[PDF] Top 20 Multiple Effector Functions Mediated by Human Immunodeficiency Virus-Specific CD4+ T-Cell Clones
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Multiple Effector Functions Mediated by Human Immunodeficiency Virus-Specific CD4+ T-Cell Clones
... the T-cell receptor and MHC class II ...HLA-DQ7-restricted clones have been described in a number of other diseases, such as melanoma (38), human papillomavirus type 1 (50), and hepatitis C ... See full document
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A Recombinant Sendai Virus Is Controlled by CD4+ Effector T Cells Responding to a Secreted Human Immunodeficiency Virus Type 1 Envelope Glycoprotein
... Antigen-specific CD4 ⫹ T cells play important but varied roles in experimental models of viral ...case, CD4 ⫹ T-cell help is required to promote high-quality antibody production ... See full document
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Preferential Infection Shortens the Life Span of Human Immunodeficiency Virus-Specific CD4+ T Cells In Vivo
... of CD4 ⫹ T-cell responses to HIV Gag peptides has been ob- served after discontinuation of antiretroviral therapy ...drives CD4 ⫹ T-cell proliferation but is counteracted by ... See full document
9
Herpesvirus Saimiri-Transformed Human CD4+ T-Cell Lines: an Efficient Target Cell System for the Analysis of Human Immunodeficiency Virus-Specific Cytotoxic CD8+T-Lymphocyte Activity
... Cells were analyzed for surface expression of CXCR4 (A and B) and CCR5 (C and D) by flow cytometry (solid lines). Background fluorescence is shown by dotted lines. (E through H) Cells were infected with HIV derived from ... See full document
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Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) Gag- and Gag Peptide-Specific CD4+ T-Cell Clones from an HIV-1-Seronegative Donor following In Vitro Immunization
... by clones 6 and 74 are also contained in peptides presented upon processing of the HIV-1 Gag ...other clones to be activated by recombinant p24 or by vaccinia virus-expressed Gag may indicate that ... See full document
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Establishment and Characterization of Japanese Encephalitis Virus-Specific, Human CD4+ T-Cell Clones: Flavivirus Cross-Reactivity, Protein Recognition, and Cytotoxic Activity
... encephalitis virus (JEV) is a member of the Flavi- viridae and is widely distributed in Japan, China, Taiwan, Ko- rea, Philippines, far eastern Russia, and southeastern Asia (10, 19, ...of ... See full document
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Chronic CD4+ T-Cell Activation and Depletion in Human Immunodeficiency Virus Type 1 Infection: Type I Interferon-Mediated Disruption of T-Cell Dynamics
... in CD4 ⫹ CD25 ⫹ T cells from untreated HIV ⫹ individuals compared to those from HIV ⫺ individuals ...activated CD4 ⫹ T cells during HIV ...in CD4 ⫹ CD25 ⫹ T cells from untreated ... See full document
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Preserved Central Memory and Activated Effector Memory CD4+ T-Cell Subsets in Human Immunodeficiency Virus Controllers: an ANRS EP36 Study
... ⫹ T-cell responses were tested by ICS of cryopreserved ...⫹ CD4 ⫹ T cells produced very small but still detectable amounts of cytokines, while cells stimulated with p24 HIV Gag protein ... See full document
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Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions
... with CD4 ⫹ T cell counts (18–22). Moreover, HIV-1-specific T cells that target highly variable mutational escape epitopes have lower PD-1 levels, while those specific for conserved epitopes ... See full document
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Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T Lymphocytes
... among CD4 downregulation, single-cycle infectivity en- hancement, and replication efficiency in primary T cells, irre- spective of the reason for the Nef activity impairments, we have included these mutants ... See full document
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Determination of antigen specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen specific homeostatic mechanism in HIV associated immunodeficiency
... memory T cells is likely slow, perhaps requiring years to decades to produce measurable changes in the memory ...overall T cell turnover appears to be greatly acceler- ated in HIV infection, and ... See full document
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Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes
... CD8 T cells. To further define potential contribution of HIV-specific CD8 T cells to the observed inhibition, we next established HIV-specific CD8 T-cell lines and clones ... See full document
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Alterations in T-Cell Receptor Vβ Repertoire of CD4 and CD8 T Lymphocytes in Human Immunodeficiency Virus-Infected Children
... these CD4 populations may have specifically responded to ...helper T cells are imperative for CD8-T-cell function, ...depleted CD4 pools no longer possess detectable HIV-specific ... See full document
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Dengue virus-specific, human CD4+ CD8- cytotoxic T-cell clones: multiple patterns of virus cross-reactivity recognized by NS3-specific T-cell clones.
... DISCUSSION In this article we have reported that i Dengue virusspecific, human CD4+ CD8- T-cell clones are heterogeneous with at least six patterns of virus and serotype specificities; i[r] ... See full document
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Bystander Target Cell Lysis and Cytokine Production by Dengue Virus-Specific Human CD4+ Cytotoxic T-Lymphocyte Clones
... lysis mediated by T cells has not been demonstrated in vivo, the ability of the human hep- atocellular cell line HepG2 to serve as a bystander target for the DV-specific ... See full document
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PolyI polyC12U mediated inhibition of loss of alloantigen responsiveness viral replication in human CD4+ T cell clones exposed to human immunodeficiency virus in vitro
... suppression. The mismatched double-stranded RNA blocked HIV-associated particulate reverse transcriptase activity and viral-mediated cytopathic effects. Also, polyI.polyC12U preserved the alloreactivity of ... See full document
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Different Levels of T-Cell Receptor Triggering Induce Distinct Functions in Hepatitis B and Hepatitis C Virus-Specific Human CD4+ T-Cell Clones
... and CD4 down regulation were used as substitute markers for TCR internalization (29, ...of T-cell activation were CD25 and CD54 (intercellular cell ad- hesion molecule 1 [CAM-1]) up ... See full document
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T-Cell Receptor-Mediated Anergy of a Human Immunodeficiency Virus (HIV) gp120-Specific CD4+ Cytotoxic T-Cell Clone, Induced by a Natural HIV Type 1 Variant Peptide
... normally mediated by the nonreceptor PTK Lck, suggests that HXB2 failed to induce the early Lck-mediated phosphorylation and activation of Zap-70 ...downregulate T-cell activation and Zap-70 ... See full document
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Inhibition of Human Immunodeficiency Virus Type 1 gp120 Presentation to CD4 T Cells by Antibodies Specific for the CD4 Binding Domain of gp120
... to T cells by preventing gp120 binding to CD4 on the surfaces of APCs and thereby inhibiting its ...to CD4 on the APC sur- faces. To examine whether gp120 binding to CD4 on APCs is crucial to ... See full document
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Effects of Antiretroviral Drugs on Human Immunodeficiency Virus Type 1-Induced CD4+ T-Cell Death
... blood T cells to apoptosis decreased in HIV-1-infected adults and children treated with highly active antiretroviral therapy (4–6, 11, 26, ...mitogen-stimulated T cells has been reported elsewhere to be ... See full document
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