[PDF] Top 20 Induction of T-Cell Immunity to Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
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Induction of T-Cell Immunity to Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... cohort. Human Research Ethics approval was granted to conduct this ...ARV drug-resistant HIV-1 likely to be capable of generating T-cell responses to HIV were ...more ... See full document
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Induction of Potent Human Immunodeficiency Virus Type 1-Specific T-Cell-Restricted Immunity by Genetically Modified Dendritic Cells
... the induction of HIV-1-specific T-cell immunity, because an effective control of HIV-1 and SIV has been induced only by replication-com- petent (wild-type or attenuated) ... See full document
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Naïve T-Cell Dynamics in Human Immunodeficiency Virus Type 1 Infection: Effects of Highly Active Antiretroviral Therapy Provide Insights into the Mechanisms of Naïve T-Cell Depletion
... purified cell subsets were quantitated by real-time PCR by the cell lysis method as described previ- ously ...the cell lysate was checked by real-time PCR using a ribosomal protein gene and a TaqMan ... See full document
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Induction of Bcl-xL Expression by Human T-Cell Leukemia Virus Type 1 Tax through NF-κB in Apoptosis-Resistant T-Cell Transfectants with Tax
... of T-cell receptor ␣ promoter, 5⬘-cgatCCATGACGTCATGGat-3⬘ and 3⬘-taGGTACTG ...for 1 h on ice prior to incubation with radiolabeled probes in ... See full document
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Antiretroviral Therapy Restores Diversity in the T-Cell Receptor Vβ Repertoire of CD4 T-Cell Subpopulations among Human Immunodeficiency Virus Type 1-Infected Children and Adolescents
... Human immunodeficiency virus (HIV) type 1 infection perturbs the T-cell receptor (TCR) V  ...CD4 T cells to assess the impact of the virus on clonality ... See full document
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Multiple T-Cell Responses to Human Immunodeficiency Virus Type 1 Are Enhanced by Dendritic Cells
... to T cells (2). Indeed, it is likely that during HIV-1 infection, DC are required to take up, process, and present HIV-1 antigens via their major histocompatibility com- plex (MHC) class I and II ... See full document
14
Human Immunodeficiency Virus Type 1 Cloning Vectors for Antiretroviral Resistance Testing
... Human immunodeficiency virus type 1 (HIV-1) gene muta- tions conferring resistance to reverse transcriptase (RT) and protease (PR) inhibitors may lead to virologic failure of the ... See full document
9
Gag Determinants of Fitness and Drug Susceptibility in Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1
... (patient 1) was identified who had experienced exten- sive antiretroviral ...patient 1 had been treated with four PI (indinavir [IDV], lopinavir [LPV], ritonavir, and saquinavir [SQV]) and six RT ... See full document
8
Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... (1/5, 1/25, and 1/125) and added to a 96-well plate with poly(rA) (enzyme template) bound to the bottom of the wells and with 150 l of reaction solution containing bromodeoxyuridine triphosphate as ... See full document
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Naïve T-Cell Depletion Related to Infection by X4 Human Immunodeficiency Virus Type 1 in Poor Immunological Responders to Highly Active Antiretroviral Therapy
... naı¨ve cell loss in the periph- ...naı¨ve- T-cell pool by the direct killing of target cells or by bystander apoptosis and activation-induced ...naı¨ve T cells harboring HIV-1 DNA does ... See full document
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Stoichiometry of Monoclonal Antibody Neutralization of T-Cell Line-Adapted Human Immunodeficiency Virus Type 1
... humoral immunity against a viral infection may depend on the stoichiometry of antibody-mediated virus ...that virus neutralization can be ac- complished by the binding of four monoclonal antibodies ... See full document
7
Inducible human immunodeficiency virus type 1 packaging cell lines.
... vector virus transfer, drug-resistant HeLaT4 tar- get cells were cloned and the genomic DNA isolated from them was subjected to Southern ...GPT-resistant cell clones contained HVP, HSN, ... See full document
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A Human T-Cell Leukemia Virus Type 1 Regulatory Element Enhances the Immunogenicity of Human Immunodeficiency Virus Type 1 DNA Vaccines in Mice and Nonhuman Primates
... 28. Seiki, M., S. Hattori, Y. Hirayama, and M. Yoshida. 1983. Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. ... See full document
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Novel Pathway for Induction of Latent Virus from Resting CD4+ T Cells in the Simian Immunodeficiency Virus/Macaque Model of Human Immunodeficiency Virus Type 1 Latency
... hybrid cell line generated by fusing ...Epstein-Barr virus (EBV)-transformed, human B-lymphoblastoid cell line (LCL), with CEM, a CD4 ⫹ human T-cell tumor line ...healthy ... See full document
11
Early Induction and Maintenance of Env-Specific T-Helper Cells following Human Immunodeficiency Virus Type 1 Infection
... deficiency virus type 1 (HIV-1) ...the induction and evolution of Th responses following acute infection, we prospectively analyzed Env- and Gag-specific Th responses longitudinally for ... See full document
12
Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights for Better Antiviral Therapy
... the human immunodeficiency virus type 1 (HIV-1) protease inhibitors is regarded as a major success of structure-based drug design (16, 36, ...active antiretroviral ... See full document
10
Demonstration of Sustained Drug-Resistant Human Immunodeficiency Virus Type 1 Lineages Circulating among Treatment-Naïve Individuals
... of human immunodeficiency virus (HIV) drug resistance is well-recognized and compromises response to first-line ...of resistant viruses circulating in untreated ...HIV type ... See full document
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Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.
... in antiretroviral activity as measured by the reduction of HIV-1 p24 antigen and infectious virion release ...KWW cell lines plateaued at the end of the experiments, indicating viral cytopathic ... See full document
8
Sensitive Phenotypic Detection of Minor Drug Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
... that drug- resistant variants exist prior to antiretroviral ...the virus population is determined by its fitness (replication potential) relative to that of other viral variants exposed to the ... See full document
9
Transfer of Specificity for Human Immunodeficiency Virus Type 1 into Primary Human T Lymphocytes by Introduction of T-Cell Receptor Genes
... active antiretroviral therapy, due to the fall in precursor frequency of CTL to HIV following the reduction in viral burden ...the T cells that can be isolated from infected individuals are often terminally ... See full document
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