[PDF] Top 20 A novel assay for analysis of the regulation of the function of human osteoclasts
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A novel assay for analysis of the regulation of the function of human osteoclasts
... a novel assay that minimizes the confounding effects of agents on differentiation by meas- uring resorption over a shorter period; and that minimizes inter-culture variability by using each culture as its ... See full document
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Human primary osteoclasts: in vitro generation and applications as pharmacological and clinical assay
... Abstract Osteoclasts are cells of hematopoietic origin with a unique property of dissolving bone; their inhibition is a principle for treatment of diseases of bone ...of human osteoclasts in vitro ... See full document
12
NOX5 in Human Spermatozoa EXPRESSION, FUNCTION, AND REGULATION
... proton currents stimulated by ionomycin were too small to per- mit further analysis. The evidence of a functional interaction between H V 1 and NOX5 came rather from analyzing the effect of the H V 1 functional ... See full document
13
Molecular regulation of HDL metabolism and function: implications for novel therapies
... molecular regulation of HDL metabolism as well as to identify additional genes contributing to variation of HDL-C levels in ...of human genetic syn- dromes ... See full document
12
Identification of novel pathways of regulation of AHR and HIF-1 function
... HIFs are generally upregulated in a broad range of human cancers. HIF has effects on tumor growth and vascularization, and thus patient survival (Keith B, 2012). However, despite HIF’s well established tumor ... See full document
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Regulation of microRNAs function by circular RNAs in human cancer.
... a novel class of diverse endogenous RNAs that regulate miR expression through harboring ...miR regulation by circRNA occurring at the post-transcriptional ...as novel therapeutic targets for cancer ... See full document
17
Novel Enzyme Linked Minisequence Assay for Genotypic Analysis of Human Immunodeficiency Virus Type 1 Drug Resistance
... the assay, ELMA is an excellent candi- date for drug resistance genotyping to be used in developing countries, where, with the greater availability of generic anti- retroviral treatment, the introduction of a drug ... See full document
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Evaluation of immunosuppressive function of regulatory T cells using a novel in vitro cytotoxicity assay
... of human clinical trials are being conducted to investigate the roles of Tregs in treating various immune-mediated ...incorporation assay, which is a radioactive assay; or CFSE based flow cytometry ... See full document
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Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay
... in human clinical retinal therapies, is their ability to phagocytose human ...a novel assay, whereby fresh human retina explants were co-cultured with HESC-derived RPE cells in an ex ... See full document
14
Endopeptidase Regulation as a Novel Function of the Zur Dependent Zinc Starvation Response
... a novel member of this zinc starvation re- sponse, a cell wall hydrolase that retains function and is conditionally essential for cell growth in low-zinc ... See full document
15
Regulation of human megakaryocytopoiesis An in vito analysis
... an assay system for human peripheral blood megakaryocyte colony-forming unit cells (CFU-M) using an anti-platelet glycoprotein antiserum probe to define megakaryocyte colonies grown in ...and ... See full document
10
Regulation and Modulation of Human DNA Polymerase δ Activity and Function
... 2.5. Does the plasticity of Pol δ subunit composition extend to other subunits besides p12? The demonstration that Pol δ is regulated by modification of its quaternary structure raises the question of whether the other ... See full document
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A novel approach to the analysis of human growth
... The PUN approach Given a set of experimental data, the first thing that one may want to do, in order to extract from it as much information as possible, is to find a suitable fitting function. As a next step it ... See full document
15
A Novel Assay for Viral MicroRNA Function Identifies a Single Nucleotide Polymorphism That Affects Drosha Processing
... indicator assay for miRNA activity that relies on the delivery of indicator constructs by transduction rather than by transfec- ...This assay is based on the previously described self-inac- tivating ... See full document
6
The Multifunctional Protein Daxx: Studies of its Biology and Regulation, and Discovery of a Novel Function
... and Regulation, and Discovery of a Novel Function Abstract Daxx, a multifunctional protein with a diverse set of proposed functions, is ubiquitously expressed and highly conserved through ...the ... See full document
153
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein
... post-mortem human brain tis- sue, while the SDS fraction showed higher amounts of total asyn in humans compared to ...and human brain, respect- ively, when the h-asyn is expressed in the rat brain, this ... See full document
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A novel translational regulation function for the simian virus 40 large-T antigen gene.
... our assay than was the determination of transfec- tion efficiency because the capacities of the large-T mutants to complement the translational defect of sub720 correlate with the steady-state levels of large-T ... See full document
11
A cell function study on calcium regulation of a novel calcium-sensing receptor mutation (p.tyr825phe)
... replaced with complete medium (DMEM, 10% FBS, 1×PS). Before calcium measurement, the cells were incubated for 24 hours after replacing the medium with calcium-free DMEM, then were transfected. At 48-hour ... See full document
7
Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins
... Domain analysis showed that both the RNA binding PAZ domain and the RNA processing PIWI domain in PIWIL1 were indispensable for its function in neuronal ... See full document
12
A novel and Rapid LC–MS/MS assay for the Determination of Mycophenolate and Mycophenolic Acid in Human Plasma
... System suitability and carryover test LC–MS system performance was evaluated through system suitability test. Six consecutive injections of a neat sample containing analytes and internal standards were injected in to the ... See full document
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