[PDF] Top 20 Human Immunodeficiency Virus Type 1 Vpr Protein Does Not Modulate Surface Expression of the CD4 Receptor
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Human Immunodeficiency Virus Type 1 Vpr Protein Does Not Modulate Surface Expression of the CD4 Receptor
... of Vpr in downmodulation of the CD4 ...different Vpr alleles to alter steady-state levels of surface ...different Vpr alleles from HIV-1 and SIV were analyzed and compared with ... See full document
6
Vpr Is Required for Efficient Nef Expression from Unintegrated Human Immunodeficiency Virus Type 1 DNA
... activated CD4 ⫹ T cells in vivo ...and expression, although recent reports sug- gest that transcription from nonintegrated HIV DNA appears to be a normal early step in HIV ...tegration-competent ... See full document
9
Human Immunodeficiency Virus Type 1 Nef-Induced CD4 Cell Surface Downregulation Is Inhibited by Ikarugamycin
... of CD4 do not block viral budding but rather prevent incorporation of the envelope protein into the newly formed particles and thereby render the particles ...reducing CD4 surface ...restoring ... See full document
5
Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Enhances Expression from Unintegrated HIV-1 DNA
... during human immu- nodeficiency virus type 1 (HIV-1) replication and may play a significant role in HIV-1 ...HIV-1 Vpr is a virion-associated accessory ... See full document
11
Interference to human immunodeficiency virus type 1 infection in the absence of downmodulation of the principal virus receptor, CD4.
... cell-free virus (Fig. 1 and 3; Table 1) or by cocultivation ...a virus mutant competent in binding but not fusion (31), nor UV- or heat-inactivated HIV-1, which retains the ability to ... See full document
11
Human Immunodeficiency Virus Type 1 Nef Protein Targets CD4 to the Multivesicular Body Pathway
... total CD4 levels (Fig. 3A and B) but not the reduction of surface CD4 upon expression of Nef ...cells, CD4 accumulated within large vesicles that were often decorated by the ESCRT-0 ... See full document
13
Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry
... these CD4 dimerization mutants on viral entry efficiency, we generated stable cell lines by transfecting A201, a human CD4 negative T cell line [14], with expression vectors encoding ... See full document
8
Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum
... the protein turnover ...of CD4 KRcyto and CD4 wt in presence of Vpu, our data also revealed that CD4 KRcyto was still susceptible to Vpu- mediated CD4 ...mediated CD4 degradation ... See full document
15
Infectious properties of human immunodeficiency virus type 1 mutants with distinct affinities for the CD4 receptor.
... T-cell-tropic human immunodeficiency virus type 1 (HIV-1) have lower affinities for CD4 than their laboratory-adapted derivatives, that this may partly result from tighter ... See full document
8
Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR.
... of CD4 is most probably the reason for the increased levels of virus binding and proviral DNA synthesis in Jurkat/PKRLS9 cells after HIV-1 ...the expression of another protein required ... See full document
8
Expression and Characterization of a Single-Chain Polypeptide Analogue of the Human Immunodeficiency Virus Type 1 gp120-CD4 Receptor Complex
... using protein standards ranging from ...soluble CD4 (rsCD4) (re- ferred to as soluble gp120-rsCD4 complexes) were also run under identical conditions for ... See full document
10
Mutations in the matrix protein of human immunodeficiency virus type 1 inhibit surface expression and virion incorporation of viral envelope glycoproteins in CD4+ T lymphocytes.
... the human immunodeficiency virus type 1 (HIV-1) MA protein were identified to be critical for the incorporation of viral Env proteins into HIV-1 virions from ... See full document
10
Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.
... To test whether the expression of the consensus Nef protein also correlated with a decrease in surface CD4 expression, the transduced HuT-78 and AKR1-G1 cells were stained for human or m[r] ... See full document
9
Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Functions as an Immediate-Early Protein during HIV-1 Infection
... and Vpr, induce apoptosis of HIV-infected cells in different systems (16, 23, 38, 43, ...virion-associated Vpr by itself can induce apopto- sis of HIV infected ...this Vpr-induced apoptosis occurs in ... See full document
9
Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect
... of human immunodeficiency virus type 1 (HIV-1), Vpr is a highly conserved regulatory protein of 96 residues (14 ...of Vpr has been determined and consists of ... See full document
8
Impairment of Human Immunodeficiency Virus Type 1 (HIV-1) Entry into Jurkat T Cells by Constitutive Expression of the HIV-1 Vpr Protein: Role of CD4 Down-Modulation
... The human immunodeficiency virus type 1 (HIV-1) Vpr accessory gene product is a small virion-associated protein (15 kDa) that localizes in the nucleus of infected ... See full document
5
Human Immunodeficiency Virus Type 1 Vpr Interacts with Antiapoptotic Mitochondrial Protein HAX-1
... or virus-infected cells ...cell surface trigger receptor-activa- tion of caspases leading to mitochondrial membrane perme- abilization (MMP) (6, 18, ...including human immunodeficiency ... See full document
12
CD4-Chemokine Receptor Hybrids in Human Immunodeficiency Virus Type 1 Infection
... with CD4-CXCR4 ...wild-type receptor, CD4 (2D)CXCR4, and ...via CD4(4D)CXCR4 showed significantly greater sensitivity to AMD3100, which could not be attributed to any detectable ... See full document
14
Transdominant Activity of Human Immunodeficiency Virus Type 1 Vpr with a Mutation at Residue R73
... FIG. 1. Transcriptional activity of Vpr and its mutant ...wild-type Vpr depicting the areas representing helical domains I and II and the leucine-rich ...R73A) Vpr upon the HIV-1 ... See full document
5
Effect of human immunodeficiency virus type 1 protein R (vpr) gene expression on basic cellular function of fission yeast Schizosaccharomyces pombe.
... the vpr gene in S. pombe cells. The pREP1N- vpr plasmid was transformed into the wild-type SP223 ...gene expression was re- pressed) and without thiamine (vpr gene was constitutively ... See full document
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