[PDF] Top 20 Memory CD4+ T-Lymphocyte Loss and Dysfunction during Primary Simian Immunodeficiency Virus Infection
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Memory CD4+ T-Lymphocyte Loss and Dysfunction during Primary Simian Immunodeficiency Virus Infection
... the loss of CD4 ⫹ T-lymphocyte function during the period of primary infection, we characterized the functional capacity of the residual memory CD4 ⫹ ... See full document
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Identifying the Target Cell in Primary Simian Immunodeficiency Virus (SIV) Infection: Highly Activated Memory CD4+ T Cells Are Rapidly Eliminated in Early SIV Infection In Vivo
... cells were light blue. Positive (brown) cells were then counted using an Olympus Vanox-S microscope interfaced to a Quantimet 570C image analysis system (Leica, Cambridge, Mass.). First, a detection threshold that would ... See full document
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Divergent Kinetics of Proliferating T Cell Subsets in Simian Immunodeficiency Virus (SIV) Infection: SIV Eliminates the “First Responder” CD4+ T Cells in Primary Infection
... including during very early (acute) infection at 8 (n ⫽ 6), 10 (n ⫽ 4), 13 (n ⫽ 5), and 21 (n ⫽ 2) days postinoculation (dpi) or during chronic infection (defined here as infection over ... See full document
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Dynamic Modulation of Expression of Lentiviral Restriction Factors in Primary CD4+ T Cells following Simian Immunodeficiency Virus Infection
... by memory subset (Fig. 1E). Since each memory subset was more similar to the respective subset from another animal rather than other subsets from the same animal ...to memory subset ... See full document
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Simian Immunodeficiency Virus Infects Functionally Polarized Memory CD4 T Cells Equivalently In Vivo
... of infection, CD4 T cell reconstitution in the GI tract is inefficient, Th17 cell perturbations remain, and residual microbial translocation and inflammation ...preferential loss of Th17 cells ... See full document
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Loss of Naïve Cells Accompanies Memory CD4+ T-Cell Depletion during Long-Term Progression to AIDS in Simian Immunodeficiency Virus-Infected Macaques
... in memory CD4 ⫹ T-cell turnover was observed in most of the SIV-infected IP and CP cohort by week 4 ...circulating memory cell population during the acute infection ...and ... See full document
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Reduced Protection from Simian Immunodeficiency Virus SIVmac251 Infection Afforded by Memory CD8+ T Cells Induced by Vaccination during CD4+ T-Cell Deficiency
... ⫹ T cells at the portal of entry in order to prevent CD4 ⫹ T-cell loss during acute ...⫹ T-cell re- sponse occurs ...while T-cell vaccines induce T-cell responses ... See full document
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Long-Term Control of Simian Immunodeficiency Virus Replication with Central Memory CD4+ T-Cell Preservation after Nonsterile Protection by a Cytotoxic T-Lymphocyte-Based Vaccine
... of virus-specific CD8 ⴙ cytotoxic T-lymphocyte (CTL) responses is a promising strategy for AIDS vaccine ...of simian immunodeficiency virus (SIV) mac239 replication without ... See full document
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FoxP3+ CD25+ CD8+ T-Cell Induction during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques Correlates with Low CD4+ T-Cell Activation and High Viral Load
... load during primary infection and to improve control over viremia in the long term ...study, during chronic infection, 128 to 274 days after infection, viral load as a function ... See full document
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Memory CD4+ T Lymphocytes in the Gastrointestinal Tract Are a Major Source of Cell-Associated Simian Immunodeficiency Virus in Chronic Nonpathogenic Infection of African Green Monkeys
... cell-associated virus pools in natural SIV hosts, we investigated the T-cell-associated virus population in multiple tissue compartments of sabeus African green monkeys (AGMs) who were intravenously ... See full document
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Dynamics of T- and B-Lymphocyte Turnover in a Natural Host of Simian Immunodeficiency Virus
... and memory CD4 ⫹ T-lymphocyte subsets in sooty ...⫺ memory population and a short-lived CD45RA ⫹ memory population of peripheral blood CD4 ⫹ T lymphocytes were ...⫹ ... See full document
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Gag-Specific Cytotoxic T-Lymphocyte-Based Control of Primary Simian Immunodeficiency Virus Replication in a Vaccine Trial
... viral infection and AIDS progression ...a loss of viral fitness may revert to the wild-type sequence after transmission into MHC- I-mismatched hosts (4, 8, 9, 16, 18, 20), but such reversion does not occur ... See full document
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Increased Loss of CCR5+ CD45RA− CD4+ T Cells in CD8+ Lymphocyte-Depleted Simian Immunodeficiency Virus-Infected Rhesus Monkeys
... Confocal microscopy. Tissue sections were stained for viral SIV RNA as outlined above with the following modifications. All samples were treated with a methonolic-hydrogen peroxide solution to quench endogenous ... See full document
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Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4+ T Cells
... emerging virus-specific cytotoxic T-lymphocyte (CTL) responses during PHI have been associated with the decrease in the HIV-1 viral load and the establishment of a set point of viral ... See full document
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Polyfunctional CD4+ T-Cell Induction in Neutralizing Antibody-Triggered Control of Simian Immunodeficiency Virus Infection
... of memory CD4 ⴙ T cells and delayed induction of neutralizing antibody (NAb) responses are characteristics of human immunodeficiency virus (HIV) and simian ... See full document
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Infection of CD127+ (Interleukin-7 Receptor+) CD4+ Cells and Overexpression of CTLA-4 Are Linked to Loss of Antigen-Specific CD4 T Cells during Primary Human Immunodeficiency Virus Type 1 Infection
... purified CD4 ⴙ T-cell ...of infection of CCR5 ⫹ CD38 ⫹⫹⫹ CD4 ⫹ T cells during PHI ...lost during PBMC isola- tion and cryopreservation ...on CD4 ⫹ T cells ... See full document
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Impact of Cytotoxic-T-Lymphocyte Memory Induction without Virus-Specific CD4+ T-Cell Help on Control of a Simian Immunodeficiency Virus Challenge in Rhesus Macaques
... eliciting virus-specific T-cell responses, whether induction of these memory T cells by vaccination before human immunodeficiency virus (HIV) exposure can actually contribute to ... See full document
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Dynamics of CCR5 Expression by CD4+ T Cells in Lymphoid Tissues during Simian Immunodeficiency Virus Infection
... SIV infection explained why only certain cells could be in- fected with ...the CD4 molecule, HIV and SIV require one or more chemo- kine receptors as coreceptors for attachment and entry into host ...most ... See full document
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Differential CD4+ T-Lymphocyte Apoptosis and Bystander T-Cell Activation in Rhesus Macaques and Sooty Mangabeys during Acute Simian Immunodeficiency Virus Infection
... of CD4 ⫹ T-lymphocyte activation and apoptosis in SM during acute SIV infection could be due to the presence of fewer productively infected CD4 ⫹ T lymphocytes, resulting ... See full document
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Antiviral Therapy during Primary Simian Immunodeficiency Virus Infection Fails To Prevent Acute Loss of CD4+ T Cells in Gut Mucosa but Enhances Their Rapid Restoration through Central Memory T Cells
... Viral infection and sample ...5; primary treatment group) or 10 weeks of postin- fection (n ⫽ 5; chronic treatment group) and continued for 30 weeks ...(APC)-Cy7, CD4 (OKT4)- Pacific Blue, CD8 ... See full document
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