[PDF] Top 20 Mutational analysis of the cleavage sequence of the human immunodeficiency virus type 1 envelope glycoprotein precursor gp160.
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Mutational analysis of the cleavage sequence of the human immunodeficiency virus type 1 envelope glycoprotein precursor gp160.
... The gp120 amino acid 516 glutamic acid to glycine mutation, the 517 lysine to isoleucine mutation, and the 518 arginine to lysine mutation have no significant effect on either envelope g[r] ... See full document
6
Mutations in Envelope gp120 Can Impact Proteolytic Processing of the gp160 Precursor and Thereby Affect Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Pseudoviruses
... lane 1, ...for cleavage multiple times, and there was good reproducibility of results (data not ...the gp160 band (data not shown). An analysis of virion-associated Env revealed a surprising ... See full document
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Stabilization of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers by Disulfide Bonds Introduced into the gp41 Glycoprotein Ectodomain
... the human immunodeficiency virus type 1 (HIV-1) gp41 transmembrane envelope glycoprotein have demonstrated that the molecular contacts between alpha helices allow ... See full document
6
Determinants of human immunodeficiency virus type 1 envelope glycoprotein oligomeric structure.
... influenza virus hemagglutinin transmembrane protein HA2 ...of gp160, with approximately 25 to 30% cosedimenting with monomeric ...550-561 sequence may also play a stabilization role for the ... See full document
10
Human immunodeficiency virus type 1 envelope glycoprotein oligomerization requires the gp41 amphipathic alpha-helical/leucine zipper-like sequence.
... mutant glycoprotein, consistent with the coexpressed mutant being recruited into intracellular membrane-anchored or plasma membrane-anchored hetero- ...wild type from vector pS586 and deglycosylation ... See full document
9
Stoichiometry of Envelope Glycoprotein Trimers in the Entry of Human Immunodeficiency Virus Type 1
... proteolytic cleavage of the HA0 precursor into HA1 and HA2 subunits is essential for the entry of all influ- enza ...A virus encodes an HA0 precursor with the sequence ...where ... See full document
16
Reevaluation of the Requirement for TIP47 in Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Incorporation
... Env glycoprotein complex into assembling HIV-1 particles is critical for viral infectivity and ...160-kDa precursor polyprotein (gp160) in the endoplasmic reticulum (ER) and is processed into ... See full document
10
Analysis of the cleavage site of the human immunodeficiency virus type 1 glycoprotein: requirement of precursor cleavage for glycoprotein incorporation.
... Endoproteolytic cleavage of the glycoprotein precursor to the mature SU and TM proteins is an essential step in the maturation of retroviral ...glycoproteins. Cleavage of the precursor ... See full document
8
IN SILICO EPITOPE PREDICTION AND HOMOLOGY MODELING OF ENVELOPE SURFACE GLYCOPROTEIN GP160, PRECURSOR REGION FROM HUMAN IMMUNO DEFICIENCY VIRUS 1
... 3. Homology modeling: The ultimate goal of protein modeling is to predict a structure from its sequence with an accuracy that is comparable to the best results achieved experimentally. In addition, protein ... See full document
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Proteolytic Processing of the Human Immunodeficiency Virus Envelope Glycoprotein Precursor Decreases Conformational Flexibility
... HIV-1 gp160 Env precursor affects multiple Env epitopes in a manner similar to that of glutaraldehyde ...and cleavage were greater than the effects of GA fixation alone (data not ... See full document
6
Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein.
... the cleavage-defective gp140 gly- ...natural gp160 cleavage ...gp120 glycoprotein, since, in contrast to shedding, it occurs efficiently at 4°C, in the absence of the conserved stem of the ... See full document
10
Processing of the envelope glycoprotein gp160 in immunotoxin-resistant cell lines chronically infected with human immunodeficiency virus type 1.
... gp41. Analysis of these cell lines demonstrates the importance of the gp41 transmembrane domain for the correct processing of ...HIV gp160 despite the absence of mutations within the virus ... See full document
10
Antigenicity and Immunogenicity of a Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein
... CON6 gp160 is biologically active and uses CCR5 as its ...a glycoprotein that could pseudotype an env-deficient HIV-1 provirus, CON6 gp160 was cotransfected with HIV-1/SG3 ⌬ env (along ... See full document
10
Mutational Analysis of the C-Terminal Gag Cleavage Sites in Human Immunodeficiency Virus Type 1
... protease cleavage is the difficulty in predicting what sequence substitutions at the protease cleavage site will eliminate protease recognition in the viral ...the cleavage site interrupts ... See full document
8
Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein.
... This highly conserved zipper motif, which consists of a heptad repeat of leucine or isoleucine residues, has been suggested to play a role in HIV-1 env glycoprotein oligomerization.. Thi[r] ... See full document
5
Human immunodeficiency virus type 1 Vpu has a CD4- and an envelope glycoprotein-independent function.
... Because Vpu function was apparently not dependent on HIV-1 Env-gp expression, we wanted to determine whether the reduction in infectious virus produced by the vpu mutant could be due to [r] ... See full document
5
Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus
... cl.4 virus concentrates (1,000⫻) were diluted 1:10 in either sterile TNE buffer or complete medium (RPMI 1640 with 10% fetal bovine serum [FBS] and ...diluted virus preparations were ⬃0.28 mg/ml. ... See full document
11
Peptides Trap the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Fusion Intermediate at Two Sites
... fore, both C34HA and 178HA were tested for binding to the mutant Envs. We found that the proline (Fig. 5A, lane 10), but not the conservative leucine substitution (Fig. 5B, lane 5), greatly reduced the ability of both ... See full document
6
Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase.
... Although the sites of virus-specific cleavages have been determined, the primary amino acid sequences surrounding these sites are hetereogeneous and the determinants that direct the clea[r] ... See full document
10
Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein.
... To compare the ability of different gpl20 mutants to associate with the gp4l transmembrane glycoprotein, the levels of envelope glycoproteins in the lysates and supernatants of the trans[r] ... See full document
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