[PDF] Top 20 Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?
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Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?
... of MET gene amplification also in- cluding polysomies showed no association with MET pro- tein ...tween MET gene copy number and MET protein expres- sion ...of MET by IHC, west- ... See full document
12
Expression and prognostic relevance of MET and phospho-BAD in non-small cell lung cancer
... to MET receptor and undergoes phos- phorylation on intracellular tyrosine residues, leading to activation of some downstream signaling ...including cell proliferation, motility, angiogen- esis, and ... See full document
9
Targeting the MET receptor tyrosine kinase in non-small cell lung cancer: emerging role of tivantinib
... Abstract: MET receptor tyrosine kinase and its natural ligand, hepatocyte growth factor, have been implicated in a variety of cancers, including non-small cell lung cancer ...of ... See full document
8
Hsa_circ_0003998 promotes cell proliferation and invasion by targeting miR-326 in non-small cell lung cancer
... Notes: expression of hsa_circ_0003998 in four nsclc cells and one cultured human lung epithelial cell line ...relative expression levels of hsa_circ_0003998 were determined in 60 paired nsclc ... See full document
9
<p>Targeting the MET-Signaling Pathway in Non-Small–Cell Lung Cancer: Evidence to Date</p>
... of MET, in combination with fi rst-line platinum-based doublet chemotherapy, in patients with squa- mous cell ...IHC-detected MET, med- ian PFS lasted ...with non-squamous NSCLC (GO27281) did ... See full document
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MET expression and copy number heterogeneity in nonsquamous non-small cell lung cancer (nsNSCLC)
... with MET amplification. Those patients with a MET/CEP7 ratio of ≥ ...If MET status by FISH is less heterogeneous than MET IHC remains to be determined, as small numbers in our ... See full document
12
Elevated expression of podoplanin and its clinicopathological, prognostic, and therapeutic values in squamous non-small cell lung cancer
... PDPN expression on both the mRNA level and the protein level has a significant impact on clinicopathological features (pleural invasion, LVI, and lymph node involvement) along with patient survival in SqNSCLC by ... See full document
12
TIPE2 suppresses angiogenesis and non-small cell lung cancer (NSCLC) invasiveness via inhibiting Rac1 activation and VEGF expression
... Non-small cell lung cancer (NSCLC) is one of the leading causes of all cancer- related deaths ...the expression and roles of TIPE2 in ...the activation of Rac1 and ... See full document
16
<p>MET Oncogene in Non-Small Cell Lung Cancer: Mechanism of MET Dysregulation and Agents Targeting the HGF/c-Met Axis</p>
... with MET alterations, immu- notherapy can be administered after exhaustion of the tar- geted therapy and ...with MET alterations (MET ampli fi cation n=13, METex14 skipping mutation ...In MET ... See full document
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Association of integrin beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small cell lung cancer
... activates non receptor tyrosine kinases, FAK and Src, which play an important role in tumorigenesis by promoting the proliferation and invasion of cancer and endothelial cells ...the cell lines with ... See full document
8
High CEP55 expression is associated with poor prognosis in non-small-cell lung cancer
... minor changes. Tissue sections were deparaffinized with dimethylbenzene and then rehydrated through 100%, 95%, 90%, 80%, and 70% ethanol for 3 minutes each. After the PBS wash step, the slides were boiled for 15 minutes ... See full document
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Original Article Co-expression of delta-catenin and RhoA is significantly associated with a malignant lung cancer phenotype
... positive expression and RhoA over-expres- sion is consistently found in non-small cell lung cancer, but not in normal lung tissue, and that their co-expression was ... See full document
9
Expression of Derlin-1 and its effect on expression of autophagy marker genes under endoplasmic reticulum stress in lung cancer cells
... tumours. Cancer treatment can induce the endoplasmic reticulum (ER) stress response, and lead to misfolded or unfolded protein aggregation in the ER lumen and intracellular Ca 2+ balance ... See full document
5
FDG PET in the evaluation of response to nivolumab in recurrent non small cell lung cancer
... 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) is an effective tool for assessing treatment response and surveillance of disease recurrence; however, it sometimes shows increased FDG uptake at sites of ... See full document
5
Tobacco smoking and cessation and PD-L1 inhibitors in non-small cell lung cancer (NSCLC): a review of the literature
... Because of low level of evidence, abstracts only, book chapters, errata, editorial comments and letters to the editor were not included. Consequently, six papers (published as abstracts only) were excluded. Further- ... See full document
6
Original Article PI3K expression predicts overall survival in lung adenocarcinoma
... in non-small cell lung cancer (NSCLC) remains contro- ...normal lung tis- sue ...PI3K/p-PI3K expression in lung cancer tissue differed significantly from ... See full document
10
MiR-195 suppresses non-small cell lung cancer by targeting CHEK1
... including non-small cell lung cancer ...of non-smoking women with lung ...miR-195 expression was lower in tumor tissues and was associated with poor survival ... See full document
12
Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer
... of lung and other cancers. Recent progress in the treatment of lung cancer with im- mune therapies reinforces the need to better understand host immune responses in the context of lung ...a ... See full document
5
Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms
... All clinical data (age, sex, first diagnosis, follow- up, date of death, and OS) were selected from the patients records and supplemented by the local tumor registry from the Tumorcenter, Erfurt, Germany. Additionally, ... See full document
13
Downregulation of VEGF and KSP Gene Expression Inhibits Proliferation of A549 Cells
... and transfected with siRNA and then we need to change the medium six hours after transfection. At 24, 48 and 72 h post-transfection, MTT (5 mg/ml) was added to the cells, which were incubated at 37˚C for ... See full document
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