[PDF] Top 20 Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase.
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Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase.
... Although the sites of virus-specific cleavages have been determined, the primary amino acid sequences surrounding these sites are hetereogeneous and the determinants that direct the clea[r] ... See full document
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Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.
... While it is clear that Vpr causes cell cycle arrest in trans- fected and infected cells (13, 32), it is not clear whether this activity is relevant to HIV-1 replication in monocytes/macro- phages or to AIDS ... See full document
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Mutational Analysis of Residues in the Coiled-Coil Domain of Human Immunodeficiency Virus Type 1 Transmembrane Protein gp41
... its native conforma- tion (prior to fusion-inducing ...wild type; the 570E and 577E mutant Envs showed infectivity at approximately 76 and 18% of wild- type levels, ...wild type (577E, ... See full document
7
Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis.
... This effect did not appear to be due to transactivation of pcDNA-tag-Vpr by a factor encoded by the cotransfected provirus, since increased amounts of tagged Vpr were also present in lys[r] ... See full document
9
Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein.
... This highly conserved zipper motif, which consists of a heptad repeat of leucine or isoleucine residues, has been suggested to play a role in HIV-1 env glycoprotein oligomerization.. Thi[r] ... See full document
5
Linker-scanning mutational analysis of the transcriptional activity of the human immunodeficiency virus type 1 long terminal repeat.
... LTR transcriptional activity obtained by using NXS mutants in Jurkat cells Spl, TATA, LBP-1, UBP-2 a NRE, Negative regulatory element; IL-2, interleukin-2; IL-2Ra, interleukin-2 receptor[r] ... See full document
9
Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminus.
... The Rev protein sequence encoded by pRSV-Rev is that of HIV-1 strain BRU 33; in this sequence, positions 7 to 11 are occupied by a cluster of acidic amino acids that includes one of the [r] ... See full document
7
Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease
... tended substrate interactions, it is unusual that HIV PR is able to catalyze proteolysis of the tetrapeptide ACC substrates, in which only the coumarin binds on the prime ...PR substrate to be P4 to P3⬘ ... See full document
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Structural Analysis of Human Immunodeficiency Virus Type 1 CRF01_AE Protease in Complex with the Substrate p1-p6
... Crystallization and structure determination. The CRF01_AE protease was expressed and purified as previously described (14). The protein was concentrated to 1.8 mg ml ⫺1 using a 10-kDa molecular size limit Amicon ... See full document
5
Mutational Analysis of the Human Immunodeficiency Virus Type 1 Vif Protein
... example, human immunodeficiency virus type 1 (HIV-1) encodes six accessory/regulatory genes in addition to the struc- tural and enzymatic gag, pol, and env genes that are present ... See full document
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Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans
... Our observations for two populations of Africans infected with different HIV-1 subtypes demonstrate functional hetero- geneity for individual alleles within the B58 supertype. We found no appreciable advantage of ... See full document
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The Fitness Cost of Mutations Associated with Human Immunodeficiency Virus Type 1 Drug Resistance Is Modulated by Mutational Interactions
... that mutational interactions can modulate such a fitness ...systematic analysis in the HXB2 background shows that such a fitness cost can vary within a 72-fold range, which predicts that the persistence of ... See full document
5
Mutational Alteration of Human Immunodeficiency Virus Type 1 Vif Allows for Functional Interaction with Nonhuman Primate APOBEC3G
... reporter virus plasmid and a mutant or wild-type pcVif-HA expression ...pseudotyped virus. The results of this analysis showed that a swap that included the R4 sequence (MEEEKR) maintained ... See full document
8
Human Immunodeficiency Virus Type 1 Group M Protease in Cameroon: Genetic Diversity and Protease Inhibitor Mutational Features
... To gain a better insight into the role of distinct Cameroon- ian HIV-1 strains in the contribution of PR amino acid mutations that are linked to PI resistance, we estimated such substitutions in viral strains ... See full document
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Mutational Analysis of Conserved Domains within the Cytoplasmic Tail of gp41 from Human Immunodeficiency Virus Type 1: Effects on Glycoprotein Incorporation and Infectivity
... into virus par- ticles in transfected 293-T ...the virus pellets argues against cellular contamination of these ...phosphorimage analysis and normalized to WT levels for each experiment ... See full document
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Mutational Analysis of the C-Terminal Gag Cleavage Sites in Human Immunodeficiency Virus Type 1
... PCR analysis showed that 2-LTR formation for the SP2-F16S and the p15 mutants was one-half to one-third of the wild-type value and that of the NC cleavage site mutants ... See full document
8
Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA.
... To determine whether sequences that we had previously demonstrated to be important for binding of HIV-1 RNA to the HIV-1 Gag polyprotein in vitro 9, 35 were necessary for packaging of RN[r] ... See full document
10
Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41.
... These results indicated that the expression of the envelope precursor, gpl60, and its subsequent cleavage to gpl20 were not 1799 Downloaded from http://jvi.asm.org/ on November 10, 2019 [r] ... See full document
5
Mutational analysis of the human immunodeficiency virus type 1 env gene product proteolytic cleavage site.
... The aim of this study has been to further analyze the cleavage site at the level of the individual amino acid and assess the importance of site 2 in protease activity by mutating the bas[r] ... See full document
8
Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein.
... pHIV-1CATori is a pUC19-based plasmid containing the SV40 origin of replication HindIllSphI; SV40 nucleotides 5171 to 128 and the XhoI-BamHI fragment encoding the HIV-1 LTR chloramphenic[r] ... See full document
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