (HIV) exposure can actually ... See full document
8
Levels of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Effector and Memory Responses Decline after Suppression of Viremia with Highly Active Antiretroviral Therapy
... CTL responses to a dominant epitope in the envelope ...against vaccinia virus- infected target cells, this response also rose again after a tran- sient rise in viral load at day 294, when direct ... See full document
8
Expansion and Exhaustion of T-Cell Responses during Mutational Escape from Long-Term Viral Control in Two DNA/Modified Vaccinia Virus Ankara-Vaccinated and Simian-Human Immunodeficiency Virus SHIV-89.6P-Challenged Macaques
... of T-cell function and exhaustion. During the long period of viral control, all vaccinated animals, includ- ing animals 4 and 5, had low frequencies of IFN- ␥ responses with good proportions ... See full document
5
Human T-Cell Responses to Vaccinia Virus Envelope Proteins
... live vaccinia virus ...elicit T-cell responses, as well as neutralizing antibodies, will be important to include in a molecular ...VACV-specific memory T-cell ... See full document
11
Virus-Specific CD4+ and CD8+ Cytotoxic T-Cell Responses and Long-Term T-Cell Memory in Individuals Vaccinated against Polio
... is long lasting, we were able to recover T cells from all of our donors, who were vaccinated over two decades before our studies were ...PV-specific T cells from uvPV-loaded M suggests that these ... See full document
8
CD4+ T Cell Help Is Dispensable for Protective CD8+ T Cell Memory against Mousepox Virus following Vaccinia Virus Immunization
... for cell surface molecules, fixed, permeabilized, and stained for intracellular molecules using the Cytofix/Cytoperm kit (BD Biosciences) according to the manufacturer’s ...epitope-specific T cells, ... See full document
8
Modulation of T-Cell Responses to a Recall Antigen in Human T-Cell Leukemia Virus Type 1-Infected Individuals
... The hyporesponsiveness to PPD in both HTLV-1-positive and -negative groups appeared to be specific for PPD, since PHA responses were comparable in all groups as previously observed in vivo (9). Analysis of ... See full document
5
Dynamics of T-Cell Responses and Memory T Cells during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques
... ⴙ T-cell, CD8 ⴙ T-cell, and B-cell ...⫹ T-cell counts were determined in 30- l aliquots of whole blood by immunostaining with anti-CD3-fluorescein isothiocyanate (FITC; ... See full document
13
Cytotoxic T-cell response to respiratory syncytial virus in mice.
... We report here the finding of major histocompatibility complex-restricted, RSV-specific memory cytotoxic T cells in the spleens of BALB/c and C57BL mice after intranasal infection; these[r] ... See full document
5
Human Survivors of Disease Outbreaks Caused by Ebola or Marburg Virus Exhibit Cross-Reactive and Long-Lived Antibody Responses
... Sudan virus (SUDV), Ebola virus (EBOV), Bundibugyo virus (BDBV), Taï Forest virus (TAFV) ebolavirus, and Marburg marburgvirus (MARV) are the cause of these severe human infec- ...Ebola ... See full document
8
Superior T memory stem cell persistence supports long lived T cell memory
... identified T cells with a T SCM phenotype and stem cell–like properties in nonhuman ...least-differentiated memory subset, were functionally distinct from conventional memory cells, and ... See full document
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