[PDF] Top 20 Large surface proteins of hepatitis B virus containing the pre-s sequence.
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Large surface proteins of hepatitis B virus containing the pre-s sequence.
... We found a larger protein, P39, and its glycosylated form, GP42, in hepatitis B virus particles and viral surface antigen filaments.. Immunological cross-reactions showed that P39/GP42 i[r] ... See full document
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Zinc-Dependent Interaction between JAB1 and Pre-S2 Mutant Large Surface Antigen of Hepatitis B Virus and Its Implications for Viral Hepatocarcinogenesis
... cells containing the gene expression vector pQCXIP. (B) Expression of HBs and HBc RNA and proteins in HuH7 cells transfected with ...HBS proteins were detected with two different antibodies: ... See full document
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Infection Process of the Hepatitis B Virus Depends on the Presence of a Defined Sequence in the Pre-S1 Domain
... by hepatitis B virus (HBV) contains distinct forms of viral ...and large (L) polypeptides, surrounds this ...these hepatitis B surface (HBs) proteins is initiated ... See full document
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The Pre-S1 and Antigenic Loop Infectivity Determinants of the Hepatitis B Virus Envelope Proteins Are Functionally Independent
... the virus. The HBV envelope proteins bear at least two deter- minants of viral entry: (i) the 75 first residues of pre-S1 (4, 30) and (ii) the conformational AGL determinant (2, ...The pre-S1 ... See full document
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The large surface protein of duck hepatitis B virus is phosphorylated in the pre-S domain.
... DISCUSSION The data presented here clearly demonstrate that a proportion of the large envelope protein of DHBV is modified by phosphorylation of serine and/or threonine residues within t[r] ... See full document
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Domains of the Hepatitis B Virus Small Surface Protein S Mediating Oligomerization
... and B-S ...indicated proteins were treated with trypsin in the absence or presence of the mild detergent ...The S protein was resistant to trypsin cleavage. The pre-S2 domain of the M ... See full document
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Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum.
... mutated proteins that are incompe- tent for secretion can cause stress in the ER, with resultant effects on cellular transcription via intracellular signaling path- ways (14, 21, ...the S pro- moter was ... See full document
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Dual topology of the large envelope protein of duck hepatitis B virus: determinants preventing pre-S translocation and glycosylation.
... DHBV large envelope protein in the mature virus particle. Virus particles which had been sepa- rated from serum proteins by sedimentation into a sucrose density gradient were used as starting ... See full document
8
Functional analysis of hepatitis B virus pre-s deletion variants associated with hepatocellular carcinoma
... from S promoter deletion variant-transfected cells (less than ...L proteins would not come from cell ...with S promoter deletion were shown to secrete viral particles by immunoprecipitation and ... See full document
10
Role of Transmembrane Domains of Hepatitis B Virus Small Surface Proteins in Subviral-Particle Biogenesis
... of S, variant H, that carries 11 additional amino acids at the C terminus ...to S with respect to SVP formation and release (com- pare, ...wild-type S protein on Western blots in cotrans- fection ... See full document
6
Phenotypic mixing of rodent but not avian hepadnavirus surface proteins into human hepatitis B virus particles.
... of hepatitis B virion surface proteins by ho- mologous proteins from WHV but not ...of hepatitis B virions requires the participation of SHBs and LHBs but not MHBs protein ... See full document
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Expression of the Human Hepatitis B Virus Large Surface Antigen Gene in Transgenic Tomato Plants
... HBV large surface antigen gene PRS-S1S2S. The orig- inal HBV large surface antigen gene was synthesized based on the sequence of GenBank accession ...protein S (PR-S) ... See full document
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The emerging role of hepatitis B virus Pre-S2 deletion mutant proteins in HBV tumorigenesis
... nodules containing type II GGHs, we are surprised to find that type II GGHs consist- ently harbored pre-S2 mutants with in-frame deletions over the pre-S2 regions (predominantly, ...middle ... See full document
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Role of the Pre-S2 Domain of the Large Envelope Protein in Hepatitis B Virus Assembly and Infectivity
... the pre-S domain of the L protein must be in- volved in contacts between the virus and the host cell (16, ...the surface of virions is a necessary condition to preserve the infectious ability ... See full document
6
Use of Pre-S Protein-Containing Hepatitis B Virus Surface Antigens and a Powerful Adjuvant To Develop an Immune Therapy for Chronic Hepatitis B Virus Infection
... Antibody titers were determined by using commercial enzyme-linked immunosorbent assay (ELISA) kits (ETI-AB-AUK-3; Diasorin, Italy) and were expressed in milli-international units (mIU) per milliliter, according to the ... See full document
8
Fine Mapping of Pre-S Sequence Requirements for Hepatitis B Virus Large Envelope Protein-Mediated Receptor Interaction
... envelope proteins (34). These three envelope proteins are termed large (L), middle (M), and small (S) ...outer virus shell, which is embedded in an endoplasmic reticulum (ER)-derived ... See full document
12
Inhibition of Duck Hepatitis B Virus Infection by a Myristoylated Pre-S Peptide of the Large Viral Surface Protein
... with DHBV (14 h; multiplicity of infection, ⬇75). Seven days later intracellular viral DNA was extracted, analyzed by dot blotting. and quantified with a PhosphorImager. Values are given as percentages of the value for ... See full document
5
Functions of the internal pre-S domain of the large surface protein in hepatitis B virus particle morphogenesis.
... The large hepatitis B virus (HBV) surface protein (L) forms two isomers which display their N-terminal pre-S domain at the internal and external side of the viral ... See full document
6
A pre-S gene chip to detect pre-S deletions in hepatitis B virus large surface antigen as a predictive marker for hepatoma risk in chronic hepatitis B virus carriers
... to pre-S deletions, a number of HBV markers, such as HBV viral titers and HBeAg, are also believed to be associated with the risk of HCC in chronic HBV carriers ...viral proteins [36]. We hypothesize ... See full document
8
Formation of Vesicular Stomatitis Virus Pseudotypes Bearing Surface Proteins of Hepatitis B Virus
... The virus was allowed to adsorb for ...1.0 s and centrifuged to collect the ...⫹ S), VSV ⌬ G*(HBs/L ⫹ S), and VSV ⌬ G*(HBs/L ⫹ M ⫹ S) sam- ples were similarly prepared after ... See full document
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