[PDF] Top 20 Long non-coding rnas – “tuning fork” in regulation of cell processes

... (long non-coding RNA; lncRNA), выступают в роли сигнальных молекул, навигационных систем и платформ для cборки сложных рибонуклеиновых ком- плексов; участвуют в организации специальных клеточных ... See full document

... cellular processes, in- cluding regulation of gene expression at the transcrip- tional [9–11] and post transcriptional levels ...of non-coding RNAs and human diseases are available such ... See full document

... There are CpG islands in the upstream region of the miR-375 gene and aberrant DNA methylation in this gene can be observed in specific melanoma stage [115,116]. His- tone modification of DNA methylation is one vital ... See full document

... In order to confirm aberrant lncRNA expression, we de- termined the expression of 13 lncRNAs in an independent validation cohort of ccRCC (n = 55) and normal (n = 52) renal tissue samples. The selection of representative ... See full document

... the regulation of alternative splicing and cell cycle has been proposed for this lncRNA ...involving cell cycle regulation, p53-mediated DNA damage response, and mRNA maturation ... See full document

... from cell to ...other cell types like muscle ...of cell shape and its relation to the function of the neuron (Cajal, ...main cell body or soma of the neuron contains the nucleus and is also a ... See full document

... cancer cell invasiveness ...in non-malignant ...clear cell) as well as fallopian tube and non-classifiable tumors, which could possibly explain this ...A2780cisR cell line, a ... See full document

... a long intervening non-coding RNA (lincRNA) transcribed from the HOXC locus, which participates in epigenetic regulatory processes, cooperates with polycomb repressive complex 2 and is ... See full document

... post-transcriptional processes (Hata et ...enhanced cell survival and proliferation and conversely, breast cancer patients with increased NEAT1 expression show poor survival (Choudhry et ... See full document

... Non-coding RNAs are important regulators of gene expression and ...impaired non-coding RNA expression especially the one of long non-coding RNAs and ... See full document

... therapy. Long non-coding RNAs (lncRNAs) are involved in cancer development and progression by the regulation of processes related to chromatin remodeling, transcription, and ... See full document

... Long non-coding RNAs (lncRNAs) are increasingly implicated as gene regulators in diverse ...squamous cell carcinoma ...the regulation of lung adenocarcinoma ... See full document

... regulatory RNAs or proteins to attenu- ate regulation; the guide archetype, which directs the localization of chromatin-modifying complex (es) and other nuclear protein (s) to specific targets to exert ... See full document

... DOI: 10.4236/ojog.2018.82017 137 Open Journal of Obstetrics and Gynecology lncRNA located in the 8q24 chromosomal region of the human genome which is also the commonest sites of cancer-related amplifications containing ... See full document

... cancer cell migration and invasion by down-regulating H19 via DNA methylation ...let-7-mediated regulation of metastasis-promoting genes, including Hmga2, c-Myc and Igf2bp3 ...carcinoma cell lines ... See full document

... called long ncRNA (lncRNA). Several house-keeping non-coding transcripts like the rRNAs, tRNAs, snRNAs, snoRNAs etc have been recognized for long to have essential roles in translation of ... See full document

... tissue-, cell-, and develop- mental stage-specific expression and are differently expressed under physiological or pathological conditions, which indicate that these transcripts can be ...This regulation of ... See full document

... Non-coding RNAs (ncRNA) are implicated in several epigenetic processes, notably small RNAs that can influence histone modifications and cytosine methylation which are connected with ... See full document

... 2 cell lineage-specifying transcription factors T-bet and Gata3, respectively [165, ...T cell differentiation path is determined not simply by the epigenetic states of cytokine gene loci but also the epige- ... See full document

... of coding and non-coding genetic sequences such as statistical features of nucleotides of the molecular ...While coding DNA is predominantly short-range correlated, the order in ... See full document