[PDF] Top 20 Microvascular dysfunction and the development of muscle insulin resistance
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Microvascular dysfunction and the development of muscle insulin resistance
... the insulin-sensitising effect of ACE inhibition in muscle can be largely attributed to enhancement of bradykinin, which in turn can increase GLUT-4 translocation and thus augment insulin-mediated ... See full document
236
Role of the microvasculature in the development of muscle insulin resistance
... The physiology of the microvascular recruitment process was further assessed by Zhang and colleagues Zhang 2004 where they found a dose-dependent effect of insulin infusion on capillary [r] ... See full document
192
Comparison of cerebral and cutaneous microvascular dysfunction with the development of type 1 diabetes
... Vascular hemoglobin, as the principal carrier of oxygen, is related to the vascular blood oxygen response. In persistent hyperglycemia, glycated hemoglobin will also be maintained at a high level, and this can affect the ... See full document
15
Ablation of AMP-Activated Protein Kinase \(\alpha\)2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice
... skeletal muscle AMPK ␣ 2 activity exacerbates the development of glucose ...isolated muscle. We next exam- ined muscle insulin sensitivity for glucose transport using the in vitro ... See full document
10
Year in review 2010: Critical Care cardiology
... Microcirculatory dysfunction is now recognized as potentially contributing to sepsis-associated organ dys- func tion ...the development of microvascular dysfunction in sepsis, Doerschug and ... See full document
7
MondoA drives muscle lipid accumulation and insulin resistance
... Obesity-related insulin resistance is strongly associated with intracellular neutral lipid accumulation in extra-ad- ipose tissues, such as skeletal muscle and liver ...in muscle given the ... See full document
17
Glucose toxicity and the development of diabetes in mice with muscle specific inactivation of GLUT4
... selective muscle insulin resist- ance, we also observed a significant decrease in insulin-stimulated glucose uptake in white and brown adipose tissue, as well as hepatic insulin resist- ance ... See full document
9
The role of adipokines in skeletal muscle inflammation and insulin sensitivity
... the development of insulin ...increased insulin resistance in LDL- receptor deficient mice fed a high fat diet, as evidenced by reduced insulin-mediated AKT phosphorylation ...skeletal ... See full document
11
Myocardial insulin resistance does not always parallel skeletal muscle and whole body insulin resistance: A mini review—Myocardial Insulin Resistance
... heart muscle glucose utilization in patients with T2DM without CAD could not be improved within 12 weeks by an acute use of troglitazone ...skeletal muscle insulin resis- tance over 12 months’ ... See full document
5
Inactivation of fatty acid transport protein 1 prevents fat induced insulin resistance in skeletal muscle
... in insulin signaling activities and insulin action in skeletal ...skeletal muscle, and they are the first demonstration of a role of FATP1 on fatty acid metabolism and glucose homeostasis in ... See full document
9
Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside
... This study demonstrated that AICAR treatment had two potential detrimental actions in vivo. Firstly, AICAR treatment increased lactate production in resting mus- cle. This finding is in agreement with other reports which ... See full document
12
Reduced mitochondrial density and increased IRS 1 serine phosphorylation in muscle of insulin resistant offspring of type 2 diabetic parents
... mitochondrial dysfunction and insulin resistance that occur in the mus- cle of young, lean, normoglycemic, insulin-resistant offspring of parents with type 2 diabetes (IR offspring), we ... See full document
8
Free fatty acid can induce cardiac dysfunction and alter insulin signaling pathways in the heart
... in insulin-resistant states ...duce insulin resistance by inhibiting glucose uptake in skeletal muscle, hepatocytes, and adipocytes, and by at- tenuating insulin signaling in ... See full document
8
Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV 1–infected patients with lipodystrophy
... Mitochondrial dysfunction and impaired oxida- tive capacity (especially in skeletal muscle) caused by nucleoside-analogue reverse transcriptase inhibitors (NRTIs) are well-known side effects of ... See full document
10
Higher cardiometabolic risk in idiopathic versus autoimmune type 1 diabetes: a retrospective analysis
... leptin resistance and low-grade inflammation, which are all alterations present in a state of adipose tissue dys- ...with insulin resistance [39], resistin, a potential mediator of obesity related ... See full document
8
Skeletal muscle inflammation and insulin resistance in obesity
... obesity development (35, 53, 56, 57, 60). Macrophage infiltration precedes T cell infiltration (35). Infiltration of leukocytes from the circulation into tissues requires attractant signals such as chemo- kines, ... See full document
13
<p>The relationship of mitochondrial dysfunction and the development of insulin resistance in Cushing’s syndrome</p>
... Results: Patients with active Cushing ’ s syndrome had signi fi cantly increased body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and serum lipids relative to the control ... See full document
13
Mitochondrial dysfunction in patients with primary congenital insulin resistance
... whether insulin resistance and/or mitochondrial dysfunction might alter metabolic rate, we evaluated basal metabolic rate (BMR) and sleeping metabolic rate (SMR) in our patients with INSR mutations ... See full document
6
Endothelial dysfunction: Mechanisms and reversal in insulin resistance and diabetes mellitus
... endothelial dysfunction, either as a protective response or an abnormal reaction, and is thought to be a key event in the initiation of ...The development of a non- invasive method, which uses ... See full document
258
Effect of green tea polyphenol, EGCG, on insulin sensitivity
... Insulin resistance contributes to and precedes the development of type 2 ...diabetes. Insulin-stimulated microvascular perfusion and glucose uptake in skeletal muscle are ... See full document
226
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