[PDF] Top 20 Non-coding RNAs: a key to future personalized molecular therapy?
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Non-coding RNAs: a key to future personalized molecular therapy?
... functions in cancer. Transcription from miRNA genes is under the regulation of transcription factors (TF) that respond to multiple signals and can also be epigenetically controlled. miRNA genes are transcribed by RNA ... See full document
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Non coding RNAs have Key Roles in Cell Regulation
... protein coding genes of significance, observed “day will come when much of population genetics will have to be re-written in terms of the interaction between regulator and structural ...as molecular biology ... See full document
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CncRNAs : RNAs with both coding and non coding roles in development
... as key regulators of distinct developmental processes in animals and ...of non- coding RNAs are evolutionarily conserved and expressed in early embryos, suggesting that they might be involved ... See full document
9
Non-coding RNAs in cardiac regeneration
... at embryonic day 13.5, thinner ventricular walls and ultimately heart failure results due to decreased cardiomyocyte proliferation by suppressing Hand2 [49]. Deletion of miR-1 (miR-1-2) leads to numerous defects in ... See full document
10
Microvesicles in Gliomas and Medulloblastomas: An Overview
... several key molecules that contribute to tumor development and progression, similar to mRNAs, microRNAs and other non-coding RNAs, DNA and even small proteins, MVs can be considered as a ... See full document
10
sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data
... regulatory RNAs, with lengths ranging from 20 to 30 nt, guide Argonaute family proteins to RNA targets and regulate expression of di- verse ...sequences. Non-coding RNAs are the subject of ... See full document
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Long non-coding RNAs in esophageal cancer: molecular mechanisms, functions, and potential applications
... The following three major pathways lead to cell death: apoptosis, autophagy, and necrosis [124]. Currently, few lncRNAs are known to be associated with the latter two pathways of cell death in EC, but several lncRNAs are ... See full document
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Small RNAs in early mammalian development: from gametes to gastrulation
... a key role in this balance by coordinating the expression of selected genes at specific times and ...for future differentiation into the three germ ...small non-coding RNAs. These ... See full document
9
Non coding RNAs and retroviruses
... numerous non-coding RNAs (ncRNA), which act as key regulators in essential cellular processes such as antiviral ...long non-coding RNAs (lncRNAs) are involved in the late ... See full document
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Molecular mechanisms of long non-coding RNAs in anaplastic thyroid cancer: a systematic review
... the key pluripotency genes including OCT4, SOX2, and Nanog [30, 87, ...The molecular mechanism that causes dif- ferences in the expression of these lncRNAs in ATC with PTC still remains ... See full document
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Epigenetic modifications in essential hypertension
... Non-coding RNAs (ncRNA) are implicated in several epigenetic processes, notably small RNAs that can influence histone modifications and cytosine methylation which are connected with gene ... See full document
14
Beyond the proteome: non coding regulatory RNAs
... of non-coding RNA genes is essential for maintain- ing the imprinted status of neighboring ...a non-protein-coding RNA) contains an imprinting control region that is differen- tially ... See full document
8
Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney
... Alpinia oxyphylla (A. oxyphylla) is regarded as a pre- cious drug that is widely distributed in South China. Its fruits are used in Traditional Chinese Medicine for the treatment of intestinal disorders, diarrhea, ... See full document
9
Ribosome profiling reveals resemblance between long non coding RNAs and 5′ leaders of coding RNAs
... of coding transcripts are widely associated with ribosomes, showing relatively high densities of RPFs at locations often corresponding, but not limited, to ... See full document
7
Androgen responsive intronic non-coding RNAs
... Previous reports have shown that a large number of tran- scription-factor binding sites (TFBSs) for well-character- ized transcription factors such as Sp1, c-Myc, p53 and Creb lie upstream to transcriptionally active ... See full document
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Long non-coding RNAs in ovarian cancer
... It has been shown that diverse RNA molecules which harboring miRNA response elements (MREs) can act as competing endogenous RNAs (ceRNAs) [78]. CeRNA crosstalk represents a novel cluster of miRNA regula- tory ... See full document
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cncRNAs : Bi functional RNAs with protein coding and non coding functions
... Fig. 2. Regulatory functions of coding mRNAs. (A) Base pairing leads to RNA degradation/translational regulation. Glucose phosphate stress (G-6-P) leads to activation of transcription of a cncRNA, SgrS. The 5 ... See full document
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RNA: a possible contributor to the 'missing heritability’
... The molecular mechanisms involved are not well-defined, however all the aforementioned examples (many others exist) provide evidence that RNAs are implicated in several important processes, such as trans- ... See full document
7
Long non-coding RNAs in the regulation of myeloid cells
... As is known, macrophages mediate the accelerated in- flammation associated with diabetes complications. Nevertheless, the specific molecular mechanisms are still unknown. In a study by Reddy et al, RNA sequencing ... See full document
12
Long non-coding RNAs in normal and malignant hematopoiesis
... by non-coding RNA (ncRNA) and therefore not translated into canonical functional ...interfering RNAs, microRNAs (miRNAs), PIWI-associated RNAs, small nucleolar RNA, and long ncRNAs (lncRNAs), ... See full document
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