[PDF] Top 20 Multimerization of ICP0, a herpes simplex virus immediate-early protein.
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Multimerization of ICP0, a herpes simplex virus immediate-early protein.
... To determine whether any of the transactivation-deficient IE-0 mutants that we isolated displayed a dominant negative phenotype, Vero cells were cotransfected with equimolar amounts of a[r] ... See full document
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The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27.
... performed to determine the extent of transgene (b-gal) expres- sion as a function of time postinfection with a MOI of 3 PFU per cell. d97-infected Vero and L7 cells stained with X-Gal at 3 and 14 days postinfection are ... See full document
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Herpes Simplex Virus Immediate-Early Protein ICP0 Is Targeted by SIAH-1 for Proteasomal Degradation
... The ICP0 homologs in the genus Simplexvirus in the Alphaherpesvirinae subfamily of her- pesviruses contain the consensus SIAH-1 binding motif PXAXVXPXXR, which is present in many functionally diverse SIAH-1 ...the ... See full document
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Herpes Simplex Virus Immediate-Early Protein ICP22 Triggers Loss of Serine 2-Phosphorylated RNA Polymerase II
... the protein synthesis inhibitor CH ...the protein synthesis inhibitor CH, which leads to the accumulation of high levels of IE ...The protein samples were analyzed by immunoblotting using the ... See full document
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Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon
... cells. Herpes simplex virus type 1 (HSV-1) replication is somewhat reduced in tissue culture in the presence of IFN, presumably due to decreased viral ...inactivate immediate-early (IE) ... See full document
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The Stability of Herpes Simplex Virus 1 ICP0 Early after Infection Is Defined by the RING Finger and the UL13 Protein Kinase
... wild-type ICP0 induces an activity that in turn degrades both itself and the RF mutant, whereas the RF mutant is unable to do ...two ICP0-GFP fusion ...wild-type ICP0 fused to GFP. The chimeric ... See full document
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Regulation of herpes simplex virus poly (A) site usage and the action of immediate-early protein IE63 in the early-late switch.
... essential herpes simplex virus type 1 (HSV-1) immediate-early protein IE63 (ICP27) is pleiotropic in function, promoting the switch from the early to late phase of ... See full document
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Cooperativity among herpes simplex virus type 1 immediate-early regulatory proteins: ICP4 and ICP27 affect the intracellular localization of ICP0.
... To identify the region of the ICPO molecule that responds to ICP27, Vero cells were cotransfected with 1 ,ug of pSH or 1 ,ug of the ICPO nonsense mutant plasmids pn428, pn525, pn680, pn7[r] ... See full document
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Herpes simplex virus induces the marked up regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0
... HSV-1 ICP0 promoter, PCR fragments (-834 to +145 bp) from the HSV-1(F)- infected HEp-2 genome were inserted into the KpnI and XhoI sites of the pGL3 basic luciferase expression ...or ICP0-Luc reporter ... See full document
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Induction of Cellular Stress Overcomes the Requirement of Herpes Simplex Virus Type 1 for Immediate-Early Protein ICP0 and Reactivates Expression from Quiescent Viral Genomes
... of TSA, although only a small proportion of cells produce virus (2, 11, 12, 46, 66, 69, 75, 76). Treatment of cultured ganglia isolated from latently infected mice by heat shock or addition of dexamethasone, but ... See full document
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Recruitment of Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 to the Virus Particle
... before ICP0 translocates into the cytoplasm (21, ...of ICP0 (31). Translocation also requires the IE protein ICP27, and failure of ICP0 to translocate in this ICP27- dependent manner abrogates ... See full document
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Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells.
... Many other tissue-specific genes are also packaged into con- densed, late-replicating chromatin in nonexpressing cells (9, 47). However, this is not universally the case. For example, the human a-globin gene cluster ... See full document
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Overexpression of the herpes simplex virus type 1 immediate-early regulatory protein, ICP27, is responsible for the aberrant localization of ICP0 and mutant forms of ICP4 in ICP4 mutant virus-infected cells.
... expressing ICP0 and mutant forms of ICP4, in which the staining pattern of ICP0 was not changed in the presence of mutant ICP4 ...both ICP0 and ts forms of ICP4 were localized predominantly within ... See full document
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Cells that constitutively express the herpes simplex virus immediate-early protein ICP4 allow efficient activation of viral delayed-early genes in trans.
... 414 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To study the role of herpes simplex virus type 1 immediate-early proteins in the transcriptional activation of herpe[r] ... See full document
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Truncation of the C-Terminal Acidic Transcriptional Activation Domain of Herpes Simplex Virus VP16 Renders Expression of the Immediate-Early Genes Almost Entirely Dependent on ICP0
... ous work, Vero cells infected with n212, in1814 and V422 showed reduced levels of ICP22 RNA relative to the wild-type strains KOS and 17syn⫹, particularly at the lower input MOI (Fig. 3). In contrast, these mutants ... See full document
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Herpes Simplex Virus Type 1 ICP0 Protein Does Not Accumulate in the Nucleus of Primary Neurons in Culture
... genes, ICP0 is a potent promiscuous transactivator of gene expression that has been demonstrated to stimulate expression of HSV IE, E, and L genes, as well as a number of other eukaryotic genes, in ... See full document
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Role of Cyclin D3 in the Biology of Herpes Simplex Virus 1 ICP0
... infected-cell protein 0 (ICP0) binds and stabilizes cyclin D3, that the binding site maps to aspartic acid 199 (D199), and that replacement of D199 with alanine abolishes binding and reduces the capacity of ... See full document
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Differential dependence of herpes simplex virus immediate-early gene expression on de novo-infected cell protein synthesis.
... Addition of the protein synthesis inhibitor anisomycin to cells coincident with infection resulted in maximal rates of transcription and accumulation of functional ICPO mRNA, while 0.5 h[r] ... See full document
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Interaction of herpes simplex virus 1 alpha regulatory protein ICP0 with elongation factor 1delta: ICP0 affects translational machinery.
... The herpes simplex virus 1 (HSV-1)-infected cell protein 0 (ICP0) is a promiscuous transactivator, and by necessity, its functions must be mediated through cellular gene ...with ... See full document
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Herpes simplex virus type 1-specific cytotoxic T lymphocytes recognize immediate-early protein ICP27.
... While all mice strains tested C3H/HeN [H-2k], C57BL/6 [H-2b], and BALB/c [H-2d] demonstrated a vigorous CTL response specific for HSV-1 syngeneic target cells infected with HSV-1 demonst[r] ... See full document
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