[PDF] Top 20 Inferring the function of genes from synthetic lethal mutations
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Inferring the function of genes from synthetic lethal mutations
... More recent studies have begun to reveal the limitations of single mutant experiments [2]. The problem is that biological systems have evolved robust mechanisms to compensate for single points of failure. These include ... See full document
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A Screen for Dynein Synthetic Lethals in Aspergillus nidulans Identifies Spindle Assembly Checkpoint Genes and Other Genes Involved in Mitosis
... not lethal, severely impairs nuclear ...dynein function in A. nidulans, we searched for synthetic lethal mutations that significantly reduced growth in the absence of dynein but had ... See full document
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Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer
... Beginning from the between-pathway model [13, 14], synthetic lethality (SL) has often been associated with compensatory or parallel pathways, such that the loss of function of one of the pathways ... See full document
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Diverse Functions of Spindle Assembly Checkpoint Genes in Saccharomyces cerevisiae
... all mutations in nonessential genes that function in chromosome segregation would respond identically with respect to spindle checkpoint ...were genes of unknown ...checkpoint genes ... See full document
13
Identification of potential synthetic lethal genes to p53 using a computational biology approach
... p53 mutations, about 80% of which are missense mutations ...p53 mutations are needed. Because tumor suppressor genes such as p53 are not druggable, it is rational to develop anticancer agents ... See full document
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Co-lethality studied as an asset against viral drug escape: the HIV protease case
... potential synthetic lethals (SLs are groups of survivable mutations which are lethal whenever any two ...vital function and invariance, these targets are unique in that they might minimize or ... See full document
13
THE CIS-TRANS TEST SHOWS NO EVIDENCE FOR A FUNCTIONAL RELATIONSHIP BETWEEN TWO MOUSE t COMPLEX LETHAL MUTATIONS: IMPLICATIONS FOR THE EVOLUTION OF t HAPLOTYPES
... T h e level of complementation could also be affected by deleterious genes, other than the specific lethal mutations, carried by individual t haplotypes... To test [r] ... See full document
13
Mutations Synthetically Lethal With tpm1Δ Lie in Genes Involved in Morphogenesis
... The finding that tpmlA does not show general synthetic lethality with a number of irrelevant conditional lethal mutations and that the tsl mutations all give rise [r] ... See full document
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Variations in Genetic Recombination Due to Amber Mutations in T4D Bacteriophage
... We selected amber conditional lethal mutations in 11 early function genes and 1 late function gene of T4D bacteriophage and attempted to ascertain their effect on recombination and on he[r] ... See full document
5
The Purine Synthesis Gene Prat2 Is Required for Drosophila Metamorphosis, as Revealed by Inverted-Repeat-Mediated RNA Interference
... Prat2 genes are both highly conserved with PRAT sequences from prokaryotes and ...pupal lethal phenotypes, suggesting that Prat and Prat2 have partially additive functions during Drosophila ... See full document
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Modelling genotype–phenotype relationships and human disease with genetic interaction networks
... data from model organisms (Lehner and Fraser, ...of genes that are synthetically lethal in ...synthetically lethal in ...to mutations in single genes; >60% of the orthologs of ... See full document
8
Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome.
... It is possible that among the zygotic lethal mutations that are also germline cell lethals, there exists a set of genes that exhibit very specific maternal effects o[r] ... See full document
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ESSENTIAL GENES AND DEFICIENCIES IN THE UNC-22 IV REGION OF CAENORHABDITIS ELEGANS
... The lethal mutations will be tested for suppression by the informational suppressor, sup-7 X, to identify null alleles of the let genes (WATERSTON 1981). In addition to t[r] ... See full document
12
High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma
... lacks mutations in ...the synthetic lethality of HHT with VHL mutation in two tumorgraft lines represents proof-of-principle that this screening strategy can successfully identify compounds that may be ... See full document
12
COLD-SENSITIVE CELL-DIVISION-CYCLE MUTANTS OF YEAST: ISOLATION, PROPERTIES, AND PSEUDOREVERSION STUDIES
... Genes devoted primarily to cell divi- sion were recognized by the phenotypes of conditional-lethal (temperature- sensitive) mutations; at nonpermissive temperature, cdc (for ce[r] ... See full document
17
Lethal and amanitin-resistance mutations in the Caenorhabditis elegans ama-1 and ama-2 genes.
... (GREENLEAF et al. T h e mapping data obtained for the other amani- tin-resistance mutations indicate that they are alleles of ama-I. Another eight amanitin- resistance [r] ... See full document
14
Genetic analysis of chromosomal region 67A-D of Drosophila melanogaster.
... Complementation and mapping analysis of reces- sive lethal mutations: In order to (1) assign the lethal mutations isolated over Df(3L)ACI to complemen- tation groups and[r] ... See full document
15
ON LETHAL MUTATIONS IN NATURAL POPULATIONS
... Through investiga- tions of lethals it is possible to study the roles played by the basic factors of population genetics: natural selection, mutation pressure, and automatic [r] ... See full document
18
Cancer ppt
... 11.15 Cancer results from mutations in genes that control cell division.. • Mutations in two types of genes can cause cancer.[r] ... See full document
22
DOMINANT SUPPRESSORS OF A MUSCLE MUTANT DEFINE AN ESSENTIAL GENE OF CAENORHABDITIS ELEGANS
... The null phenotype of sup-11 is recessiue lethal: Null alleles of genes have been obtained by reversion of dominant “neomorphic” mutations (which result i n the acquisitio[r] ... See full document
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