[PDF] Top 20 Induction of Gag-Specific CD4 T Cell Responses during Acute HIV Infection Is Associated with Improved Viral Control
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Induction of Gag-Specific CD4 T Cell Responses during Acute HIV Infection Is Associated with Improved Viral Control
... that HIV-specific T cells responding to different antigens may have divergent functional ...Env-specific T cells may be more critical to support neutral- izing antibody production, ... See full document
10
Induction of Gag-specific CD4 T cell responses during acute HIV infection is associated with improved viral control
... H. Induction of Gag- specific CD4 T cell responses during acute HIV infection is associated with improved viral ... See full document
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Robust Gag specific T cell responses characterize viremia control in HIV 2 infection
... of HIV-1 epitopes is determined early in infection and is seldom modified in chronic infection ...that responses to conserved parts of the genome, such as the capsid region of HIV-2 ... See full document
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Early Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8+ T-Cell Antiviral Activity and Correlates with Preservation of the CD4+ T-Cell Compartment
... alleles associated with delayed progression to AIDS contribute strongly to the initial CD8( ⫹) T cell response against ...Schaefer T, Verma P, Toth I, Block B, Baker B, Rothchild A, Lian J, ... See full document
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Enhanced Anti-HIV Functional Activity Associated with Gag-Specific CD8 T-Cell Responses
... CD8 T cells from high Gag responders displayed an overall more polyfunctional cytokine profile upon stimulation with HIV peptide pools, with significantly more 2- and 3-function T cells than ... See full document
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HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses
... Antigen-specific CD4 ⴙ T helper cell responses have long been recognized to be a critical component of effective vaccine immu- ...nity. CD4 ⴙ T cells are necessary to ... See full document
13
Strong Human Endogenous Retrovirus-Specific T Cell Responses Are Associated with Control of HIV-1 in Chronic Infection
... the HIV-1 TAFTIPSI response. To further characterize P2’s responses to the two similar peptides, HERV-K FI8 and HIV-1 TI8, we evaluated the functionality and phenotypes of the CD8 ⫹ T ... See full document
9
HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome
... that HIV-specific CD4 T cell responses contribute to viral control during chronic HIV ...while HIV-specific CD4 T cells ... See full document
7
Acute-Phase CD4+ T Cell Responses Targeting Invariant Viral Regions Are Associated with Control of Live Attenuated Simian Immunodeficiency Virus
... (MHC)-independent viral control, to evaluate characteristics of effective cel- lular responses mounted by Mauritian cynomolgus macaques (MCMs) that express the M3 MHC haplotype, which has been ... See full document
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A High Viral Burden Predicts the Loss of CD8 T-Cell Responses Specific for Subdominant Gag Epitopes during Chronic Human Immunodeficiency Virus Infection
... primary HIV infection may be an important parameter associated with ...of Gag-specific T-cell responses during the chronic phase of HIV ... See full document
7
Definition of the viral targets of protective HIV 1 specific T cell responses
... included responses in the same individual towards epitopes located in beneficial and non-beneficial OLP; with the former overall being more ...autologous viral sequence com- pared to epitopes located in ... See full document
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Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression
... events during early stages of human immunodeficiency virus type 1 (HIV-1) infection is critical for understanding the course of ...of HIV-1-specific T-cell gamma ... See full document
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Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection
... the CD4 ⴙ T cell compartment, high viremia, and a cytokine storm characterize the early days after HIV infec- ...emerging HIV-specific CD8 ⴙ T cell responses ... See full document
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Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4+ T Cells
... of HIV-1-spe- cific CD8 ⫹ T-cell responses with the slopes of CD4 ⫹ T-cell decline using data from the MACS cohort, for which CD4 ⫹ T-cell slopes are ... See full document
8
Multifunctional Human Immunodeficiency Virus (HIV) Gag-Specific CD8+ T-Cell Responses in Rectal Mucosa and Peripheral Blood Mononuclear Cells during Chronic HIV Type 1 Infection
... ⫹ T-cell response magnitude and CD4 ⫹ T-cell count indicates improved mucosal CD8 ⫹ T-cell function when CD4 ⫹ T-cell “help” is present (24, ... See full document
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Control of HIV-1 Pathogenesis in Viremic Nonprogressors Is Independent of Gag-Specific Cytotoxic T Lymphocyte Responses
... stable CD4 ⫹ T cell counts despite high levels of HIV-1 ...factors associated with this atypical control of the HIV infection have been poorly ...specific T ... See full document
10
Defining kinetic properties of HIV-specific CD8 T-cell responses in acute infection
... and viral load may indicate that a larger breadth is associated with viral ...in viral load (or vice versa). To determine if individual epitope-specific CD8 + T cells contribute ... See full document
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Viral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection
... in HIV-1 is one of the highest in nature, and a striking degree of viral genetic diversity is observed within HIV-1-infected individuals 13 ...the viral reverse transcriptase, a high rate of ... See full document
8
Polyfunctional CD4+ T-Cell Induction in Neutralizing Antibody-Triggered Control of Simian Immunodeficiency Virus Infection
... memory CD4 ⴙ T cells and delayed induction of neutralizing antibody (NAb) responses are characteristics of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) ... See full document
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FoxP3+ CD25+ CD8+ T-Cell Induction during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques Correlates with Low CD4+ T-Cell Activation and High Viral Load
... (HIV) infection but may influence viremia during primary infection, thereby possibly affecting long-term disease ...regulatory T cells may contribute to HIV/simian ... See full document
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