[PDF] Top 20 Role of Invariant Thr80 in Human Immunodeficiency Virus Type 1 Protease Structure, Function, and Viral Infectivity
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Role of Invariant Thr80 in Human Immunodeficiency Virus Type 1 Protease Structure, Function, and Viral Infectivity
... with human immunodeficiency virus type 1 (HIV-1) is useful for inferring structural and/or functional constraints at specific residues within the viral ...are ... See full document
11
Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.
... by viral proteins such as Nef to promote downregu- lation of surface molecules involved in the immune ...intrinsic infectivity of HIV and to downregulate the surface expression of CD4 raises the question of ... See full document
10
Role of Human Immunodeficiency Virus Type 1 Integrase in Uncoating of the Viral Core
... novel function for HIV-1 IN, namely, to promote optimal stability of the viral ...the viral life cycle (10, 14, 17, 28, 44, 62, 64, 69), but to our knowledge, a requirement for IN during ... See full document
10
Role for Human Immunodeficiency Virus Type 1 Membrane Cholesterol in Viral Internalization
... the viral membrane, itself the result of the selective budding of this virus through lipid ...their structure and protein content. Further- more, the conserved infectivity of the ... See full document
9
Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... multidrug-resistant virus transmitted through sexual contact (B670), exhibited a novel characteristic: their behavior in GHOST cells and PBMCs was determined by the deficits imposed by the mutant RT rather than by ... See full document
10
Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity.
... of protease activity exists in an immature virion and that this reservoir can absorb a decrease in protease activity induced by point muta- tions in the ...the protease which affect the binding of ... See full document
8
Structure-function studies of the human immunodeficiency virus type 1 matrix protein, p17.
... of viral budding away from the plasma membrane toward in- tracellular vacuoles in this ...a virus that replicated with wild-type kinetics ...unidentified role in viral ... See full document
10
Ordered Processing of the Human Immunodeficiency Virus Type 1 GagPol Precursor Is Influenced by the Context of the Embedded Viral Protease
... critical role played by the orderly processing of the Gag and GagPol precursors in virus assembly and replica- tion, little is known about the factors that determine the order in which different sites are ... See full document
7
Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity and Replication Independently of Viral Coreceptor Tropism
... the viral envelope glycoprotein to CD4 and subsequent interactions with G protein-coupled coreceptors, usually CCR5 (R5) or CXCR4 (X4) (reviewed in reference ...support virus-cell fusion or change the ... See full document
5
Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease.
... the viral protease involve a specific region of this portion of the viral RNA and NC-precursor ...to protease-mediated cleavage was not limited to ...to function, albeit less ... See full document
10
The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivity.
... of virus maturation (36a) that closely resembles the effect of the P31L ...immature viral particles resembling a protease-defective mutant virus (30, 37) were also observed with gag (27) and ... See full document
7
Inhibition of human and simian immunodeficiency virus protease function by targeting Vpx-protease-mutant fusion protein into viral particles.
... the function of the Pol ...vaccinia virus-T7 expression system, we have demonstrated that proteolytically active Vpr- and Vpx-PR fusion proteins can be expressed and packaged into HIV-1 and HIV-2 Gag ... See full document
7
Virion Incorporation of Human Immunodeficiency Virus Type 1 Nef Is Mediated by a Bipartite Membrane-Targeting Signal: Analysis of Its Role in Enhancement of Viral Infectivity
... the infectivity phenotype did not always correlate with the ability of the respective virus to replicate in nonprestimulated primary ...that viral phenotypes in single-cycle replication assays ... See full document
8
Intravirion Processing of the Human Immunodeficiency Virus Type 1 Vif Protein by the Viral Protease May Be Correlated with Vif Function
... for viral infectivity in primary human cells and some transformed cell lines is undisputed, the question of how Vif might accomplish this task is still under ...Vif function, i.e., ... See full document
12
Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication.
... Table 1, neither the wild-type virus nor the V32I/V82I mutant showed any decrease in infectivity when the infection was done in the presence of the PR inhibitor at concentrations between ... See full document
5
Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity.
... The higher infectivity of the wild-type virus relative to that of the mutant viruses might not have been due to the higher number of viral particles as judged by RT activity, since dilut[r] ... See full document
7
Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease.
... a role in the Nef-mediated enhancement of virion infectivity. HIV-1 Nef contains a conserved proline-rich sequence which binds to the SH3 domains of a subset of Src family tyrosine kinases, including ... See full document
6
Maintenance of the Gag/Gag-Pol Ratio Is Important for Human Immunodeficiency Virus Type 1 RNA Dimerization and Viral Infectivity
... the human immunodeficiency virus type 1 (HIV-1), like that of other retroviruses, contains three major structural genes, gag, pol, and ...stem structure immediately ... See full document
8
Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Matrix
... HIV-1 infectivity, we made use of a previously described set of mutant HIV-1 pro- viruses that lack most or all of MA but are nevertheless able to replicate efficiently in MT4 T lymphoid cells ... See full document
6
The Secondary Structure of the Human Immunodeficiency Virus Type 1 Transcript Modulates Viral Splicing and Infectivity
... of human immunodeficiency virus type 1 (HIV-1) is dependent on the balanced expression of several viral ...with viral se- quences to properly process the single ... See full document
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