[PDF] Top 20 Modifications to the Foot-and-Mouth Disease Virus 2A Peptide: Influence on Polyprotein Processing and Virus Replication
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Modifications to the Foot-and-Mouth Disease Virus 2A Peptide: Influence on Polyprotein Processing and Virus Replication
... the 2A/2B junction is required for optimal virus ...IMPORTANCE Foot-and-mouth disease virus (FMDV) causes one of the most economi- cally important diseases of farm ...the ... See full document
16
Synthetic and structural studies of foot and mouth disease virus polyprotein processing
... Two-dimensional NMR spectroscopy provides an important tool for identifying preferred conformers in otherwise unstructured p e p t i d e s . This stems from its usefulness in detecting highly localized conformations that ... See full document
197
Employing transposon mutagenesis to investigate foot-and-mouth disease virus replication
... the foot-and-mouth disease virus (FMDV) RNA replication complex has been restricted in part by the lack of suitable ...for virus replication as well as locations that can ... See full document
12
Foot and mouth disease virus: A review
... The replication of non-structural proteins is encoded by the domains of P2 and ...the polyprotein to be immediately ...the polyprotein into many precursor and mature proteins, which produce ... See full document
9
Foot-and-Mouth Disease Virus Nonstructural Protein 2C Interacts with Beclin1, Modulating Virus Replication
... Foot-and-mouth disease virus (FMDV), the causative agent of foot-and-mouth disease, is an Apthovirus within the Picornaviri- dae ...family. Replication of the ... See full document
11
Optimisation of the foot and mouth disease virus 2A co expression system for biomedical applications
... Various conventional approaches for protein co- expression have been utilized such as the use of multiple internal promoters, internal ribosome entry sites (IRESes), messenger RNA splicing, fusion proteins, and post- ... See full document
11
Development of a foot and mouth disease virus replicon system for the study of RNA replication
... pBEV 2A replicon suggests that translation is able to occur as usual, but incomplete processing is rendering important proteins such as 2B from performing their critical role during replication: ... See full document
201
The foot-and-mouth disease virus leader proteinase gene is not required for viral replication.
... viable virus, but cells transfected with RNAs that utilized the second AUG to drive translation of the viral polyprotein produced viable ...(WT) virus, grew to slightly lower titers than WT ... See full document
7
Foot-and-mouth disease virus capsid assembly
... the virus polyprotein ...affect processing of the other junctions ...that modifications that modify or delete a short motif in the C-terminus of VP1, can prevent processing of the FMDV ... See full document
161
The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication
... FMDV replication when added up to 3 h post-transfection of FMDV RNA repli- cons, and ARB does not inhibit cellular or IRES-mediated translation, it is not likely to inhibit early replication events, such as ... See full document
10
The broad spectrum antiviral drug arbidol inhibits foot and mouth disease virus genome replication
... FMDV replication when added up to 3 h post-transfection of FMDV RNA repli- cons, and ARB does not inhibit cellular or IRES-mediated translation, it is not likely to inhibit early replication events, such as ... See full document
10
Role of RNA Structure and RNA Binding Activity of Foot-and-Mouth Disease Virus 3C Protein in VPg Uridylylation and Virus Replication
... VPg peptide primer is the first stage in the replication of picornavirus ...the foot-and-mouth disease virus (FMDV) 5 ⴕ untranslated region but outside of the cre/bus can enhance ... See full document
11
Processing of the VP1/2A Junction Is Not Necessary for Production of Foot-and-Mouth Disease Virus Empty Capsids and Infectious Viruses: Characterization of “Self-Tagged” Particles
... The foot-and-mouth disease virus (FMDV) capsid protein precursor, P1-2A, is cleaved by 3C pro to generate VP0, VP3, VP1, and the peptide ...the 2A peptide from the ... See full document
13
Genetic Economy in Picornaviruses: Foot-and-Mouth Disease Virus Replication Exploits Alternative Precursor Cleavage Pathways
... and processing intermediates have evolved to perform distinct ...Uniquely, foot-and-mouth disease virus (FMDV) encodes three similar copies of 3B (3B1-3), thus providing a convenient ... See full document
25
Multiple proteases in foot-and-mouth disease virus replication.
... It has been shown that the protease required for cleavage of the precursor into the mature structural proteins is coded for by a portion of the RNA near the 3' end of the genome (17).. T[r] ... See full document
6
How foot and mouth disease virus receptor mediates foot and mouth disease virus infection
... Conclusions Receptors are the major determinant factors for the tropism and pathogenesis of viruses. Viruses may utilize different receptors at the different stage of viral patho- genesis. FMDV is the only virus ... See full document
7
Employing transposon mutagenesis to investigate foot and mouth disease virus replication
... w t R e p - T n lib r a r y 3 D p o l Figure S1. Replication of the transposon-mutated replicon library. BHK-21 cells seeded into 12-well plates were allowed to adhere for 16 hours before transfection with ... See full document
33
Processing of rabbit hemorrhagic disease virus polyprotein.
... proteolytic processing of the polypeptide products of clones pRC49 and pRC30 demonstrates that these large regions of the RHDV polyprotein do not code for viral proteases capable of autocatalytic ... See full document
5
Foot-and-mouth disease virus and poliovirus particles contain proteins of the replication complex.
... Nonstructural proteins 2C, 3CD, 3C, and 3D, and the cellular protein actin, are present in highly purified preparations of foot-and-mouth disease virus (FMDV) and poliovirus. They remain bound ... See full document
6
Comparative Genomics of Foot-and-Mouth Disease Virus
... of foot-and- mouth disease virus (FMDV) representing all seven serotypes and including the first complete sequences of the SAT1 and SAT3 ...SAT virus lineage containing nonstructural ... See full document
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