[PDF] Top 20 Incomplete transformation of rat cells by a deletion mutant of adenovirus type 5.
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Incomplete transformation of rat cells by a deletion mutant of adenovirus type 5.
... Although foci of transformed cells appeared in 3Y1 cells infected with both dl313 and Ad5 wild type, some differences were observed between cells transformed by d1313 and Ad5 wild type..[r] ... See full document
7
Mutant adenovirus type 9 E4 ORF1 genes define three protein regions required for transformation of CREF cells.
... the mutant 9ORF1 proteins exhibit decreased tumorigenic growth in ...CREF cells expressing wild-type 9ORF1 elicit significantly larger tumors in animals than do control CREF cells ...cellular ... See full document
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Transformation of rat cells by cyt mutants of adenovirus type 12 and mutants of adenovirus type 5.
... Transformation of rat kidney cells by an Ad5 host range group 1I mutant and deletion mutants at different multiplicities of infection.. The defect in transformation appears to be heterog[r] ... See full document
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Induction of Transformation and p53-Dependent Apoptosis by Adenovirus Type 5 E4orf6/7 cDNA
... two deletion endpoints (Fig. 1). Four deletion mutants, dl9/115, dl9/274, dl285/451, and dl309/451, were con- structed by PCR, using primer pairs E4dl9/115fw (5⬘-GCC GAA TTC AAT ATG ACT ACG GCT ACC ... See full document
9
Reduced Infectivity of Adenovirus Type 5 Particles and Degradation of Entering Viral Genomes Associated with Incomplete Processing of the Preterminal Protein
... Hr6-infected cells was the absence of the E1B ...null mutant (AdEasyE1⌬2347) engineered to carry only the Hr6 mutation that prevents the production of the E1B 55-kDa protein (deletion of bp 2347) ... See full document
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E4orf1 Limits the Oncolytic Potential of the E1B-55K Deletion Mutant Adenovirus
... cullin 5 (Cul5), elongins B and C, and Rbx1 (39, ...the adenovirus ubiquitin ligase are central to the cellular response to DNA ...in cells infected with the E1B-55K mutant may stem from a ... See full document
11
Reduced microfilament organization in adenovirus type 5-infected rat embryo cells: a function of early region 1a.
... Mutants defective in Ad5 early genes were used to show that reduced microfilament organization was a function of the Ad5 transformation early gene la Ela and did not require expression o[r] ... See full document
7
Adenovirus Type 5 Early Region 1B 55K Oncoprotein-Dependent Degradation of Cellular Factor Daxx Is Required for Efficient Transformation of Primary Rodent Cells
... and mutant variants E1B-55K-KK (pE1B-KK; ...H1299 cells, together with human p53 ...the cells examined (n ⬎ 50; ...the cells (n ⬎ 50), localization of E1B-KK mutant protein was slightly ... See full document
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Transformation-defective mutant of adenovirus type 5 containing a single altered E1a mRNA species.
... a U tigations of mutants containing alterations in this region have shown that these products are required directly or indirectly for the transformation of rat embryo cells, for the repl[r] ... See full document
8
Deletion and insertion mutations in early region 1a of type 5 adenovirus that produce cold-sensitive or defective phenotypes for transformation.
... Transforming activity in CREF cells of hybrid plasmids containing Ela or Ela and Elb gene sequences of dIlOl, hrl, and sub3O9 Foci per plate viral DNA Cloned Cloned viral DNA Plasmid clo[r] ... See full document
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In vitro synthesis of adenovirus type 5 T antigens. II. Translation of virus-specific RNA from cells transformed by fragments of adenovirus type 5 DNA.
... In the accompanying paper 9, we have shown that in lytically infected cells the transforming region of Ad5 is transcribed into RNAs that can be translated in vitro into proteins with app[r] ... See full document
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Microtubule-Mediated and Microtubule-Independent Transport of Adenovirus Type 5 in HEK293 Cells
... Fig. 5 and in Tables 1 and 2 do not support an essential role for microtubules in successful ge- nome delivery in either 293 or A549 ...some cells in the popula- tion, it seems unlikely to compensate for ... See full document
10
Induced expression of the endogenous beta interferon gene in adenovirus type 5-transformed rat fibroblasts.
... Evidence that Ad5-transformed cells which express high levels of ISG15 mRNA show a reduced capacity to proliferate in soft Approximately 5 x 103 or 5 x 104 cells from each of the cell li[r] ... See full document
7
Interaction of Adenovirus Type 5 Fiber with the Coxsackievirus and Adenovirus Receptor Activates Inflammatory Response in Human Respiratory Cells
... bacterial cells were collected by ...bacterial cells as a soluble protein was performed as previously described with minor modification ...bacterial cells were incubated with lysozyme and nonionic ... See full document
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Transformation-deficient adenovirus mutant defective in expression of region 1A but not region 1B.
... Viral 106 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest An adenovirus type 5 host range mutant hr440 has been isolated which is defective in a splicing event required[r] ... See full document
8
Biochemical studies on bovine adenovirus type 3. II. Incomplete virus.
... The fact that viral DNA was synthesized in CKT1 cells infected with purified incomplete virus clearly indicates that incomplete virus can express early functions necessary for replicatio[r] ... See full document
8
Transformation of rodent cells by DNA extracted from transformation-defective adenovirus mutants.
... GRAHAM Departments of Pathology and Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1 Complementation group II host range mutants of adenovirus type 5 which map in early re[r] ... See full document
6
Characterization of a temperature-sensitive mutant of human adenovirus type 7.
... To determine if the viral polypeptides were assembled into capsomeres, cytoplasmic extracts of WT- and mutant-infected cells labeled with [35S]methionine were analyzed on sucrose gradien[r] ... See full document
11
Adenovirus types 2 and 5 functions elicit replication and late expression of adenovirus type 12 DNA in hamster cells.
... In the Adl2-infected transformed cell lines, all or at least most of the Adl2-specific late functions, expressed as mRNA in Adl2 productively infected human cells, appear to be expressed[r] ... See full document
9
Characterization of a Temperature-Sensitive Fiber Mutant of Type 5 Adenovirus and Effect of the Mutation on Virion Assembly
... 6A, radioactivity was detected in particles having the electron microscopic appearance and the buoyant density of empty capsids p 1.29 g/ml and complete virions p 1.33 g/ml 30, 40.. The [r] ... See full document
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