[PDF] Top 20 Human Immunodeficiency Virus Type 1 Nef Domains Required for Disruption of Major Histocompatibility Complex Class I Trafficking Are Also Necessary for Coprecipitation of Nef with HLA-A2
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Human Immunodeficiency Virus Type 1 Nef Domains Required for Disruption of Major Histocompatibility Complex Class I Trafficking Are Also Necessary for Coprecipitation of Nef with HLA-A2
... wild-type Nef reduced the amount of HLA-A2 transported to the cell surface in 1 h by three- to sixfold (from about 30% to 5%) ...total HLA-A2 was obtained in the control ... See full document
5
Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, Nef
... The human immunodeficiency virus type 1 (HIV-1) early gene nef is highly polymorphic (10, 25, 30, 38, ...the Nef gene product alters numerous pathways of T-cell ... See full document
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HIV-1 Nef Disrupts Intracellular Trafficking of Major Histocompatibility Complex Class I, CD4, CD8, and CD28 by Distinct Pathways That Share Common Elements
... The Nef protein is an important HIV virulence factor that promotes the degradation of host proteins to augment virus production and facilitate immune ...of Nef are major ... See full document
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Cooperative Binding of the Class I Major Histocompatibility Complex Cytoplasmic Domain and Human Immunodeficiency Virus Type 1 Nef to the Endosomal AP-1 Complex via Its μ Subunit
... endosomal trafficking, Nef may be viewed as a virally encoded CLASP ...AP complex family, extending the breadth and specificity of molecular sorting in the endo- somal ...herein, Nef ... See full document
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Human Immunodeficiency Virus Type 1 Nef Expression Prevents AP-2-Mediated Internalization of the Major Histocompatibility Complex Class II-Associated Invariant Chain
... are necessary for the internalization of mature MHC-II molecules ...transmembrane domains probably packed closely together (see reference ...of Nef-expressing cells appeared to be concentrated in ... See full document
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Nef-Mediated Disruption of HLA-A2 Transport to the Cell Surface in T Cells
... Human immunodeficiency virus type 1 (HIV-1) Nef is a key pathogenic factor necessary for the development of ...of Nef is to reduce cell surface levels of ... See full document
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Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2
... of major histocompatibility complex (MHC) class I molecules by Nef is thought to be an important immune evasion mechanism of human immunodeficiency virus ... See full document
8
Vpr Is Required for Efficient Nef Expression from Unintegrated Human Immunodeficiency Virus Type 1 DNA
... infectious virus by promoting budding and virion release (7, 31, ...of Nef may prevent superinfection and conserve virions for spread to uninfected ...to Nef. Nef protects infected cells from ... See full document
9
Direct Binding of Human Immunodeficiency Virus Type 1 Nef to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail Disrupts MHC-I Trafficking
... HIV-1 Nef in which Nef physically associates with MHC-I have ...HIV-1 Nef directly binds to the cytoplasmic domain of HLA-A2 in ...(A) Nef association with ... See full document
12
Modulation of Cellular Protein Trafficking by Human Immunodeficiency Virus Type 1 Nef: Role of the Acidic Residue in the ExxxLL Motif
... The nef gene of primate lentiviruses is required for high-level viremia and the efficient pathogenesis of AIDS (12, 25, ...of Nef on the cellular protein trafficking environment. Nef ... See full document
13
Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis
... The nef gene products encoded by human immunodeficiency virus type 1 (HIV-1) and simian immunodefi- ciency virus type 1 (SIV-1) increase viral ... See full document
10
Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Matrix
... of Nef to enhance the infec- tivity of HIV-1 virions produced either in CD4-negative ad- herent cells or in a T-cell ...that Nef targets HIV-1 budding to lipid rafts in transiently transfected ... See full document
6
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis.
... Does Nef act directly or indirectly? The infectivity of a virus expressing a nonmyristoylated form of the protein is as im- paired as that of a nef-deleted ...virus. Nef must therefore ... See full document
9
Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.
... No depletion of CD4+ human thymocytes was observed in implants infected with either HIV-lJRCSF or its nef mutant at 3 or 6 weeks postinfection compared with controls consisting of mock-i[r] ... See full document
8
Disulfide bond formation in the human immunodeficiency virus type 1 Nef protein.
... To evaluate the effect of wild-type and cysteine mutant ELI and LAI Nef proteins on virus replication, the CD4+ T-cell line Jurkat and primary peripheral blood mononuclear cells PBMCs we[r] ... See full document
5
Functional Characterization of the Human Immunodeficiency Virus Type 1 Nef Acidic Domain
... crucial Nef residue that has not been included in either the NPA or NMA model is ...wild- type levels ...of Nef that are important for MHC-I downregu- lation and CD4 downregulation are ... See full document
12
Predicting the Impact of Blocking Human Immunodeficiency Virus Type 1 Nef In Vivo
... We also considered two hypotheses about the impact of Nef on resting CD8 T-cell ...by Nef is not observed in dendritic cells (8, 31, 45, 52), no effect of Nef was assumed for naïve-cell ... See full document
8
Primary Human Immunodeficiency Virus Type 1 Nef Alleles Show Major Differences in Pathogenicity in Transgenic Mice
... HIV-1 nef alleles in in vitro ...disrupted nef gene (nef-) or the indicated nef alleles pseudotyped with the vesicular stomatitis virus G glycoprotein and analyzed by flow ... See full document
17
Different Effects of Nef-Mediated HLA Class I Down-Regulation on Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Cytolytic Activity and Cytokine Production
... (mutant Nef that fails to down-regulate HLA class I molecules but retains other Nef functions) ...of HLA-A24 and HLA-B35 on the infected CD4 ⫹ ... See full document
9
Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease.
... Virion-associated Nef is cleaved by PR. To examine whether Nef can be detected in mature HIV-1 virions, we constructed a nef-positive variant of the infectious molecular clone HXBH10, ... See full document
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