[PDF] Top 20 Identification of a herpes simplex virus function that represses late gene expression from parental viral genomes.
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Identification of a herpes simplex virus function that represses late gene expression from parental viral genomes.
... The process of viral DNA replication influences the primary sites of initiation for the mRNAs transcribed from the simian virus 40 early transcription unit 5, 12, 16 and from the gene en[r] ... See full document
9
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.
... induce expression of ICP4 and other genes, are ...Epstein-Barr virus latency is maintained by at least two different strategies: blockade of signal transduction by a viral protein and negative ... See full document
7
Functional inaccessibility of quiescent herpes simplex virus genomes
... the viral gene expression program subsequent to the immediate-early phase ...Therefore, expression of eGFP from the HCMV IE pro- moter does not necessarily imply productive infection ... See full document
14
Transient Expression of Herpes Simplex Virus Type 1 ICP22 Represses Viral Promoter Activity and Complements the Replication of an ICP22 Null Virus
... five herpes simplex virus type 1 immediate early (IE) proteins, the least is known about the function of ICP22 during productive infection and ...expressed from its own promoter in the ... See full document
11
The Polyserine Tract of Herpes Simplex Virus ICP4 Is Required for Normal Viral Gene Expression and Growth in Murine Trigeminal Ganglia
... Herpes simplex virus type 1 (HSV-1), a member of the Al- phaherpesvirinae, is recognized by its rapid lytic growth char- acteristics, variable host range, and propensity to establish and reactivate ... See full document
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Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival
... activate gene expression without significantly affecting host cell ...ICP0 expression can result in the alteration in the expression of a subset of cellular genes (23) under conditions where ... See full document
13
The Initiator Element in a Herpes Simplex Virus Type 1 Late-Gene Promoter Enhances Activation by ICP4, Resulting in Abundant Late-Gene Expression
... during viral infection. The two important features of late genes that are in part functions of the activities of their promoters are their require- ment for DNA synthesis and their abundant ... See full document
11
Identification of an ICP27-Responsive Element in the Coding Region of a Herpes Simplex Virus Type 1 Late Gene
... gC expression by immunoblotting (Fig. 4C). As is shown, ICP27 expression was readily apparent for the WT protein and all mutants tested, except ...verified expression of most of the mutant ICP27 ... See full document
12
Identification of Sequences in Herpes Simplex Virus Type 1 ICP22 That Influence RNA Polymerase II Modification and Viral Late Gene Expression
... requires UL13 but Ser2P Pol II loss does not (23). Our tran- sient-expression analysis (Fig. 1D) showed that the PS mutant is the only one that is incapable of triggering loss of Ser-2P Pol II in transfected ... See full document
12
The N Terminus and C Terminus of Herpes Simplex Virus 1 ICP4 Cooperate To Activate Viral Gene Expression
... transcription from most viral ...whereas late genes are poorly activated, and virus growth is severely ...support viral replication and to regulate gene ...and viral ... See full document
13
Epigenetic Modulation of Gene Expression from Quiescent Herpes Simplex Virus Genomes
... of herpes simplex virus to persist in cells depends on the extent of viral-gene expression, which may be controlled by epigenetic ...the viral mutants d109 and d106 to ... See full document
11
Uncoupling Uncoating of Herpes Simplex Virus Genomes from Their Nuclear Import and Gene Expression
... the viral envelopes with host cell membranes, and the microtubule- motor dynein transports those incoming capsids to the nucleus (20, 47, 48, ...the viral envelope or are released into the cytosol, while ... See full document
13
Gamma Interferon Can Block Herpes Simplex Virus Type 1 Reactivation from Latency, Even in the Presence of Late Gene Expression
... Herpes simplex virus type 1 (HSV-1)-specific CD8 ⴙ T cells and the cytokine gamma interferon (IFN- ␥ ) are persistently present in trigeminal ganglia (TG) harboring latent ...functional viral ... See full document
9
Induction of Cellular Stress Overcomes the Requirement of Herpes Simplex Virus Type 1 for Immediate-Early Protein ICP0 and Reactivates Expression from Quiescent Viral Genomes
... the viral genome insensitive to treatments, such as provision of VP16, that are able to activate gene expression if provided at the time of infection, indicating that cellular silencing mechanisms ... See full document
9
Identification and Characterization of a Herpes Simplex Virus Gene Product Required for Encapsidation of Virus DNA
... In this study, we report the characterization of an HSV-1 mutant that has a temperature-sensitive processing defect in the nucleocapsid structural polypeptide p40 and fails to encapsidat[r] ... See full document
9
Unusual regulation of expression of the herpes simplex virus DNA polymerase gene.
... 7A, at 9 h in KOS-infected cells in the absence of drug, there were similar pol and tk primer extension signals, whereas in the presence KOS +KIAA RNA _ Early Late 0.34 0.44 0.072 0.57 C[r] ... See full document
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Expression of a cellular gene cloned in herpes simplex virus: rabbit beta-globin is regulated as an early viral gene in infected fibroblasts.
... 2368 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We constructed nondefective herpes simplex virus type 1 recombinants bearing the intact rabbit beta-globin inserted[r] ... See full document
10
UL31 of Herpes Simplex Virus 1 Is Necessary for Optimal NF-κB Activation and Expression of Viral Gene Products
... proteins from each sample at each time point were separated by SDS-PAGE, transferred to nitrocellulose membranes, and reacted with antibody for I B ␣ (the NF- B repressor), total JNK, and p-JNK as described in ... See full document
7
The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores
... their genomes into the nucleus, as evidenced by the predominance of empty capsids docked at NPCs ...result from breakdown of the HSV capsid since the capsid remains intact on the cytoplasmic side of the ... See full document
16
Mutations in the major DNA-binding protein gene of herpes simplex virus type 1 result in increased levels of viral gene expression.
... We have found that at the nonpermissive temperature, the synthesis of certain immediate early, early, and late viral polypeptides was greater in cells infected with the temperature-sensi[r] ... See full document
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