[PDF] Top 20 Multiple Functions for the Basic Amino Acids of the Human T-Cell Leukemia Virus Type 1 Matrix Protein in Viral Transmission
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Multiple Functions for the Basic Amino Acids of the Human T-Cell Leukemia Virus Type 1 Matrix Protein in Viral Transmission
... that virus particle release is a limiting step in the late events of HTLV-1 replication, because most of the mutated MA proviruses released fewer particles into the cell supernatant than did the wild ... See full document
8
Multimer Formation Is Not Essential for Nuclear Export of Human T-Cell Leukemia Virus Type 1 Rextrans-Activator Protein
... Rev-mediated viral mRNA transport is known to occur independent of any pre-mRNA splicing events (23), it seemed likely that Rex, like Rev, acts primarily at the level of nuclear ...RexM13 protein is ... See full document
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Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1
... Rex protein of human T-cell leukemia virus type 1 acts posttranscriptionally to induce the cytoplasmic expression of incompletely spliced or unspliced mRNAs ... See full document
6
Role of Tax protein in human T cell leukemia virus type I leukemogenicity
... of viral and cellular gene expression by Tax Tax-mediated activation of CREB/ATF-dependent gene expression As noted before, Tax was initially discovered as a transac- tivator of the HTLV-1 gene expression ... See full document
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A novel human T-leukemia virus type 1 cell-to-cell transmission assay permits definition of SU glycoprotein amino acids important for infectivity.
... vitro, cell-free viral infection is ex- tremely difficult to achieve (29, 35, 51), although a low level of successful infection could be obtained for both primary cells (10) and cell lines (6, ... See full document
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The NH2-Terminal Domain of the Human T-Cell Leukemia Virus Type 1 Capsid Protein Is Involved in Particle Formation
... CA protein in particle formation. A comparison of the amino acid sequences of the HTLV-1 CA with that of HIV-1 reveals that they have a number of amino acids in common, some of ... See full document
11
Human T-Cell Leukemia Virus Type 2 Antisense Viral Protein 2 Is Dispensable for In Vitro Immortalization but Functions To Repress Early Virus Replication In Vivo
... Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are closely related but pathogenically distinct human ...HTLV-1 basic leucine zipper ... See full document
10
Inhibition of T-Cell Receptor Signal Transduction and Viral Expression by the Linker for Activation of T Cells-Interacting p12I Protein of Human T-Cell Leukemia/Lymphoma Virus Type 1
... two amino acids revealed an endosomal sorting motif that affects protein ...␥ 1 (E-12), anti-Vav (C-14), and anti-Lyn (H-6) antibodies from Santa Cruz (Santa Cruz, CA); and the anti-CD71 ... See full document
12
The PPPY Motif of Human T-Cell Leukemia Virus Type 1 Gag Protein Is Required Early in the Budding Process
... arrest virus particles at an earlier stage in the budding process than that reported for the mutations of the L domains thus far described in ...the viral protease (14). This prompted us to study the ... See full document
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Human Immunodeficiency Virus Type 1 Genome Activation Induced by Human T-Cell Leukemia Virus Type 1 Tax Protein Is through Cooperation of NF-κB and Tat
... flanking amino acids from 289 to 322 ...two amino acid positions abrogate Tax’s ability to activate NF-kB ...318 amino acids was also con- structed. The wild-type Tax and its ... See full document
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Viral Source-Independent High Susceptibility of Dendritic Cells to Human T-Cell Leukemia Virus Type 1 Infection Compared to That of T Lymphocytes
... uman T-cell leukemia virus type 1 (HTLV-1) infects 5 to 20 million people worldwide (1) and is the etiological agent of both an aggressive CD4 ⫹ ... See full document
11
Increased production of viral proteins by a 3' LTR deleted infectious clone of human T cell leukemia virus type 1
... a human T-cell line. In constructing the HTLV-1 provirus by overlapping PCR, we sometimes isolated an incom- plete provirus with a deletion in the 3' ...the human chromosome 14 DNA ... See full document
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Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication
... DC-to-T-cell transmission, HIV-1 triggers actin polymerization through the use of the formin 2 Rho-GTPase, CDC42, and Env, Nef, and Gag viral proteins ...and viral transfer (64). ... See full document
11
Subnuclear localization of the trans-activating protein of human T-cell leukemia virus type I.
... Other gene products known to be associated with the nuclear matrix include the large T simian virus antigen of 40 8, the viral and cellular myb gene products 6, 45, the viral and cellula[r] ... See full document
7
Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange.
... Plasmid pIW15 represents a Rev trans-activator protein which exerts Rev activity via an activation domain originating from HTLV-I Rex, while the Rex derivative pIW17 acts on the HTLV-I R[r] ... See full document
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Phosphorylation regulates human T cell leukemia virus type 1 Rex function
... the amino-terminal His- tag and S-tag via SmaI and ...Rex-1 amino acid sequence, but severely truncated Tax-1, completely knocking out expression and function ...targeted amino acid ... See full document
11
The role of chromatin in the transcriptional regulation of the human T-cell leukemia virus type 1
... XVll ER estrogen receptor ESAI essential SAS2-related acetyltransferase Exoill Exonuclease III g relative centrifugal force GM-CSF Granulocyte macrophage-colony stimulating factor GR glu[r] ... See full document
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Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.
... on T lymphocytes, with this ligand-receptor pair allowing the attach- ment of lymphocytes to activated ...HTLV-1-infected T lymphocytes is playing a major role in recruiting these cells from the ... See full document
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The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.
... portant functions in the control of viral replication (48, ...the viral genome, ...immunodeficiency virus-rhesus macaque model of AIDS pathogenesis, where it was found to be essential for high ... See full document
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Modulation of T-Cell Responses to a Recall Antigen in Human T-Cell Leukemia Virus Type 1-Infected Individuals
... The hyporesponsiveness to PPD in both HTLV-1-positive and -negative groups appeared to be specific for PPD, since PHA responses were comparable in all groups as previously observed in vivo (9). Analysis of ... See full document
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