[PDF] Top 20 Identification of a Lytic-Cycle Epstein-Barr Virus Gene Product That Can Regulate PKR Activation
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Identification of a Lytic-Cycle Epstein-Barr Virus Gene Product That Can Regulate PKR Activation
... The Epstein-Barr virus (EBV) SM protein is a posttranscriptional regulator of viral gene ...simplex virus type 1 (HSV-1) ICP27 gene product, the first member of this class ... See full document
9
Cellular STAT3 Functions via PCBP2 To Restrain Epstein-Barr Virus Lytic Activation in B Lymphocytes
... to regulate susceptibility of EBV-infected B cells to lytic activation ...the gene(s) transcriptionally ac- tivated by STAT3 in refractory compared to lytic ...STAT3 can ... See full document
10
Role of the Epstein-Barr Virus Rta Protein in Activation of Distinct Classes of Viral Lytic Cycle Genes
... to activation by Rta in a transient reporter assay in Raji ...endogenous virus in HH514-16 cells but also efficiently activates an RpCAT reporter in these cells ...the activation of a late ... See full document
9
The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes
... Rp activation in one of several ...EBV gene might induce or modify one or more cellular proteins enabling it to bind to Rp by an indirect ...or lytic EBV gene product that is induced by ... See full document
7
ZEB Negatively Regulates the Lytic-Switch BZLF1 Gene Promoter of Epstein-Barr Virus
... Epstein-Barr virus (EBV) is a human herpesvirus capable of establishing a latent state in B ...The product of the immediate-early BZLF1 gene, Zta, is a transcriptional transactivator ... See full document
9
Cell Cycle Analysis of Epstein-Barr Virus-Infected Cells following Treatment with Lytic Cycle-Inducing Agents
... life cycle (16, 17). The latency-type gene expression patterns are associated with cell proliferation, and many of these genes function, in part, to activate cell cycle pathways leading to cell ... See full document
8
Identification and Characterization of the Physiological Gene Targets of the Essential Lytic Replicative Epstein-Barr Virus SM Protein
... Epstein-Barr virus (EBV) SM protein is an essential lytic cycle protein with multiple posttranscriptional mechanisms of ...several lytic cycle mRNAs and proteins at ... See full document
16
A Redox-Sensitive Cysteine in Zta Is Required for Epstein-Barr Virus Lytic Cycle DNA Replication
... of lytic cycle gene expression and DNA replication. Zta can be sumoylated on lysine 12, and mutation of lysine 12 to alanine causes a severe defect in lytic cycle DNA replication ... See full document
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Identification of a Negative cis Element within the ZII Domain of the Epstein-Barr Virus Lytic Switch BZLF1 Gene Promoter
... viral lytic cycle (7, 11, 19, 44, ...and activation by lytic cycle-inducing agents (11, ...BZLF1 gene product Zta ...BZLF1 gene appears to involve two steps: (i) ... See full document
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Identification of a Novel Element Involved in Regulation of the Lytic Switch BZLF1 Gene Promoter of Epstein-Barr Virus
... the product of the increases due to the mutation and inducers alone ...modest activation of transcription of the BZLF1 promoter through signal trans- duction pathways affecting the activities of some of the ... See full document
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Protein Kinase C-Independent Activation of the Epstein-Barr Virus Lytic Cycle
... for activation of latent Epstein- Barr virus (EBV) into the lytic ...EBV lytic replication. Zp, the promoter of the EBV immediate-early gene BZLF1, whose product, ... See full document
15
Activators of the Epstein-Barr Virus Lytic Program Concomitantly Induce Apoptosis, but Lytic Gene Expression Protects from Cell Death
... the lytic program; this antigen is expressed at the cell ...that lytic EBV gene expression blocks or very significantly delays apoptosis in BL ... See full document
11
An Epigenetic Journey: Epstein-Barr Virus Transcribes Chromatinized and Subsequently Unchromatinized Templates during Its Lytic Cycle
... late lytic phases, followed by enrichment for EU-labeled RNAs and RNA-seq to assay for viral and cellular genes that are being actively transcribed at different times during the lytic ...late gene ... See full document
13
Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production
... knockout virus by an exogenous supply of ...viral lytic proteins (BZLF1, BALF2, BMRF1, BALF4, and BRRF2) were expressed at almost equal levels in the knockout virus compared to wild type ... See full document
18
Signal Transducer and Activator of Transcription 3 Limits Epstein-Barr Virus Lytic Activation in B Lymphocytes
... late lytic protein) protein levels in AG490-treated LCL derived from two AD-HIES patients with different mutations in the STAT3 DNA-binding domain, the levels of ZEBRA remained relatively unchanged before and ... See full document
9
Induction of the Early Growth Response 1 Gene by Epstein-Barr Virus Lytic Transactivator Zta
... Zta can activate its target promoters through direct binding to DNA sequences which match or slightly deviate from the ZRE consensus (20, 21, 35, ...Zta-induced activation of the Egr-1 ... See full document
8
The Epstein-Barr Virus BDLF4 Gene Is Required for Efficient Expression of Viral Late Lytic Genes
... revertant virus were generated using a BAC system in Escherichia coli (25, ...BDLF4 gene at residue 74 and creation of a new termination signal after synthesizing 12 nonsense, unrelated amino ac- ... See full document
5
Epstein-Barr Virus BALF3 Has Nuclease Activity and Mediates Mature Virion Production during the Lytic Cycle
... the lytic cycle, knock- down of BALF3 was achieved with a ...the lytic cycle, resulting in the suppression of BALF3 expression in a con- centration-dependent manner ...other lytic ... See full document
14
Valproic Acid Antagonizes the Capacity of Other Histone Deacetylase Inhibitors To Activate the Epstein-Barr Virus Lytic Cycle
... separate gene expression microarray experiments were ...University. Gene expression data were pro- cessed using the Robust Multi-Array Average method (11), and quantile nor- malization was performed using ... See full document
16
Induction of the Lytic Cycle Sensitizes Epstein-Barr Virus-Infected B Cells to NK Cell Killing That Is Counteracted by Virus-Mediated NK Cell Evasion Mechanisms in the Late Lytic Cycle
... the lytic cycle (19), had effects similar to those seen in 293 cells, in that ULBP expression significantly increased ...late-stage lytic cycle are protected from NK cell ...the lytic ... See full document
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