[PDF] Top 20 LIN28: roles and regulation in development and beyond
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LIN28: roles and regulation in development and beyond
... two Lin28 paralogs in all vertebrates: Lin28a and Lin28b (Fig. 1). All LIN28 proteins can be identified by their unique pairing of a cold shock domain (CSD) and a cysteine cysteine histidine cysteine (CCHC) ... See full document
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Lin28 promotes the proliferative capacity of neural progenitor cells in brain development
... The loss-of-function studies above suggest that Lin28a/b are required for NPC proliferation and brain development. We next performed Lin28a gain-of-function studies. We created an inducible Lin28a transgenic mouse ... See full document
12
Regulation of cell adhesion and migration in lens development
... Another potential regulator of lens cell migration is Cdk5, a proline-directed serine/threonine kinase structurally related to the cyclin-dependent kinases (Meyerson et al. , 1992). Like many proteins involved in ... See full document
9
Signaling circuitries in development: insights from the retinal determination gene network
... eye development, insight into its function and into its interactions with developmentally important signaling pathways has been gained from the comparative study of different organs and ...gonad ... See full document
11
Pocket proteins and cell cycle regulation in inner ear development
... in development have been studied through numerous cellular and biochemical analyses as well as studies of genetically engineered null mutant ...during development (Table ...overlapping roles as ... See full document
12
Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring
... regulatory roles in important biological processes such as X-chromosome inactivation in females, silencing of tumor suppressor genes, mediation of DNA damage and cellular stress re- sponses, gene imprinting, ... See full document
27
Pathways that regulate renal development, fibrosis, and metabolic disease in mouse models
... Obesity is a considerable public health problem that affects a sizeable part of the world population across all age and racial/ethnic groups. Obesity is a worldwide epidemic that predisposes individuals to ... See full document
82
p53: emerging roles in stem cells, development and beyond
... metabolic regulation and other responses that promote the repair and survival or death and elimination of abnormal cells (Vousden and Prives, ...modulatory roles played by other p53 family members, p63 and ... See full document
10
Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development
... gene regulation by epigenetic ...epigenetic regulation in mammalian development, we examined one of these six, Mll2, using a multipurpose allele in the mouse to ascertain the loss-of-function ... See full document
10
Origins and plasticity of neural crest cells and their roles in jaw and craniofacial evolution
... Recently there have been significant advances in our under- standing of craniofacial patterning through neural crest cell trans- positions within the hindbrains of mouse (Golding, et al., 2000; Trainor and Krumlauf, ... See full document
13
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
... the regulation of transcription and this was exemplified in the development of the retina, where cyclin D1 associates with the upstream regulatory element of the Notch1 ... See full document
15
Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia
... gene regulation in MLL-FPs cells (Figure 3A, 3C and Supplemental Figure ...BRD4 regulation of c-Myc [29-31] and other factors such as Myb and Ets proteins [32, ... See full document
16
Transcriptional regulation of cadherins during development and carcinogenesis
... Based on the available information we propose a model for the participation of the different E-cadherin repressors in tumour invasion (Fig. 4). Thus, the transient expression of Snail, or SIP1, will be involved in ... See full document
11
Beyond solidarity and academic freedom
... Luther Blissett: The present period of capitalism seems to be typified by pervasive neoliberal attacks on any sectors which appear decommodified or are not fully integrated into capitalism. In many ways this is a ... See full document
9
Regulation and expression of elrD1 and elrD2 transcripts during early Xenopus laevis development
... the development and maintenance of neurons. The regulation of elrD gene expression involves two promoters, pD1 and ...developmental regulation. Our results show a complex regulation of the ... See full document
6
An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates
... of Lin28 to the mutant pre-let-7g sequence ...3. Lin28 binding correlates with NMM ...the Lin28 interaction with wild-type and mutant let-7g loop (B–D) and full-length and truncated HSAP5 LRE ... See full document
16
Card Sorting: Current Practices and Beyond
... The ability to analyze card sorting data is a “touchy-feely” qualitative experience that can’t be described beyond “eyeballing” and “looking for trends.” Eyeballing the data is very tedious, time-consuming, and ... See full document
6
Auto regulation of thyroid hormone receptor genes during metamorphosis: roles in apoptosis and cell proliferation
... Int I De, BioI ~2 107 116 (1998) 107 Auto regulation of thyroid hormone receptor genes during metamorphosis roles in apoptosis and cell proliferation YUN BO SHI+, YUAN SU, QING U and SASHKO DAMJANOVSK[.] ... See full document
10
Beyond the MDGS: Inclusion, participation and the reality of gender development in Sub Saharan Africa (SSA)
... and development (GAD) planning in the developing world (Razavi and Miller, 1995), suggested that it must be based on interests – which was defined as a ‘prioritized concern’ that translates into women’s ... See full document
7
Brands beyond good and evil?
... Brands are about a form of life, a way of living: brands express the quest for the self-actualization and lifestyle reveals the ‘truth’ of the individual.. Consequently, brands start [r] ... See full document
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