[PDF] Top 20 The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release.
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The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release.
... Because of its structural similarity to the membrane protein M2 encoded by influenza virus and the previously reported 4- to 10-fold reduction in progeny virion production associated wit[r] ... See full document
9
The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation.
... to Vpu (10, 27, ...abrogated Vpu binding. Since the ability of the CD4 deletion mutants to bind Vpu correlated with their sensitivity to degradation, it is unlikely that, in the case of CD4, a major ... See full document
11
Vpr Is Required for Efficient Nef Expression from Unintegrated Human Immunodeficiency Virus Type 1 DNA
... is required for efficient HIV-1 replication and tran- scription and enhances the LTR-driven expression of inte- grated virus ...was 1 to 2 logs lower than the levels of nef and ... See full document
9
Enhancing the Proteolytic Maturation of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins
... was required for processing to be complete ...gp120- specific MAb, B12, it was clear that plasmin also digests gp120 into fragments, one of which is about 70 kDa ... See full document
11
Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum
... the protein turnover ...of Vpu, our data also revealed that CD4 KRcyto was still susceptible to Vpu- mediated CD4 ...strictly required for Vpu- mediated CD4 degradation and, therefore, ... See full document
15
The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.
... The Vpu-stimulated degradation in the ER is highly specific for CD4, requires the presence of the CD4 cytoplasmic tail (7, 21, 35, 36–38), and involves a physical interaction between Vpu and CD4 ... See full document
11
Functional Interaction of Human Immunodeficiency Virus Type 1 Vpu and Gag with a Novel Member of the Tetratricopeptide Repeat Protein Family
... pal virus receptor on T cells has provided a basic paradigm for virus entry ...facilitate protein folding (18). Cyclophilins A, B, and C interact with HIV-1 Gag, and cyclo- philin A is ... See full document
11
Regulation of Virus Release by the Macrophage-Tropic Human Immunodeficiency Virus Type 1 AD8 Isolate Is Redundant and Can Be Controlled by either Vpu or Env
... enhance virus secretion is apparent only after overexpression of the ...that Vpu and AD8 Env function through similar biochemical mechanisms, it can be speculated that such activity of the AD8 Env is ... See full document
10
Modulation of β-Catenin and E-Cadherin Interaction by Vpu Increases Human Immunodeficiency Virus Type 1 Particle Release
... of Vpu, which is consistent with a reduced turnover of  ...that Vpu-mediated stabili- zation of  -catenin results in enhanced TCF activity ...is required to determine how phosphorylated  -catenin ... See full document
7
Sustained Induction of NF-κB Is Required for Efficient Expression of Latent Human Immunodeficiency Virus Type 1
... for 1 or 6 h. Total RNA was extracted and initiated, and elongated HIV-1 mRNA transcripts were quantitated by real-time ...both 1 and 6 h after TNF- ␣ stimulation, whereas accumulation of elongated ... See full document
14
The envelope glycoprotein of human immunodeficiency virus type 2 enhances viral particle release: a Vpu-like factor?
... only human immunodeficiency virus type 1 (HIV-1) encodes the Vpu accessory protein (10, 32, 50), except for the chimpanzee simian immunodeficiency ... See full document
10
Human Immunodeficiency Virus Type 1 Vpu Protein Interacts with CD74 and Modulates Major Histocompatibility Complex Class II Presentation
... of Vpu is to increase the synthesis and release of new virions ...membrane. Vpu is also a cation-selective ion channel (13), and its interaction with the TASK-1 K ⫹ channel was shown to ... See full document
10
Antagonism of CD317 Restriction of Human Immunodeficiency Virus Type 1 (HIV-1) Particle Release and Depletion of CD317 Are Separable Activities of HIV-1 Vpu
... of Vpu to reduce cell surface exposure of WT and mutant CD317 ...stomatitis virus (VSV) G-protein-pseudotyped WT or HIV-1 ⌬ vpu ...infectious virus titers produced from in- ... See full document
6
CD63 Is Not Required for Production of Infectious Human Immunodeficiency Virus Type 1 in Human Macrophages
... of human immunodeficiency virus type 1 (HIV-1) particles, a number of tetraspanins can be incorpo- rated into the viral membrane (6, 23, ...in virus release and/or ... See full document
11
Sequence-Specific Binding of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein to Short Oligonucleotides
... during virus matu- ration, when the dimeric genomic RNA undergoes a stabiliza- tion event (19, 22, 23, ...the protein at sites where its chaperone activity is required; conversely, the chaperone ac- ... See full document
8
Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity.
... sarcoma virus and murine leukemia virus (4, 42), in which virions containing inactive proteases package genomic RNA as efficiently as wild- type ...Gag protein as did the wild-type ... See full document
8
Differential Effects of Human Immunodeficiency Virus Type 1 Vpu on the Stability of BST-2/Tetherin
... when Vpu is expressed at high levels (3, 5, 7, 11, 17, 20, 23, 26, ...discrete protein bands of approxi- mately 29 kDa ...a protein with high- mannose-type carbohydrate modifications ...lane ... See full document
9
The I Domain Is Required for Efficient Plasma Membrane Binding of Human Immunodeficiency Virus Type 1 Pr55Gag
... virion maturation would separate the I domain from the N-terminal membrane-binding region of ...(23), release of MA from the constraints imposed by the I domain may facilitate membrane dissociation of a ... See full document
10
Enzymatically Active APOBEC3G Is Required for Efficient Inhibition of Human Immunodeficiency Virus Type 1
... APO3G required higher levels of the en- zymatically inactive protein, leading us to conclude that wt APO3G had stronger antiviral potential than its deaminase- defective counterpart ...of virus- ... See full document
8
Viral Protein U (Vpu)-Mediated Enhancement of Human Immunodeficiency Virus Type 1 Particle Release Depends on the Rate of Cellular Proliferation
... the release of viral particles from the surface of infected cells ...of Vpu is dependent on cell type (2, 33); variations in the effect have been reported, with some investigators showing it to be ... See full document
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