[PDF] Top 20 Olaratumab in soft-tissue sarcomas.

... leiomyosarcomas as the largest group. The exact effect of various post-study treatments, including local treatments, is not easy to interpret. Differences in the pace of progression before start of treatment might have ... See full document

... to olaratumab monotherapy after disease progression was reported under the category of ‘other’ post-treatment therapy, despite being permitted in the protocol and, more importantly, despite the experimental nature ... See full document

... advanced soft tissue ...of olaratumab. While pre- clinical data show that olaratumab specifically inhibits PDGFR a -mediated oncogenic signal- ling with attendant anti-tumour effects, a lack ... See full document

... therapy olaratumab, a platelet-derived growth factor receptor alpha (PDGFRα) inhibitor, in combination with doxoru- bicin raised hope for a new first-line therapeutic option for advanced STS patients [4]; however, ... See full document

... of olaratumab has been tested in vitro and in vivo, and inhibition of tumor growth has been observed in cancer cell lines, including glioblastoma and leiomyosar- coma ...advanced soft-tissue ... See full document

... a soft tissue sarcoma can certainly influence the technical ease with which resectability can be accomplished, hence it affects the potential for local ...thigh sarcomas disease-free and overall ... See full document

... in soft- tissue sarcoma, owing to its excellent soft-tissue ...on tissue cellularity, with lower ADC values observed in highly cellular or more aggressive regions within tumor ...in ... See full document

... Up to 40% of patients diagnosed with localized soft- tissue sarcoma (STS) will develop metastatic disease [1]. Once metastases are detected, median survival is ap- proximately 12 months, and treatment is ... See full document

... A multicenter, randomized, controlled, open-label study was conducted in Japan on 73 pretreated TRS patients including 19% synovial sarcoma, 8% mesenchymal chond- rosarcoma, and 8% extraskeletal Ewing’s sarcoma/primitive ... See full document

... About 5%–10% of GISTs have a mutation in PDGFR- α . Because of the ability of olaratumab to internalize and down- modulate PDGFR expression, olaratumab was evaluated in patients with PDGFR- α -mutant GIST. ... See full document

... Ewing’s sarcomas (ESs) and osteosarcomas (OSs) and is now considered an inalienable part of the treatment paradigm of these diseases, the role of adjuvant chemo- therapy in adults with non-RMS, non-ES and non-OS ... See full document

... Trabectedin is an active agent in ASTS, particularly in certain subgroups of the disease such as liposarcomas and leiomyo- sarcomas. The optimal schedule for administration as a single agent in advanced disease ... See full document

... alveolar soft part sarcoma; CAR, chimeric antigen receptor; CRs, complete remissions; FDA, Food and Drug Administration; GIST, gastrointestinal stromal tumor; IGF-1R, insulin-like growth factor-1 receptor; LMS, ... See full document

... Aurora kinases have become an attractive target in cancer therapy due to their deregulated expression in human tumors. Liposarcoma, a type of soft tissue sarcoma in adults, account for approximately 20% of ... See full document

... a soft-tissue sarcoma of the trunk or the extremities, the administra- tion of radiotherapy treatment prior to surgery and the absence of metastases at ...of soft-tissue sarcoma who had ... See full document

... metastatic soft tissue sarcomas in adults: a study of the european organization for research and treatment of cancer soft tis- sue and bone sarcoma ... See full document

... extremity sarcomas, however, there is still some limit of limb-salvage for such as huge pelvic tumors considering frequent postoperative infection and postoperative limb function, thus for such ... See full document

... 233. Nielsen T, Hsu FD, O’Connell J, et al. Tissue microarray validation of epi- dermal growth factor receptor and SALL2 in synovial sarcoma with com- parison to tumors of similar histology. Am J Pathol. ... See full document

... 16. Guillou L, Coindre JM, Bonichon F, Nguyen BB, Terrier P, Collin F, Vilain MO, Mandard AM, Le Doussal V, Leroux A, Jacquemier J, Duplay H, Sastre-Garau X, Costa J: Comparative study of the National Cancer Institute ... See full document

... Abstract: Sarcomas are a heterogeneous group of tumors that are traditionally classified according to the morphology and type of tissue that they resemble, such as rhabdomyosarcoma, which resembles skeletal ... See full document