[PDF] Top 20 A multi-tissue age prediction model based on DNA methylation analysis
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A multi-tissue age prediction model based on DNA methylation analysis
... related tissue-specific DNA methylation markers have been identified in many studies, which can be used to estimate the chronological age of an unknown biological sample’s ...of tissue, ... See full document
5
Accurate ethnicity prediction from placental DNA methylation data
... Threshold analysis for determining “ambiguous” ...a model trained to all other datasets. Figure S5. Enrichment analysis on ethnicity-predictive HM450K ... See full document
14
Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age
... 6]. DNA methylation is a stable, yet modifiable epigenetic modification and DNA methylation alterations are known to occur early in breast carcinogenesis [7, ...that DNA ... See full document
11
A deep neural network based regression model for triglyceride concentrations prediction using epigenome wide DNA methylation profiles
... the methylation level is expressed as a value between 0 and 1 in 993 partici- pants of the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) ...the model to predict posttreatment of triglyceride ... See full document
6
CancerLocator: non invasive cancer diagnosis and tissue of origin prediction using methylation profiles of cell free DNA
... used DNA methylation microarrays of solid tumor tissues to train the model due to the scar- city of whole-genome bisulfite sequencing data (WGBS) in the public ...Since DNA methylation ... See full document
12
DNA methylation data-based molecular subtype classification and prediction in patients with gastric cancer
... as DNA methylation, copy number variation, and original sequencing data, to explore precise cancer clas- sification models and Cancer occurrence and develop- ment mechanism ...classification model ... See full document
10
Genetic and Environmental Causes of Variation in the Difference Between Biological Age Based on DNA Methylation and Chronological Age for Middle-Aged Women
... biological age based on DNA methylation and chronological age ( age) has been found to have approximately 40% heritability by assuming that the familial correlation is only ... See full document
7
Association of DNA methylation with age, gender, and smoking in an Arab population
... of age [34,41]. Bocklandt et al. [40] used a regression model with just two loci that explained a large portion of the variance in age to predict the age of an individual with an accuracy of ... See full document
12
Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception
... Horvath’s age predictor [24] (Additional file 7: ...Horvath’s age predictor was trained using a penal- ized regression method aimed at identifying a sparse set of independent predictors and the fact that it ... See full document
11
Leisure-time physical activity and DNA methylation age—a twin study
... DNAm age was calculated using a validated algorithm and online tool ...is based on 353 specific CpG sites measured on the 450 BeadChip and known to associate with aging based on their DNA ... See full document
8
Measuring animal age with DNA methylation: from humans to wild animals
... are tissue specific, however several studies have investigated age-associated changes in multiple ...predict age using multiple tissues (Koch and Wagner, ...donor age resulted in a ... See full document
8
Original Article Tissue-specific differential DNA methylation at Igf2/H19 locus in a mouse model for embryonal ethanol exposure
... measure methylation of DMRs within the Igf2/H19 ...dinucleotide methylation based on MALDI TOF mass spectrometry, which is an ac- curate, sensitive and high-throughput method for quantitative ... See full document
10
Prediction of disease-related genes based on weighted tissue-specific networks by using DNA methylation
... The primary purpose of this study is to use WTSN to pre- dict disease-related genes. We proposed a PageRank-based method to identify disease-related genes from WTSN. Firstly, TSN was constructed by combining PIN ... See full document
8
Erratum to: DNA methylation age of human tissues and cell types
... aging based on DNA methylation (DNAm) levels ...my analysis of the cancer data, but not of the non-cancer tissue ...the age esti- ...cancerous tissue or cancer cell lines ... See full document
5
DNA methylation age is not affected in psoriatic skin tissue
... the methylation of 353 CpGs, which were ob- tained through an elastic-net regression, to estimate ...“ DNA methylation age calcu- lator ” ...DNAm age of Ps and non-Ps skin ...include ... See full document
7
Multi tissue DNA methylation age predictor in mouse
... Babraham Institute C57BL/6 J/Babr Ageing Mouse Colony Mice were bred and maintained in the Babraham Institute Biological Services Unit (BI BSU) under Specific Opportunistic Pathogen Free (SOPF) conditions. C57BL/6 J mice ... See full document
14
Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model
... suicide prediction model, which de- scribes suicidal behavior as a function of both genotype and methylation at the single nucleotide polymorphism (SNP) rs7208505 in SKA2 which interacts with a state ... See full document
14
Urinary DNA methylation biomarkers for prediction of prostate cancer upgrading and upstaging
... patient age could be associated with upgrading and upstaging, and this observation was partially sup- ported by our ...gene methylation biomarkers, supporting the added value and, thus, clinical ... See full document
10
Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood
... mid-childhood. DNA was extracted using the Qiagen Puregene Kit (Valencia, ...until analysis. DNA was sodium bisulfite con- verted using the EZ DNA Methylation-Gold Kit (Zymo Research, ... See full document
12
Prediction of Plant Height in Arabidopsis thaliana Using DNA Methylation Data
... whole-genome prediction of plant height, as a rea- sonable prediction performance was ...and DNA information for the same ...for prediction using RKHS regression since integrating multiple ... See full document
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