[PDF] Top 20 Involvement of Multiple Epitope-Specific Cytotoxic T-Lymphocyte Responses in Vaccine-Based Control of Simian Immunodeficiency Virus Replication in Rhesus Macaques
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Involvement of Multiple Epitope-Specific Cytotoxic T-Lymphocyte Responses in Vaccine-Based Control of Simian Immunodeficiency Virus Replication in Rhesus Macaques
... of control in two of the five controllers. Twelve Burmese rhesus macaques used in our previous SIVmac239 challenge experiment (28) were followed up in the present study (Table ...eight ... See full document
10
Long-Term Control of Simian Immunodeficiency Virus Replication with Central Memory CD4+ T-Cell Preservation after Nonsterile Protection by a Cytotoxic T-Lymphocyte-Based Vaccine
... of virus-specific CD8 ⴙ cytotoxic T-lymphocyte (CTL) responses is a promising strategy for AIDS vaccine ...disease control are attainable by CTL-based ... See full document
10
Vaccine-Induced Cellular Responses Control Simian Immunodeficiency Virus Replication after Heterologous Challenge
... the vaccine. Sequencing of all vaccine constructs revealed no env sequences, and Western blots were negative for antibody against Env (see ...the vaccine vectors, we hypothesized that the Env RY8 ... See full document
14
Durable Mucosal Simian Immunodeficiency Virus-Specific Effector Memory T Lymphocyte Responses Elicited by Recombinant Adenovirus Vectors in Rhesus Monkeys
... of vaccine-elicited SIV-specific T lym- phocytes at mucosal ...⫹ T lymphocyte responses elicited by rAd vectors in rhesus ...monkeys. Rhesus monkeys were subjected ... See full document
9
Vaccine-Elicited Memory Cytotoxic T Lymphocytes Contribute to Mamu-A*01-Associated Control of Simian/Human Immunodeficiency Virus 89.6P Replication in Rhesus Monkeys
... Gag-derived epitope peptides p11C (CTPYDINQM) and p17G (GSENLKSLY) were used at 1 g/ml for measuring antigen-specific CTL responses in Mamu-A*01 ⫹ and Mamu-A*02 ⫹ rhesus monkeys, ... See full document
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Mucosal Priming of Simian Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Responses in Rhesus Macaques by the Salmonella Type III Secretion Antigen Delivery System
... of virus administered 8 weeks later, it is unlikely that the failure to establish an infection in this animal simply reflects the odds of virus transmission across the rectal mucosa with a low-titer ... See full document
10
Control of Simian Immunodeficiency Virus Replication by Vaccine-Induced Gag- and Vif-Specific CD8+ T Cells
... effective T cell-based AIDS vaccine, it is critical to define the antigens that elicit the most potent re- ...ⴙ T cells can be important in control of the AIDS ...ⴙ T cells by ... See full document
9
Simian Immunodeficiency Virus (SIV) gag DNA-Vaccinated Rhesus Monkeys Develop Secondary Cytotoxic T-Lymphocyte Responses and Control Viral Replication after Pathogenic SIV Infection
... protected macaques from infection with a chimeric SIV/HIV (SHIV) challenge ...a vaccine approach in ...in macaques against a pathogenic SHIV challenge ... See full document
11
Impact of Cytotoxic-T-Lymphocyte Memory Induction without Virus-Specific CD4+ T-Cell Help on Control of a Simian Immunodeficiency Virus Challenge in Rhesus Macaques
... SIV replication, although plasma viremia became undetectable at week 12 in one animal in group I (R06-037) and one in group II ...SIV replication; plasma viral loads became undetectable after week 5 in five ... See full document
8
Gag-Specific Cytotoxic T-Lymphocyte-Based Control of Primary Simian Immunodeficiency Virus Replication in a Vaccine Trial
... AIDS vaccine efficacy in viral transmission between MHC-I-matched ...carrying multiple CTL escape mutations were able to replicate persistently in vivo, despite their dimin- ished replicative ...AIDS ... See full document
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A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge.
... in rhesus monkeys by priming with recom- binant vaccinia virus-SIV Gag and boosting with noninfectious virus-like particles ...with virus-like particles alone, nor did we compare the relative ... See full document
6
Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8+ T-Cell Responses in Rhesus Macaques
... the vaccine regimens tested in human immunode- ficiency virus (HIV) vaccine efficacy trials to date have either reduced the rate of HIV infection or reduced the level of HIV ...on T-cell- ... See full document
8
Trivalent Live Attenuated Influenza-Simian Immunodeficiency Virus Vaccines: Efficacy and Evolution of Cytotoxic T Lymphocyte Escape in Macaques
... human immunodeficiency virus type 1 (HIV-1) pandemic continues to be a global health ...effective vaccine has not yet been developed, and it is still unclear what a successful vaccination approach ... See full document
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Transmission of Simian Immunodeficiency Virus Carrying Multiple Cytotoxic T-Lymphocyte Escape Mutations with Diminished Replicative Ability Can Result in AIDS Progression in Rhesus Macaques
... prophylactic vaccine using a Sendai virus vector expressing SIVmac239 Gag and shown its protec- tive efficacy against SIVmac239 challenge in a group of Bur- mese rhesus macaques (Macaca ... See full document
6
Cytotoxic T-Lymphocyte Escape Does Not Always Explain the Transient Control of Simian Immunodeficiency Virus SIVmac239 Viremia in Adenovirus-Boosted and DNA-Primed Mamu-A*01-Positive Rhesus Macaques
... largely based on a subset of well-studied MHC class I alleles known to bind T-cell ...Indian rhesus macaques can express more than 10 MHC class I alleles, although the contribution and cell ... See full document
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Impact of Vaccination on Cytotoxic T Lymphocyte Immunodominance and Cooperation against Simian Immunodeficiency Virus Replication in Rhesus Macaques
... virus control. Indeed, two of five animals in group IV failed to control SIV rep- ...express multiple anti- gens, of the vaccine-induced CTLs generated, only several ... See full document
8
Experimental Coinfection of Rhesus Macaques with Rhesus Cytomegalovirus and Simian Immunodeficiency Virus: Pathogenesis
... Naive rhesus macaques were inoculated with rhesus cytomegalovirus (RhCMV) followed 2 or 11 weeks later by inoculation with pathogenic simian immunodeficiency virus ...with ... See full document
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Elicitation of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Mucosal Compartments of Rhesus Monkeys by Systemic Vaccination
... cosal T lymphocytes in nonhuman primates and humans can be attributed at least in part to the difficulties associated with accessing these cell populations for ...intestinal T-cell responses in ... See full document
7
Novel Adeno-Associated Virus Vector Vaccine Restricts Replication of Simian Immunodeficiency Virus in Macaques
... SIV vaccine studies where the challenge viruses were ...vaccines based on modified vaccinia virus Ankara (MVA) vec- tors, monkeys were challenged with the same stock of SIVsm/ E660 used in our ... See full document
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Relative Dominance of Epitope-Specific Cytotoxic T-Lymphocyte Responses in Human Immunodeficiency Virus Type 1-Infected Persons with Shared HLA Alleles
... CTL responses to optimal epitopes from several HIV-1 gene products in multiple individuals matched at multiple class I ...percent specific lysis for each epitope and which epitopes were ... See full document
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