[PDF] Top 20 Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing
Has 10000 "Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing" found on our website. Below are the top 20 most common "Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing".
Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing
... Similar to other herpesviruses, KSHV can follow a latent or lytic replication programme in the infected host. The virus life cycle starts with replication in its primary target, B-cells from peripheral blood [8] and the ... See full document
24
Kaposi's Sarcoma-Associated Herpesvirus ORF57 Promotes Escape of Viral and Human Interleukin-6 from MicroRNA-Mediated Suppression
... which ORF57 disrupts miR-1293-mediated translational re- pression of vIL-6, we performed a CLIP assay in cotransfected HEK293 cells expressing ...in ORF57 binding and ...KSHV ORF57. Cell lysates from ... See full document
11
Kaposi's Sarcoma-Associated Herpesvirus ORF57 Is Not a Bona Fide Export Factor
... of ORF57, the presence or absence of ORF57 did not change the distribution of ORF59 RNA, as measured by the RNA C/N ratio (16, ...the ORF57-mediated accumulation of its target RNAs was not dependent ... See full document
6
Kaposi's Sarcoma-Associated Herpesvirus K-bZIP Protein Is Necessary for Lytic Viral Gene Expression, DNA Replication, and Virion Production in Primary Effusion Lymphoma Cell Lines
... and viral episome copy numbers to con- trol cells, indicating that K-bZIP does not play a role in viral episomal ...of orf57 and orf26 ...orf26 mRNA induction was ...the viral cycle ... See full document
12
Open Reading Frame 50 Protein of Kaposi's Sarcoma-Associated Herpesvirus Directly Activates the Viral PAN and K12 Genes by Binding to Related Response Elements
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is initi- ated by a single transactivator encoded in open reading frame (ORF) 50 of the viral genome (15, ...50 protein are transfected ... See full document
11
Kaposi’s Sarcoma Associated Herpesvirus Genome Programming during the Early Stages of Primary Infection of Peripheral Blood Mononuclear Cells
... Kaposi’s sarcoma-associated herpesvirus (KSHV) infection involves the dynamic expression of viral genes, which are temporally and epigenetically ...latent protein LANA and the immediate ... See full document
16
Kaposi's Sarcoma-Associated Herpesvirus ORF57 Functions as a Viral Splicing Factor and Promotes Expression of Intron-Containing Viral Lytic Genes in Spliceosome-Mediated RNA Splicing
... KSHV ORF57 functions as a viral splicing factor that promotes splicing of viral lytic ...an ORF57-null KSHV genome resulted in deficient viral RNA splicing, leading to accumula- tion of ... See full document
10
Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein Enhances mRNA Accumulation Independently of Effects on Nuclear RNA Export
... the ORF57 amino acid se- ...360. ORF57 is known to multimerize (24), and this region might therefore be important in homo- or heteromul- ...that ORF57 function is dependent on complex formation with ... See full document
9
Identification of the Physiological Gene Targets of the Essential Lytic Replicative Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein
... of ORF57. ORF57 has been suggested to act partly by enhancing the polyadenylation of target transcripts (12, 13, ...of ORF57-dependent transcripts in two discrete regions of the genome and the ... See full document
15
Kaposi sarcoma–associated herpesvirus: immunobiology, oncogenesis, and therapy
... since viral replication is the result of error-correcting, DNA-dependent DNA polymerases (the cellular DNA polymerase during latency and a viral KSHV-encoded DNA polymerase during lytic ...with ... See full document
12
Interplay between Polyadenylate-Binding Protein 1 and Kaposi's Sarcoma-Associated Herpesvirus ORF57 in Accumulation of Polyadenylated Nuclear RNA, a Viral Long Noncoding RNA
... orthobunyavirus, viral nucleocapsid protein binds to and colocal- izes with PABP in the cytoplasm early during infection, followed by nuclear retention of PABP ...but viral SOX does not directly ... See full document
14
Deletion of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein, vFLIP, from the Viral Genome Compromises the Activation of STAT1-Responsive Cellular Genes and Spindle Cell Formation in Endothelial Cells
... in primary effusion lymphoma cell lines led to induction of apoptosis and cell death (27, 31). In KS lesions, the expression of the vFLIP transcript was found to increase in late-stage lesions and was inversely ... See full document
14
Promoter- and Cell-Specific Transcriptional Transactivation by the Kaposi's Sarcoma-Associated Herpesvirus ORF57/Mta Protein
... for viral DNA replication to occur and progeny virions to be ...complete viral reactivation and ...productive viral reactivation, especially for optimal expression of DNA replication factors (37, ... See full document
16
Kaposi Sarcoma Herpesvirus Induces HO 1 during De Novo Infection of Endothelial Cells via Viral miRNA Dependent and Independent Mechanisms
... HO-1 mRNA as early as 4 h postinfection ...HO-1 protein levels fol- lowed similar biphasic kinetics, with an early peak of expression at 6 to 8 hpi and sustained expression during latency (3 to 21 ... See full document
11
Kaposi’s sarcoma associated herpesvirus G protein coupled receptor activates the canonical Wnt/β catenin signaling pathway
... components. Protein fractions were analyzed by Western blot with an anti- β -catenin ...VEGFA mRNA levels in BABE-vGPCR- and BABE-expressing HUVECs were analyzed by qRT-PCR in ... See full document
10
Kaposi's Sarcoma-Associated Herpesvirus K8 Is an RNA Binding Protein That Regulates Viral DNA Replication in Coordination with a Noncoding RNA
... ChIRP. The ChIRP protocol was adapted from that of Chu et al. (42). The probes were synthetic DNAs with BiotinTEG at the 3= end designed to be complementary to T1.4 RNA sequence using the online designer from Biosearch ... See full document
24
Computational Investigation of Marine Bioactive Compounds Reveals Frigocyclinone as a Potent Inhibitor of Kaposi’s Sarcoma Associated Herpesvirus (KSHV) Targets
... its interaction with the ligand. The interaction between a small molecule and a protein may result in inhibition of the protein. Molecular docking program Autodock 4.2 was used in this study. The ... See full document
14
Identification of Host-Chromosome Binding Sites and Candidate Gene Targets for Kaposi's Sarcoma-Associated Herpesvirus LANA
... by viral proteins appears to be an essential and common strategy for virus infection and persistence ...immediate-early protein RTA, which can relocalize STAT3 to its nuclear targets ...vFLIP protein ... See full document
11
Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is found in Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and tumors from patients with the plasmablastic variant of multicentric ... See full document
11
Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 ORF50/Rta Lytic Switch Protein Functions as a Tetramer
... ORF50 protein and molecular regulation of ...STAD protein functioned by forming mixed multimers with WT ...STAD protein contains all of the do- mains required for (i) Rta promoter association ... See full document
19
Related subjects