[PDF] Top 20 Identification of nuclear and nucleolar localization signals in the herpes simplex virus regulatory protein ICP27.
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Identification of nuclear and nucleolar localization signals in the herpes simplex virus regulatory protein ICP27.
... these signals: the sequences are extremely rich in basic amino acids, in particular arginine residues, and they contain a functional ...the nucleolar localiza- tion of several cellular proteins does not ... See full document
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Identification of Nuclear and Nucleolar Localization Signals of Pseudorabies Virus (PRV) Early Protein UL54 Reveals that Its Nuclear Targeting Is Required for Efficient Production of PRV
... the nuclear targeting of UL54 was demonstrated to be required for effi- cient viral DNA replication, viral mRNA accumulation, and protein ...nucleolus. Nucleolar targeting of herpesvirus saimiri ... See full document
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Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58)
... specialized nuclear compartment, the nucleolus, which is a highly organized and dynamic non-membrane-bound subcompartment of the ...multiple protein-protein and protein-nucleic acid inter- ... See full document
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Identification and Characterization of Nuclear and Nucleolar Localization Signals in the Adeno-Associated Virus Serotype 2 Assembly-Activating Protein
... mediates nuclear local- ization in the absence of the other (41, 42); the nonstructural protein 1 of influenza A virus (NS1A) has a functionally compe- tent monopartite NLS, DRLRRDQKSLR, and a ... See full document
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Mapping of Functional Regions in the Amino-Terminal Portion of the Herpes Simplex Virus ICP27 Regulatory Protein: Importance of the Leucine-Rich Nuclear Export Signal and RGG Box RNA-Binding Domain
... HSV-1 ICP27 NES deletion ...an ICP27 null mutant ...of ICP27 which completely eliminate virus growth when deleted or altered (24, 33, 34, ...of ICP27, since dLeu shows an approximately ... See full document
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The Conserved Carboxyl-Terminal Half of Herpes Simplex Virus Type 1 Regulatory Protein ICP27 Is Dispensable for Viral Growth in the Presence of Compensatory Mutations
... the ICP27-re- lated proteins expressed by the various ...Total protein samples were prepared from infected cells at 6 hpi and analyzed by immunoblotting using the H1113 antibody ...major ... See full document
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Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4.
... by herpes simplex virus (HSV) and activates transcription of viral genes during subsequent phases of productive ...encode regulatory proteins that have extensive homology with ICP4 and exhibit ... See full document
9
Overexpression of the herpes simplex virus type 1 immediate-early regulatory protein, ICP27, is responsible for the aberrant localization of ICP0 and mutant forms of ICP4 in ICP4 mutant virus-infected cells.
... that ICP27 is critical in determining the intracellular localization of ICP0 and certain mutant forms of ICP4 in ICP4 mutant virus- infected ...which ICP27 affects the nuclear ... See full document
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Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.
... and ICP27 on the intracellular localization of ICP4 in transient expression ...assays, ICP27 or ICP0 was able to affect the localization of ICP4 in the absence of other HSV-specified gene ... See full document
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Identification of a Motif in the C Terminus of Herpes Simplex Virus Regulatory Protein ICP4 That Contributes to Activation of Transcription
... the identification of a motif in the C-terminal portion of ICP4 that contributes to activation but is not required for repression of viral gene pro- ...bility, nuclear localization, DNA binding ... See full document
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Herpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3' ends of labile mRNA.
... by ICP27 cotransfection (namely, intact unspliced IFN-b and the CAT ORF with either c-myc- or IFN- b gene-derived 3 9 regions) appears to provide a satis- fying targeting mechanism that can lead to enhanced ... See full document
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Signals That Dictate Nuclear, Nucleolar, and Cytoplasmic Shuttling of the γ134.5 Protein of Herpes Simplex Virus Type 1
... directing nuclear accumu- lation of GFP, the mutant 188-236 tends to concentrate in areas resembling the ...bipartite nuclear localization signals defined in nucleoplasmin and N1 from Xenopus ... See full document
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The herpes simplex virus type 1 regulatory protein ICP27 coimmunoprecipitates with anti-Sm antiserum, and the C terminus appears to be required for this interaction.
... the nuclear localization and nucleolar localization regions (24, ...of nuclear extracts from transfections with these mutants showed that the mutant ICP27 protein could be ... See full document
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Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression.
... amino-terminal localization region of ICP27 do not significantly affect viral DNA ...replication. ICP27 appears to have a role in viral DNA replication because ICP27 deletion mutants and some ... See full document
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Analysis of the Phosphorylation Sites of Herpes Simplex Virus Type 1 Regulatory Protein ICP27
... mutant ICP27 constructs, as indicated in Table 1, or with wild-type ICP27 or pGEM-1 vector ...an ICP27 deletion virus, ...27-del virus growth was arbitrarily set to an index value of 1. ... See full document
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Control of VP16 Translation by the Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27
... lacking ICP27. In order to deter- mine whether and how ICP27 modulates VP16 gene expres- sion, we undertook a series of experiments that carefully com- pared the levels of VP16 protein and mRNA in ... See full document
12
Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1
... are nuclear-replicating viruses that have successfully evolved to evade the immune system of humans, establish- ing lifelong ...infections. ICP27 from herpes simplex virus is a ... See full document
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Efficient Nuclear Export of Herpes Simplex Virus 1 Transcripts Requires both RNA Binding by ICP27 and ICP27 Interaction with TAP/NXF1
... FIG. 7. Microarray analysis of the cytoplasmic/nuclear ratio for HSV-1 transcripts. (A, B) HeLa cells were infected with wild-type (WT) HSV-1 KOS for 8 h. Cells were lysed, and nuclear and cytoplasmic ... See full document
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Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27.
... Analysis of the mutant phenotypes suggests that ICP27 has the following regulatory effects during the viral infection: i stimulation of expression of fy-1 genes, ii induction of expressi[r] ... See full document
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Identification of an ICP27-Responsive Element in the Coding Region of a Herpes Simplex Virus Type 1 Late Gene
... then ICP27’s appar- ent ability to enhance mRNA accumulation from the UL42-SE gene may simply reflect the disruption of the putative UL42 inhibitory ...the ICP27-inde- pendent expression of gC in a d27 ⌬ CA ... See full document
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