[PDF] Top 20 Identification of the Human Herpesvirus 6A gQ1 Domain Essential for Its Functional Conformation
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Identification of the Human Herpesvirus 6A gQ1 Domain Essential for Its Functional Conformation
... for its recognition by Mab AgQ ...U1102 gQ1 might contain an epitope for Mab AgQ ...the gQ1 amino acid se- quence of HHV-6A U1102 and HHV-6B strain HST, because the Mab recognized ... See full document
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Identification of Functional Domains in Kaposica, the Complement Control Protein Homolog of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8)
... host, identification of its structural determinants important in its function would not only help in elucidating the complement regulatory mechanisms of kaposica, but would also lead to the ... See full document
7
Determinants of Human CD134 Essential for Entry of Human Herpesvirus 6B
... 1 Identification of two amino acid residues within CD134 that are required for HHV-6B ligand ...of human and murine ...and its ligand (PBD accession number ... See full document
5
V Domain of Human SLAM (CDw150) Is Essential for Its Function as a Measles Virus Receptor
... 36. Takada, A., C. Robinson, H. Goto, A. Sanchez, K. G. Murti, M. A. Whitt, and Y. Kawaoka. 1997. A system for functional analysis of Ebola virus glycopro- tein. Proc. Natl. Acad. Sci. USA 94:14764–14769. 37. ... See full document
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Characterization of the Human Herpesvirus 6 U69 Gene Product and Identification of Its Nuclear Localization Signal
... 5B, part b), suggesting that the bipartite-type NLS sequence (amino acids 21 to 39) of U69 is a functional signal for nuclear translocation. To exclude completely the possibility that the GST-GFP fusion protein ... See full document
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The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity
... ABSTRACT Human herpesvirus 6A (HHV-6A) glycoprotein B (gB) is a glycoprotein consisting of 830 amino acids and is essential for the growth of the ...identified its epitope residue ... See full document
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Functional Identification and Analysis ofcis-Acting Sequences Which Mediate Genome Cleavage and Packaging in Human Herpesvirus 6
... consensus herpesvirus cleavage-packaging signals, pac1 and pac2, are located at the left and right genomic termini of human herpesvirus 6 (HHV-6), ...of human telomeric repeat sequences ... See full document
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The Herpesvirus Transactivator VP16 Mimics a Human Basic Domain Leucine Zipper Protein, Luman, in Its Interaction with HCF
... first human ligand for HCF ...activation domain and a common mech- anism for binding HCF. We found that Luman, its homolog in Drosophila, dCREB-A (also known as BBF-2), and VP16 bind to HCF by a ... See full document
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Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene.
... oncogenic herpesvirus saimiri protects cells from heterologous virus-induced ...homology domain, suggesting that this region is not essential for anti-apoptotic ...a functional bcl-2 homolog ... See full document
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Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction
... Confocal microscopy indicates that both Bet and feA3Z2b are apparently uniformly distributed in the cytoplasm and thus do not allow detection of protein relocalization upon complex formation. In contrast, feA3Z2a, which ... See full document
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Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction
... Confocal microscopy indicates that both Bet and feA3Z2b are apparently uniformly distributed in the cytoplasm and thus do not allow detection of protein relocalization upon complex formation. In contrast, feA3Z2a, which ... See full document
20
Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication
... also essential for viral lytic ...from its antiapo- ptotic and antiautophagic ...BH4 domain but is not involved in the formation of the central hydrophobic BH3-pep- tide binding groove, which ... See full document
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Human Herpesvirus 6B Genome Sequence: Coding Content and Comparison with Human Herpesvirus 6A
... 1999 Human herpesvirus 6 variants A and B (HHV-6A and HHV-6B) are closely related viruses that can be readily distinguished by comparison of restriction endonuclease profiles and nucleotide ... See full document
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Crystal Structure of the DNA-Binding Domain of Human Herpesvirus 6A Immediate Early Protein 2
... IMPORTANCE Human herpesvirus 6A (HHV-6A) and HHV-6B belong to betaherpesvi- rus ...DNA-binding domain shared with other betaherpesviruses such as human herpesvirus 7 and ... See full document
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Human Herpesvirus 6A U14 Is Important for Virus Maturation
... (10 5.30 versus 10 4.01 , respectively) (Fig. 2A), the increase per initial virus genome was low (10 0.68 versus 10 1.24 compared with the wild type and 10 0.68 versus 10 1.60 compared with the revertant) (Fig. 2B). ... See full document
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Human Herpesvirus 6 Glycoprotein Complex Formation Is Required for Folding and Trafficking of the gH/gL/gQ1/gQ2 Complex and Its Cellular Receptor Binding
... complex, and the complex was transported to the cell surface in our transient-expression system. In HCMV, the level of export of gH/gL complexes from the ER to the Golgi apparatus and cell surface is dramatically ... See full document
10
A Human Herpesvirus 6A-Encoded MicroRNA: Role in Viral Lytic Replication
... The HHV-6A orthologue of the HCMV IE2 protein is encoded by a spliced transcript originating from ORFs U90 and U86 (31). HHV-6A miR-U86 is expressed from the opposite strand of the U86 ORF, and as a result ... See full document
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Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2−/−γc−/− Mice
... serious human diseases have been correlated with human herpesvirus 6A (HHV-6A) and HHV-6B, the lack of animal models has prevented studies which would more definitively link these viral ... See full document
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Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration
... are essential for integration; however, the protein factors mediating integration remain ...not essential for telomere integration; thus, we set out to assess the contribution of potential viral ... See full document
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Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration
... telomeric G-quadruplexes was confirmed by surface plasmon resonance, while circular dichroism spectra coupled with melting analyses indicated that BRACO-19 stabilizes the G-quadruplex structure. Considering that HR is a ... See full document
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