[PDF] Top 20 Insights from mouse models into human retinoblastoma
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Insights from mouse models into human retinoblastoma
... DKO models confirm that p107 and p130 have differing func- ...distinct from that of ...to retinoblastoma detection and tumor penetrance differs strongly, with 100% of Rb/p130 DKO animals developing ... See full document
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Mammary epithelial cell transformation: insights from cell culture and mouse models
... adult human cancers are carcinomas, tumors originating from malignant transformation of epithelial ...comes from fibroblast transformation ...originate from cells lining the milk-forming ducts ... See full document
9
The Many Flavors of Hyperhomocyst(e)inemia: Insights from Transgenic and Inhibitor Based Mouse Models of Disrupted One Carbon Metabolism
... Mouse models that perturb homocysteine metabolism, including genetic mouse models that result in defi- ciencies of methylenetetrahydrofolate reductase, methionine synthase, methionine synthase ... See full document
12
Insights into insulin resistance and type 2 diabetes from knockout mouse models
... secretion from pancreatic β cells seen in type 2 diabetes (1, 2) may be genetic in origin or may be augmented by environmental factors and by ongoing hyperglycemia ...of human type 2 diabetes (1, 2, ... See full document
8
Uterine disorders and pregnancy complications: insights from mouse models
... of human uterine physiology and pathology has been extrapolated from the study of diverse animal models, as there is no ideal system for studying human uterine biology in ...whether ... See full document
13
Cross-species genomic and epigenomic landscape of retinoblastoma
... that mouse retinoblastomas faithfully recapitulate the molecular and cellular features of human ...of retinoblastoma initiation was indistinguishable across the 6 strains, tumor penetrance and the ... See full document
16
Cooperation between Rb and Arf in suppressing mouse retinoblastoma
... Human retinoblastoma has been proposed to arise from a benign lesion, termed retinoma ...of human retinoma studies is that the lesions are studied in the presence of late-stage ... See full document
9
Genetically engineered mouse models and human osteosarcoma
... clinical insights in trialing new treatment ...experimental models of human OS. Such models can serve as a preclinical platform for the identification of new therapeutic targets and the in ... See full document
14
Mouse models of breast cancer in preclinical research
... Xenograft models are used to elucidate the underlying mechanisms of resistance, and genetically engineered mouse models (GEMMs) are also useful to understand the mechanisms involved in the ... See full document
6
Efficacy and safety of aflibercept in in vitro and in vivo models of retinoblastoma
... orthotopic mouse models were created by injecting Y-79 cells subcutaneously and intravitreally, ...of retinoblastoma, animals were intraperitoneally injected with aflibercept (25 mg/kg body weight) ... See full document
10
<p>Innate Immunity and Cell Surface Receptors in the Pathogenesis of COPD: Insights from Mouse Smoking Models</p>
... Female smokers have an increased risk of developing COPD and disease progression compared with male smo- kers with a similar smoke history. 9 – 12 The causes and mechanism(s) for sexual dimorphism in the risk for COPD ... See full document
12
Signaling to Cardiac Hypertrophy: Insights from Human and Mouse RASopathies
... Evidence from cultured cardiac myocytes exposed to a MEK1-specific inhibitor demonstrated the critical contribution of the ERK path- way to hypertrophy ...genetic models of hypertrophy ...in human ... See full document
10
The α2β1 integrin is a metastasis suppressor in mouse models and human cancer
... the human expres- sion data focus on integrin expression or lack of integrin expression by the mammary epithelial ...loss from the malignant tumor in tumor ... See full document
13
Hemopexin in severe inflammation and infection: mouse models and human diseases
... Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. Extracellular hemoglobin and secondarily released heme amplify inflammation in the presence of microbial TLR ligands ... See full document
8
Diffuse anterior retinoblastoma: current concepts
... But to probe into the chemotherapy regimens and determine the standard chemotherapy, we still need more long-term clinical trials to investigate the therapeutic effect of treatment options that are individual or as a ... See full document
7
β-catenin stabilization enhances SS18-SSX2 -driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition
... Synovial sarcoma (SS) is the most common soft- tissue sarcoma diagnosed during adolescence and young adulthood [1]. Clinically recalcitrant to traditional cytotoxic chemotherapy in most cases, once metastatic, SS is ... See full document
9
Human taeniasis: current insights into prevention and management strategies in endemic countries
... Abstract: Human taeniasis is a zoonotic condition resulting from infection with the adult stages of Taenia saginata (“beef tapeworm”), Taenia solium (“pork tapeworm”) or Taenia asiatica (“Asian ...of ... See full document
10
Antioxidant and antiproliferative activities of Abrus precatorius leaf extracts an in vitro study
... Background: The use of traditional medicine at the primary health care level is widespread and plant-based treatments are being recommended for curing various diseases by traditional medical practitioners all over the ... See full document
12
Advanced model systems and tools for basic and translational human immunology
... data from a wide variety of ...bioinformatic models by integrating data from multiple studies ...silico models can be used to identify putative pre- dictive markers that can be validated with ... See full document
14
The utilization of humanized mouse models for the study of human retroviral infections
... SHIV models in rhesus and pigtail macaques have provided some success as surrogates for HIV-1 infection in ...to human AIDS [53] suggesting that this model holds further ... See full document
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