[PDF] Top 20 Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex
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Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex
... of protein nuclear import have been described so far, the most extensively characterized of which is known as the classical pathway and is utilized by basic-type NLSs (34, 35, ...importin-a/b ... See full document
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Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme.
... feline immunodeficiency virus, caprine arthritis-encephalitis virus, visna-maedi virus, or equine infectious anemia virus, contain in their genomes, as an integral part of the pol gene, ... See full document
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Importin-α Promotes Passage through the Nuclear Pore Complex of Human Immunodeficiency Virus Type 1 Vpr
... in Vpr that contributes to the interac- tions with importin- ␣ , we examined various mutant forms of Vpr in a pull-down assay using GST-tagged importin- ␣ ...As protein sources, we used lysates of ... See full document
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Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.
... fusion protein in ...encoding Vpr or a mutant form of Vpr, VprX, for subsequent cell cycle analysis [see ...direct interaction between Vpr and the full- length HHR23A and confirms and ... See full document
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Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation.
... that Vpr function may also require the de novo synthesis of this protein, as the virion-associated protein alone was insufficient to augment replication in cell types such as macrophages ... See full document
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Phosphorylation of Human Immunodeficiency Virus Type 1 Vpr Regulates Cell Cycle Arrest
... Human immunodeficiency virus 1 (HIV-1) primarily targets CD4 T cells and macrophages (10, ...(Vif, Vpr, Tat, Rev, Vpu, and Nef) that are important in viral replication and ... See full document
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Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis through Caspase Activation
... 96-amino-acid protein termed Vpr. Analysis of the HIV-1 virion has demonstrated that Vpr is found associated with the viral particle through an association with the Gag p6 molecule (31, 33, ... See full document
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Transdominant Activity of Human Immunodeficiency Virus Type 1 Vpr with a Mutation at Residue R73
... mutant Vpr prompted us to examine cellular compartmentalization of this protein in the test ...expressing Vpr fused to the green fluorescent protein (GFP) were constructed and intro- duced ... See full document
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Isolation of Human Immunodeficiency Virus Type 1 Cores: Retention of Vpr in the Absence of p6gag
... host protein that is specifically incorporated into HIV-1 virions via an interaction with CA (7, 9, ...of Vpr, after passage through a layer containing ... See full document
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Biochemical Analyses of the Interactions between Human Immunodeficiency Virus Type 1 Vpr and p6Gag
... Human immunodeficiency virus type 1 (HIV-1) encodes a 97-amino-acid accessory protein called Vpr (an initialism for viral protein ...Although Vpr is ... See full document
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Cytoplasmic Utilization of Human Immunodeficiency Virus Type 1 Genomic RNA Is Not Dependent on a Nuclear Interaction with Gag
... is complex and only incompletely understood (5, 48, 56). A transient nuclear phase of uncleaved HIV-1 Gag late in the replication cycle seemed possible when NLS and NES were identified in Gag but has ... See full document
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Human Immunodeficiency Virus Type 1 Vpr Links Proteasomal Degradation and Checkpoint Activation
... Cullin complex and increases E3 ligase activity ...the complex, rendering it inactive by allowing interaction with CAND1 ...of Vpr and found that overexpression of Vpr and DCAF1 led to ... See full document
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A Human Nuclear Shuttling Protein That Interacts with Human Immunodeficiency Virus Type 1 Matrix Is Packaged into Virions
... this type are recognized by the protein Crm1/exportin 1 (20, ...45). Nuclear export is mediated by complex formation between an NES-containing protein, Crm1, and ...trimeric ... See full document
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Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Functions as an Immediate-Early Protein during HIV-1 Infection
... incorporate Vpr at com- parable levels, similar amounts of each virus preparation (with the same RT activity) were lysed in Laemmli buffer and viral proteins were separated on sodium dodecyl ... See full document
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Human immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles
... the Vpr dimer and oli- gomers through molecular docking based on the available full length monomer structure ...of Vpr in ...of Vpr mutants I60A and I67A indicated that these residues play a major ... See full document
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Two Putative α-Helical Domains of Human Immunodeficiency Virus Type 1 Vpr Mediate Nuclear Localization by at Least Two Mechanisms
... {0.15 M NaCl, 0.05 M Tris-HCl [pH 8.5], 5 mM 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonic acid [CHAPS; Sigma]} with a cocktail of protease inhibitors (Boehringer Mannheim Biochemicals) and centrifuged ... See full document
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A Mutation in the Human Immunodeficiency Virus Type 1 Gag Protein Destabilizes the Interaction of the Envelope Protein Subunits gp120 and gp41
... HIV-1 virus-cell fusion ...with Vpr. P4R5 target cells were inoculated with HIV-1 particles containing BlaM; cells were subsequently loaded with CCF2-AM, a cell-permeable fluorescent substrate ... See full document
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Nuclear Import of the Preintegration Complex Is Blocked upon Infection by Human Immunodeficiency Virus Type 1 in Mouse Cells
... uninfected human cells (11, 52), indicating that the defects are due to the lack of necessary factors in rodent cells rather than the presence of dominant inhibitors of HIV-1 ...a nuclear export ... See full document
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Interaction of Human Immunodeficiency Virus Type 1 Tat with the Transcriptional Coactivators p300 and CREB Binding Protein
... Human immunodeficiency virus type 1 (HIV-1) encodes the transactivator protein Tat, which is essential for viral replication and progression to ...biochemical ... See full document
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The human immunodeficiency virus type 1 Vpr protein and its carboxy-terminally truncated form induce apoptosis in tumor cells
... wild-type Vpr or C81, or the control ...wild-type Vpr or C81, or the control pME18Neo-Flag, together with ...wild-type Vpr or C81, or the control pME18Neo-Flag with or without ... See full document
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