[PDF] Top 20 Neuronal degeneration and mitochondrial dysfunction
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Neuronal degeneration and mitochondrial dysfunction
... on neuronal mitochondrial ...similar mitochondrial defects (35). Despite evidence in support of mitochondrial involve- ment in the pathogenesis of HD, the mechanism by which mutated huntingtin ... See full document
11
Chronic exposure to imidacloprid increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris)
... H-imidacloprid. To exclude external contamination of the head and proboscis, we excised the brains for analysis and determined the concentration on the basis of the av- erage size of a bumblebee brain (1.16 ml) (18). We ... See full document
8
IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease
... stress, mitochondrial dysfunction, and neuropathology and delayed lethality in a mouse model of ...increased neuronal Irs2 signaling is not a desirable goal in the intact mammal battling ... See full document
13
Neuroprotective Potential of Genistein in Mitochondrial Dysfunction Mediated Apoptosis in Diabetic Neuronal Complications
... of mitochondrial ROS production as well as its sensitivity for apoptotic pathways is the key role of mitochondrial non protein ...thiols. Mitochondrial non protein thiols keep the thiol groups of its ... See full document
9
Mitochondrial dysfunction in the pathogenesis of neurodegeneration
... in mitochondrial proteins have been found linked to ...of mitochondrial inner membrane carrier proteins has been associated with dystonia (Koehler et al ...progressive degeneration of the basal ... See full document
307
The Physiological and Pathophysiological Role of Epinephrine and Nor-Epinephrine in Alzheimer’s Disease- A Short Communication
... LC degeneration in the pathogenesis of AD has been studied by many scientific groups since the 1960s (Forno 1966; Iversen et ...LC neuronal cells, reducing to as low as 70% in the rostral nuclei leading to ... See full document
11
Mitochondrial dysfunction in Parkinson’s disease
... neuron degeneration 2) mice which harbor protease-deficient OMI S276C mutants, and OMI -knockout mice present motor abnormalities simi- lar to PD, with the progressive neurodegeneration in some brain regions, ... See full document
8
Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain
... substantial mitochondrial dysfunction in human peripheral tissues, especially fibroblasts and blood cells (primarily platelets and lymphocytes) indicate a relation be- tween peripheral and cerebral ... See full document
10
Current concepts of neurodegenerative mechanisms in Alzheimer's disease
... [5]. Mitochondrial associated amyloid precursor protein (APP) forms a complex with the translocase of the outer mitochondrial membrane 40 (TOM40) import channel and the translocase of the inner ... See full document
13
TigarB Causes Mitochondrial Dysfunction and Neuronal Loss in PINK1 Deficiency
... for mitochondrial respiration via TIGAR- mediated inhibition of glycolysis may contribute to this relative substrate deficiency in the absence of PINK func- ...the mitochondrial enlargement identified in ... See full document
12
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease
... cortical neuronal cells for studying disease mechanisms in human ...normal, mitochondrial function was affected; displaying activated NADH-related and inhibited FADH-related respiration, resulting in ... See full document
22
Early Mechanisms of Retinal Degeneration in the harlequin Mouse
... human mitochondrial dysfunction and parainflammation leading to subsequent cerebellar and retinal ...retinal degeneration can be tracked in vivo and is associated with AIF ...retinal ... See full document
187
FREE RADICALS, EPILEPSY AND ANTI-OXIDANT: AN OVERVIEW
... and mitochondrial dysfunction occur as a consequence of prolonged epileptic seizure and may contribute to seizure-induced brain ...and mitochondrial dysfunction are epileptogenic, ...of ... See full document
8
Sirt6 Suppresses High Glucose-Induced Mitochondrial Dysfunction and Apoptosis in Podocytes through AMPK Activation
... [37]. Mitochondrial swelling is a pivotal step for the occurrence of apoptosis as the inner membrane is disrupted and mitochondrial proapoptotic factors are released ...decreased mitochondrial ... See full document
13
A role for taurine in mitochondrial function
... The acyl-CoA dehydrogenases (ACADs) control the beta-oxidation of fatty acids in animal cells and are important mitochondrial enzymes involved in fatty acid degradation. These enzymes exhibit a comparatively low ... See full document
8
The role of mitochondria in aging
... of mitochondrial mutations certainly increase with age ...of mitochondrial genomes, ranging from hundreds to thousands of copies per cell, makes the mere presence of a detected mutation more difficult to ... See full document
10
The Identification of Novel Mechanisms in Neuronal Development and Degeneration
... The dendritic tree is a key determinant of how neuronal information is processed. In the motor system, the dendritic tree of spinal cord neurons undergoes dramatic remodeling in an activity-dependent manner during ... See full document
211
Non invasive monitoring of mitochondrial oxygenation and respiration in critical illness using a novel technique
... surprising and somewhat controversial. Unfortunately, a noninvasive gold standard for measuring (intra)cutaneous oxygen tension is lacking. Although the PpIX-TSLT is quantitative and calibrated, the interpretation of the ... See full document
9
<p>Bridging the Gap Between Physical Health and Autism Spectrum Disorder</p>
... Atypical mitochondrial energy metabolism - elevated blood, urine and cerebrospinal fl uid levels of pyruvate, lactate and alanine alongside serum car- nitine insuf fi ciency - have been reported in cases of ... See full document
14
The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
... to mitochondrial dysfunction has been detected in the post-mortem brains of schi- zophrenia patients via the use of NMR spectroscopy ...of mitochondrial dysfunction and a shift to energy ... See full document
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