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[PDF] Top 20 Multi tissue DNA methylation age predictor in mouse

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Multi tissue DNA methylation age predictor in mouse

Multi tissue DNA methylation age predictor in mouse

... average methylation levels were slightly higher (~45%) but did not show major dif- ferences between ages or tissues (Additional file ...Global methylation levels measured by RRBS are generally lower than ... See full document

14

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

... Horvath’s age predictor [24] (Additional file 7: ...Horvath’s age predictor was trained using a penal- ized regression method aimed at identifying a sparse set of independent predictors and ... See full document

11

Original Article Tissue-specific differential DNA methylation at Igf2/H19 locus in a mouse model for embryonal ethanol exposure

Original Article Tissue-specific differential DNA methylation at Igf2/H19 locus in a mouse model for embryonal ethanol exposure

... Fudan University. Mice were kept on a 12-hour light/dark cycle and were given free access to food and water at a constant room tempera- ture. Then, 8-10 week-old female mice were naturally mated with same-aged male mice. ... See full document

10

Extensive epigenetic reprogramming during the life cycle of Marchantia polymorpha

Extensive epigenetic reprogramming during the life cycle of Marchantia polymorpha

... differential methylation, we only used cytosines that were sequenced in at least two out of three replicates across all tissue types (1,005,661 in total, 994,696 without X and Y chromosome scaffolds, which ... See full document

17

Novel regional age associated DNA methylation changes within human common disease associated loci

Novel regional age associated DNA methylation changes within human common disease associated loci

... regions Age-related DNA methylation changes within GWAS disease-associated regions where blood tissue may be directly involved in the pathophysiology make strong candidates for an epigenetic ... See full document

14

Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age

Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age

... Komen Tissue Bank is well-equipped to accurately clas- sify a subject’s age, while other cancer risk factors such as average alcohol consumption may be impacted by re- call ...between age ... See full document

11

DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics

DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics

... by age and sex such that in early childhood males are more likely to have asthma symptoms than females, while this relationship seems to reverse in adolescents resulting in more female adult asthma ...mean ... See full document

9

DNA methylation reprogramming and DNA repair in the mouse zygote

DNA methylation reprogramming and DNA repair in the mouse zygote

... and DNA modifications (Jenuwein and Allis, 2001; Kouzarides, ...genomic DNA, which itself is also specifically modified by methylation and hydroxymethylation at cytosine residues, allows the ... See full document

10

DNA methylation age is not affected in psoriatic skin tissue

DNA methylation age is not affected in psoriatic skin tissue

... the multi-tissue DNAm age clock developed by Horvath [18, ...this age predictor on our methylation ...DNAm age and chronological age for both NN and PN ...the ... See full document

7

A multi-tissue age prediction model based on DNA methylation analysis

A multi-tissue age prediction model based on DNA methylation analysis

... overall multi-tissue accuracy rate based on bootstrap analysis is ...predicted age is ...same tissue types, and within the age range of those samples used to train the ... See full document

5

DNA methylation and transcriptional noise

DNA methylation and transcriptional noise

... of DNA methylation are more likely to adopt and maintain a permissive transcriptional state (similar to the ‘ON’ state referred to above) and exhibit lit- tle transcriptional ...to DNA ... See full document

10

Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing

Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing

... digital methylation analysis (Figure ...and mouse methylation standards at mixed ratios (0, 5, 10, 25, 50, 75 and 100%) were ana- lyzed for CpG methylation levels using BSAS (Figure 1) as well ... See full document

12

Intergenerational genomic DNA methylation patterns in mouse hybrid strains

Intergenerational genomic DNA methylation patterns in mouse hybrid strains

... in methylation between the two alleles was at least 50%, and where the AMR was defined by at least 10 consecutive ...allele-specific methylation that is dependent on the genotype of the DNA strand, ... See full document

13

Age-associated decrease in global DNA methylation in patients with major depression

Age-associated decrease in global DNA methylation in patients with major depression

... as age, illness duration, illness onset, education, body mass index (BMI), HAM-D scores, chlorpromazine equivalents, and imipramine equivalents, by the Pearson correlation ... See full document

10

Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C

Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C

... unique methylation epi-signature has been reported for Sotos syndrome, caused by mutations in the NSD1 gene, which encodes histone H3 lysine 36 methyltransferase ...the DNA methylation epi-signature ... See full document

11

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

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... the methylation status of the specific sites which range from primitive cumbersome manual techniques to high throughput automated assays [3], [4], [5] and ...genomic DNA, followed by alkaline treatment ... See full document

8

Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking

Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking

... on DNA methylation by comparing the genome-wide DNA methylation patterns between lung adenocarcinoma samples from six smokers and six ...smoking-induced DNA methylations were enriched ... See full document

9

Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation

Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation

... donor’s age on one side and C1orf132 methylation and lymphocyte numbers on the other side appeared independent from each other definite conclu- sions are ...C1orf132 methylation is a marker of a ... See full document

7

DNA methylation, epialleles and gene regulation: Insights from the honey bee

DNA methylation, epialleles and gene regulation: Insights from the honey bee

... differential methylation that could either intensify or weaken the transcriptional efficiency of constitutively expressed ...in DNA, but sequence variants may be necessary to ensure the high level of ... See full document

176

The SMART App: an interactive web application for comprehensive DNA methylation analysis and visualization

The SMART App: an interactive web application for comprehensive DNA methylation analysis and visualization

... The home page first displays the number of DNA meth- ylation samples available from TCGA project, colored by sample types (i.e., Normal and Tumor), for users to gain an overview of the sample size of the cancer ... See full document

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