[PDF] Top 20 Memory CD4+ T cells do not induce graft versus host disease
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Memory CD4+ T cells do not induce graft versus host disease
... of T cell–depleted allo- grafts as compared with recipients of T cell–replete ...donor T cells from EBV-immune donors induce regressions of PTLDs ...donor T cells specific ... See full document
9
BATF dependent IL 7RhiGM CSF+ T cells control intestinal graft versus host disease
... Acute graft-versus-host disease (GVHD) represents a severe, T cell–driven inflammatory complication following allogeneic hematopoietic cell transplantation ...BATF-expressing T ... See full document
16
Human LAP+GARP+FOXP3+ regulatory T cells attenuate xenogeneic graft versus host disease
... of cells, animals were monitored twice a week for weight loss and other signs of xGVHD, ...human graft-related disease if an expanded population of human cells was detected simultaneously in ... See full document
10
Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease
... Isolation of intestinal cells. Single-cell suspensions were prepared from intestines as described previously (20). Briefly, intestines were flushed with PBS to remove fecal matter and mucus. Fragments (<0.5 cm) ... See full document
15
T-cell suicide gene therapy in the management of graft versus host disease following allogeneic bone marrow transplatation
... transduced cells to be rapidly identified and there was no evidence that eGFP mediated any toxic effects as suggested in some reports (Liu et al, ...transduced cells on the basis of eGFP expression using ... See full document
203
Original Article Effects of regulatory dendritic cells on graft-versus-host disease and graft-versus-leukemia in mice after allogeneic bone marrow transplantation
... specific t (6; 11) (q27; q23) chromo- somal abnormality and MLL/AF6 fusion tran- script [15], was kindly provided by the Institute of Hematology of Jiangsu ...SHI-1 cells were taken from liquid nitrogen ... See full document
11
The influence of regulatory T cells and mobilisation regimens on graft versus malignancy, graft versus host disease and relapse in haematopoietic progenitor cell transplantation
... auto-reactive T cells and the elimination of the peripheral immuno-regulatory system by the preparative regimen providing a permissive environment for the auto-reactive T cells (Hess, ...the ... See full document
181
Intestinal graft versus host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes
... treatment of the donor cell inoculum. However, neither anti-Lyt2 + C, Leu-Leu-OMe, nor anti- Lyt2 + C and Leu-Leu-OMe treatment of donor cells significantly decreased severity of gut GVHD. Leu-Leu-OMe treatment of ... See full document
11
Preterminal host dendritic cells in irradiated mice prime CD8+ T cell–mediated acute graft versus host disease
... of host DCs during the first few days following TBI was surprising, since acute GVHD was not clinically and pathologically detected in the recipients until 1–2 weeks after allo-BMT (Figure ...naive T ... See full document
11
Programmed death ligand 1 expression on donor T cells drives graft versus host disease lethality
... “exhausted” T cells to regain normal functional capacities, secrete proinflam- matory cytokines, and support productive immune responses ...on T cells and experiments using blocking Abs or ... See full document
20
A comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated donors in acute leukemia
... GRFS: Graft-versus-host relapse-free survival; GVHD: Graft-versus-host disease (acute aGvHD or chronic cGvHD); HAPLO: Haploidentical donor; LFS: Leukemia-free survival; ... See full document
8
Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell–mediated graft versus host disease model
... vigorous T cell response can rapidly generate high levels of proinflammatory cytokines responsible for initiating acute tissue damage in the early post-HCT ...by host nonhematopoietic target tissues in the ... See full document
8
Peripheral tissues reprogram CD8+ T cells for pathogenicity during graft-versus-host disease
... SLOs versus GVHD target organs compared, we initially evaluated the expres- sion of cytotoxic and cytokine molecules known to be important in T E ...gut T E , whereas a subset of proinflammatory ... See full document
20
Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease
... of T cells, MSCs inhibit the proliferation and activation of T cells, and downregulate the secretion of inflamma- tory factors (such as IL-2, TNF-α, ...conventional T cells may ... See full document
11
Mesenchymal stromal cells for the prophylaxis and treatment of graft-versus-host disease—a meta-analysis
... stromal cells (MSC) for either the prevention or the treat- ment of GvHD for patients who undergo ...to induce a shift from a pro- to an anti- inflammatory environment [20] makes them suitable to treat ... See full document
12
Granulocyte colony stimulating factor affects the distribution and clonality of TRGV and TRDV repertoire of T cells and graft versus host disease
... oligoclonal T cell expan- sion could be incurred due to many factors affecting the overall regulation of clone size in response to chronic antigens ...6 T cells appeared in two patients with aGVHD, ... See full document
9
Hepatocyte growth factor prevents lupus nephritis in a murine lupus model of chronic graft versus host disease
... of host DCs following bone marrow trans- plantation is correlated with the development of severe acute and chronic GVHD ...with T cells, deliver a signal that results in T cell deletion and ... See full document
9
Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft versus host disease in mice
... Because cells were studied on day 3 of culture, we pos- tulate that Stat1 expression was already completely downregulated and that IFN-γ may promote Stat1 gene transcription through the MAPK pathway ... See full document
17
Original Article A tolerogenic peptide hCDR1 aggravates lupus in chronic graft-versus-host model of systemic lupus erythematosus
... chronic graft versus host disease (cGVHD) mouse ...the disease progression in SLE-cGVHD ...lupus-like disease manifested by earlier onset of proteinuria, elevated serum levels of ... See full document
12
A possible role of low regulatory T cells in anti-acetylcholine receptor antibody positive myasthenia gravis after bone marrow transplantation
... 4. Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, et al. National Institutes of Health consensus development project on criteria for clinical trials in ... See full document
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