[PDF] Top 20 Induction and Characterization of Neutralizing Antibodies against a Human Immunodeficiency Virus Type 1 Primary Isolate
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Induction and Characterization of Neutralizing Antibodies against a Human Immunodeficiency Virus Type 1 Primary Isolate
... of neutralizing antibodies by recombinant DH012 ...tent neutralizing activity raised the possibility of reproducing this activity by immunizing animals with DH012 ...DH012 virus, although the ... See full document
5
Vaccine-Elicited V3 Loop-Specific Antibodies in Rhesus Monkeys and Control of a Simian-Human Immunodeficiency Virus Expressing a Primary Patient Human Immunodeficiency Virus Type 1 Isolate Envelope
... the virus inoculum and antibodies were removed by three washes with 200 l of growth ...in virus control wells had reached peak concentrations, which is when optimum sensitiv- ity is achieved in this ... See full document
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Sequential Immunization with V3 Peptides from Primary Human Immunodeficiency Virus Type 1 Produces Cross-Neutralizing Antibodies against Primary Isolates with a Matching Narrow-Neutralization Sequence Motif
... antiviral neutralizing antibody responses of anti-V3 an- tibodies lies in the extraordinary diversity of the V3 sequence and in the resulting strict type specificity of anti-V3 neutraliz- ing ...strict ... See full document
11
Identification of gp120 Regions Targeted by a Highly Potent Neutralizing Antiserum Elicited in a Chimpanzee Inoculated with a Primary Human Immunodeficiency Virus Type 1 Isolate
... ing virus (17, 33). The isolation of only three human monoclo- nal antibodies possessing broad, high-titered virus-neutralizing activities over the nearly two decades of the AIDS ... See full document
6
CXCR4-Dependent Infection of CD8+, but Not CD4+, Lymphocytes by a Primary Human Immunodeficiency Virus Type 1 Isolate
... of primary CD4 ⴙ and CD8 ⴙ ...93US143-T8 isolate is known to effi- ciently infect both CD4 ⫹ and CD8 ⫹ ...93US143 isolate, forms syncytia in T-cell lines, indicative of the SI phenotype ...93US143-T8 ... See full document
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Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication
... CCR5 binding of gp120 glycoproteins from CD4-indepen- dent viruses. The ability of HIV-1 gp120 to bind CCR5 is dependent on prior CD4 binding (68, 72). To examine whether the acquisition of CD4 independence ... See full document
7
Characterization of Antibody Responses Elicited by Human Immunodeficiency Virus Type 1 Primary Isolate Trimeric and Monomeric Envelope Glycoproteins in Selected Adjuvants
... Env-pseudotyped virus neutralization and luciferase reporter cell ...after virus infection, the cells were lysed, and RLU were measured using black solid OptiPlates-96F plates (PerkinElmer, Boston, MA) and ... See full document
13
Neutralizing antibodies against the V3 loop of human immunodeficiency virus type 1 gp120 block the CD4-dependent and -independent binding of virus to cells.
... loop antibodies completely inhibit the interaction of virus-associated gp120 with CD4 1 cells, without an apparent effect on the CD4 binding domain in gp120, suggest a direct or an indirect role of ... See full document
10
V3-independent determinants of macrophage tropism in a primary human immunodeficiency virus type 1 isolate.
... Human immunodeficiency virus type 1 isolates differ in their ability to productively infect macrophages, and several groups have mapped the genetic basis for macrophage tropism to ... See full document
7
Human immunodeficiency virus type 1-neutralizing monoclonal antibodies which react with p17 core protein: characterization and epitope mapping.
... 267-272 0022-538X/89/010267-06$02.00/0 Copyright X 1989, American Society for Microbiology Human Immunodeficiency Virus Type 1-Neutralizing Monoclonal Antibodies Which React with p17 Cor[r] ... See full document
6
Heterogeneity of Envelope Molecules Expressed on Primary Human Immunodeficiency Virus Type 1 Particles as Probed by the Binding of Neutralizing and Nonneutralizing Antibodies
... argues against the negative-cooperativity ...a neutralizing Ab coating density of between one and two Ab molecules bound per envelope ...a primary HIV-1 ...Abs against TCLA viruses ... See full document
13
Determinants of Entry Cofactor Utilization and Tropism in a Dualtropic Human Immunodeficiency Virus Type 1 Primary Isolate
... for human immunodeficiency virus type 1 (HIV-1) tropism has been clarified recently with the discovery that chemokine receptors, members of the large seven-trans- membrane family ... See full document
7
Induction of Epitope-Specific Neutralizing Antibodies against West Nile Virus
... some human sera contained DIII-lr IgG, whereas others did ...response against the DIII-lr epitope and clinical ...IgG against this epitope does not contribute significantly to protection ... See full document
12
Cross-Subtype Neutralizing Antibodies Induced in Baboons by a Subtype E gp120 Immunogen Based on an R5 Primary Human Immunodeficiency Virus Type 1 Envelope
... for 1 h. Pre- and postimmune sera were diluted 1:1,000 in 5% nonfat dry milk in PBS and incubated with peptides for 2 h at room ...at 1:1,000 for 1 ...reactivity against 20 background ... See full document
11
Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex.
... by virus or cell culture conditions, which have been suggested to influence HIV-1 neutralization (56, ...[Table 1]) can be detected by this ... See full document
7
Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L
... broadly neutralizing antibodies is an important goal of HIV vaccine design efforts, and the study of broadly neu- tralizing monoclonal antibodies (bnMAbs) can assist in that ...goal. Human ... See full document
12
Susceptibility of Recently Transmitted Subtype B Human Immunodeficiency Virus Type 1 Variants to Broadly Neutralizing Antibodies
... initial virus replication in a newly infected individual, before the appearance of neutraliz- ing antibodies, neutralization-sensitive virus variants may be preferentially selected based on their ... See full document
10
Dissection of Human Immunodeficiency Virus Type 1 Entry with Neutralizing Antibodies to gp41 Fusion Intermediates
... the human lymphoid cell line TF228.1.16, which stably expresses HIV-1 IIIB/BH10 envelope ...ies against gp120 (2G12; IGb12) (National Institutes of Health AIDS Reagent Repository, McKesson ... See full document
11
Factors Associated with the Development of Cross-Reactive Neutralizing Antibodies during Human Immunodeficiency Virus Type 1 Infection
... 4E10-like antibodies. Alterna- tively, the titer of these antibodies in VC10028 is low and not sufficient to neutralize all isolates ...QH0692 virus but plasma collected ...and ... See full document
16
Improved Induction of Antibodies against Key Neutralizing Epitopes by Human Immunodeficiency Virus Type 1 gp120 DNA Prime-Protein Boost Vaccination Compared to gp120 Protein-Only Vaccination
... sera against the monovalent JR-FL gp120 antigen were generated in a previous study ...polyvalent primary gp120 formulation used in our recent clinical study ... See full document
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