[PDF] Top 20 Poly(C)-Binding Protein 2 Interacts with Sequences Required for Viral Replication in the Hepatitis C Virus (HCV) 5′ Untranslated Region and Directs HCV RNA Replication through Circularizing the Viral Genome
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Poly(C)-Binding Protein 2 Interacts with Sequences Required for Viral Replication in the Hepatitis C Virus (HCV) 5′ Untranslated Region and Directs HCV RNA Replication through Circularizing the Viral Genome
... of HCV replicons with various deletions of HCV 5 ⴕ UTR to determine the replication ...the 5 ⬘ UTR are required for RNA repli- cation, we constructed a series of mutant replicons ... See full document
11
Roles of the 5′ Untranslated Region of Nonprimate Hepacivirus in Translation Initiation and Viral Replication
... genomic RNA possesses an open reading frame (ORF) of a polyprotein flanked by 5= and 3= untranslated regions ...The HCV 5= UTR forms highly conserved secondary and tertiary structures ... See full document
18
Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.
... positive-stranded RNA genome of approximately ...individual HCV isolates, the 3 * -end 98 nucleotides (nt) of the HCV RNA, which constitute part of the 3 * -untranslated ... See full document
9
Regulation of Hepatitis C Virus Genome Replication by Xrn1 and MicroRNA-122 Binding to Individual Sites in the 5′ Untranslated Region
... SGR HCV RNA, and miR-122 (miR-122 dependent) or miControl (miR-122 ...independent). Replication was measured by evaluating luciferase production at the indicated time points post-second ...subgenomic ... See full document
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HMGB1 Promotes Hepatitis C Virus Replication by Interaction with Stem-Loop 4 in the Viral 5′ Untranslated Region
... sense HCV as foreign invaders through pathogen-associated mo- lecular pattern (PAMP) recognition to activate the innate im- mune ...for HCV detection include RIG-I (retinoic acid inducible gene ... See full document
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hnRNP A1 Interacts with the 5′ Untranslated Regions of Enterovirus 71 and Sindbis Virus RNA and Is Required for Viral Replication
... positive-strand RNA genome of approximately 7,400 nucle- otides ...the genome is translated in a cap-independent manner into a single polyprotein, which is subsequently processed by virus-encoded ... See full document
9
Structural and Functional Elements of the Promoter Encoded by the 5′ Untranslated Region of the Venezuelan Equine Encephalitis Virus Genome
... the poly(A) tail (12, 13, 19); (ii) the subgenomic promoter in the negative-strand copy of the viral genome (25); and (iii) the promoter for the synthesis of the positive-strand viral ... See full document
13
Role of the 5′-Proximal Stem-Loop Structure of the 5′ Untranslated Region in Replication and Translation of Hepatitis C Virus RNA
... positive-strand RNA viruses, the 5⬘UTR has multiple important roles in the regulation of viral RNA trans- lation and/or replication (3, 4, 10, 18, 19, 22, 45, ...the 5⬘ end of ... See full document
7
Interactions of Viral Protein 3CD and Poly(rC) Binding Protein with the 5′ Untranslated Region of the Poliovirus Genome
... for replication, because a poliovirus RNA carrying the same mu- tation yields a nonviable virus with a major defect in transla- tion (13, ...the genome of a poliovirus subgenomic replicon in which ... See full document
8
The Pseudoknot Region of the 5′ Untranslated Region Is a Determinant of Viral Tropism and Virulence of Foot-and-Mouth Disease Virus
... FMDV 5= untranslated region (UTR) plays an important role during FMDV ...The 5= UTR is ⬎ 1,300 bp long and contains a short segment known as the S fragment, which follows the poly(C) ... See full document
17
Transmissible Gastroenteritis Coronavirus Genome Packaging Signal Is Located at the 5′ End of the Genome and Promotes Viral RNA Incorporation into Virions in a Replication-Independent Process
... genomic 5= ...genomic 5= end using a single-component system consisting of recombinant TGEV viruses that transcribed sgmRNAs, including potential packaging ...ectopic viral sequences between the ... See full document
12
Interplay of RNA Elements in the Dengue Virus 5′ and 3′ Ends Required for Viral RNA Replication
... UTR RNA is recognized only in the presence of the 5 ⬘ end sequence (16, ...the 5 ⬘ SLA RNA element and the presence of 5 ⬘ -3 ⬘ CS and UAR complementarity, but not the primary sequence, ... See full document
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A Stem-Loop Motif Formed by the Immediate 5′ Terminus of the Bovine Viral Diarrhea Virus Genome Modulates Translation as well as Replication of the Viral RNA
... 1. RNA primary and secondary structure of the BVDV DI9c 5⬘ termi- ...of 5⬘-terminal sequences of six representative pestivirus strains (BVDV-1 NADL, BVDV-1 SD-1, BVDV-1 Osloss, BVDV-2 890, CSFV ... See full document
11
A small yeast RNA selectively inhibits internal initiation of translation programmed by poliovirus RNA: specific interaction with cellular proteins that bind to the viral 5'-untranslated region.
... 11 0022-538X/94/$04.00+0 Copyright C 1994, American Society for Microbiology A Small Yeast RNA Selectively Inhibits Internal Initiation of Translation Programmed by Poliovirus RNA: Speci[r] ... See full document
12
An Optimal cis-Replication Stem-Loop IV in the 5′ Untranslated Region of the Mouse Coronavirus Genome Extends 16 Nucleotides into Open Reading Frame 1
... their 5 ⬘ UTRs would be in- terchangeable, as were their 3 ⬘ UTRs ...MHV 5 ⬘ UTR with the 210-nt BCoV 5 ⬘ UTR yielded no viable ...BCoV 5 ⬘ UTR structures in an effort to identify common ... See full document
13
Structure and function of a novel cap independent translation element in the 3' untranslated region of a viral RNA
... Because the mRNAs of BYDV gRNA, sgRNAl and sgRNA2 all contain the same 3'terminal sequence, they use a common translation element that allows expression of their mRNAs equivalent to that[r] ... See full document
111
The 5'-untranslated regions of picornavirus RNAs contain independent functional domains essential for RNA replication and translation.
... 4384-4391 0022-538X/94/$04.00+0 Copyright © 1994, American Society for Microbiology JOURNAL OF VIROLOGY, The 5'-Untranslated Regions of Picornavirus RNAs Contain Independent Functional D[r] ... See full document
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The 5′ Untranslated Region of the Major Immediate Early mRNA Is Necessary for Efficient Human Cytomegalovirus Replication
... MIE 5= UTR enhances mRNA translation in vitro. 5= UTRs can either enhance or inhibit translation depending on their length, sequence composition, the presence of RNA structure, and the cellular ... See full document
14
Novel cis-Acting Element within the Capsid-Coding Region Enhances Flavivirus Viral-RNA Replication by Regulating Genome Cyclization
... which RNA was isolated in ...(forward, 5=-CCCCG GAACAACAGTCACA-3=; reverse, 5=-TGCAGTGGTGGTCCTCAAAG- FIG 1 Structure prediction of DCS-PK among different mosquito-borne ...of 5=CS ... See full document
15
A bulged stem-loop structure in the 3' untranslated region of the genome of the coronavirus mouse hepatitis virus is essential for replication.
... essential RNA second- ary structure at the 5 9 end of the MHV 3 9 UTR, which was discovered through our initial unsuccessful efforts to substitute a nonhomologously spliced segment of the BCV 3 9 UTR ... See full document
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